TY - JOUR
T1 - Confirmatory factor analysis including MRI-derived adipose tissues quantification improves associations of metabolic dysregulation to diastolic dysfunction
AU - Klarenberg, Hugo
AU - Dekkers, Ilona A.
AU - Peeters, Carel F. W.
AU - de Mutsert, R.
AU - Jukema, J. Wouter
AU - Rosendaal, Frits R.
AU - Leiner, Tim
AU - Gosselink, Mark
AU - Froeling, Martijn
AU - Strijkers, Gustav J.
AU - Boekholdt, S. Matthijs
AU - Lamb, Hildo J.
N1 - Funding Information: The NEO study is supported by the participating departments, the Division and the Board of Directors of the Leiden University Medical Centre , and by the Leiden University , Research Profile Area ‘Vascular and Regenerative Medicine’. “Coagulation factor analyses were funded by ‘Stichting De Merel’. Stichting De Merel had no role in the study design, data collection and analysis, decision to publish, or preparation, review, or approval of the manuscript.” Publisher Copyright: © 2022 Elsevier Inc.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Aims: To quantify metabolic impairment via a one-factor approach with confirmatory factor analysis (CFA) including MRI-derived visceral and subcutaneous adipose tissues and to associate it with diastolic dysfunction. Methods: In this cross-sectional analysis, 916 participants (53% female, mean age (SD): 56 (6)) underwent abdominal and cardiovascular MRI. With CFA a metabolic-load factor of metabolic-syndrome variables and visceral and subcutaneous adipose tissues was constructed. A piecewise structural equation model approach with adjustment for confounding factors was used to determine associations with left-ventricular diastolic function, cardiac morphology and hemodynamics. Results: Model fitting excluding blood pressure and waist circumference but including visceral and subcutaneous adipose tissues, fasting glucose, HDL-c and triglycerides was used to construct the metabolic-load factor. Evaluating measurement invariance demonstrated sex-specificity. Change in mitral early/late peak filling rate ratio was −0.12 for both males [−0.20; −0.05, p > 0.05] and females [−0.17; −0.07, p > 0.001] per SD of metabolic-load factor. Change in deceleration time of mitral early filling was −11.83 ms in females [−17.38; −6.27] per SD of metabolic-load factor. Conclusion: A single latent metabolic-load factor via CFA including MRI-derived adipose tissues increased sensitivity for metabolic impairment obsoleting waist circumference and is associated with a decreased left-ventricular diastolic function, more apparent in females than in males.
AB - Aims: To quantify metabolic impairment via a one-factor approach with confirmatory factor analysis (CFA) including MRI-derived visceral and subcutaneous adipose tissues and to associate it with diastolic dysfunction. Methods: In this cross-sectional analysis, 916 participants (53% female, mean age (SD): 56 (6)) underwent abdominal and cardiovascular MRI. With CFA a metabolic-load factor of metabolic-syndrome variables and visceral and subcutaneous adipose tissues was constructed. A piecewise structural equation model approach with adjustment for confounding factors was used to determine associations with left-ventricular diastolic function, cardiac morphology and hemodynamics. Results: Model fitting excluding blood pressure and waist circumference but including visceral and subcutaneous adipose tissues, fasting glucose, HDL-c and triglycerides was used to construct the metabolic-load factor. Evaluating measurement invariance demonstrated sex-specificity. Change in mitral early/late peak filling rate ratio was −0.12 for both males [−0.20; −0.05, p > 0.05] and females [−0.17; −0.07, p > 0.001] per SD of metabolic-load factor. Change in deceleration time of mitral early filling was −11.83 ms in females [−17.38; −6.27] per SD of metabolic-load factor. Conclusion: A single latent metabolic-load factor via CFA including MRI-derived adipose tissues increased sensitivity for metabolic impairment obsoleting waist circumference and is associated with a decreased left-ventricular diastolic function, more apparent in females than in males.
KW - Confirmatory factor analysis
KW - Diastolic dysfunction
KW - Epidemiology
KW - Magnetic resonance imaging
KW - Metabolic syndrome
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85130297156&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jdiacomp.2022.108202
DO - https://doi.org/10.1016/j.jdiacomp.2022.108202
M3 - Comment/Letter to the editor
C2 - 35491309
SN - 1056-8727
VL - 36
JO - Journal of diabetes and its complications
JF - Journal of diabetes and its complications
IS - 6
M1 - 108202
ER -