TY - JOUR
T1 - Common gamma chain cytokines: dissidence in the details
AU - Alves, Nuno L.
AU - Arosa, Fernando A.
AU - van Lier, René A. W.
PY - 2007
Y1 - 2007
N2 - Cytokines of the common cytokine-receptor gamma-chain (gamma(c)) family are essential for the development and maintenance of lymphocytes. Herein, we will focus on the roles of interleukin-2 (IL-2), IL-7, IL-15 and IL-21, in the orchestration of CD8 T cell responses. Among these cytokines, IL-7 has emerged as a master regulator of survival of immature and mature T lymphocytes, while IL-2, IL-15 and IL-21 appear to have specific functions in T cell homeostasis and differentiation. Hence, the gamma(c) has evolved as an elegant anchor through which related cytokines regulate distinct biological responses in T cells
AB - Cytokines of the common cytokine-receptor gamma-chain (gamma(c)) family are essential for the development and maintenance of lymphocytes. Herein, we will focus on the roles of interleukin-2 (IL-2), IL-7, IL-15 and IL-21, in the orchestration of CD8 T cell responses. Among these cytokines, IL-7 has emerged as a master regulator of survival of immature and mature T lymphocytes, while IL-2, IL-15 and IL-21 appear to have specific functions in T cell homeostasis and differentiation. Hence, the gamma(c) has evolved as an elegant anchor through which related cytokines regulate distinct biological responses in T cells
U2 - https://doi.org/10.1016/j.imlet.2006.11.006
DO - https://doi.org/10.1016/j.imlet.2006.11.006
M3 - Review article
C2 - 17194484
SN - 0165-2478
VL - 108
SP - 113
EP - 120
JO - Immunology letters
JF - Immunology letters
IS - 2
ER -