TY - JOUR
T1 - Contribution of Coagulopathy on the Risk of Bleeding after Central Venous Catheter Placement in Critically Ill Thrombocytopenic Patients
AU - van Baarle, Floor L F
AU - Tisheh, Arezoe
AU - Jhingoeriesingh, Shanisa S
AU - Vlaar, Alexander P J
AU - Biemond, Bart J
N1 - Funding Information: Supported, in part, by Zorgonderzoek Medische Wetenschappen (part of the Nederlandse Organisatie voor Wetenschappelijk Onderzoek; the Dutch Organization for Scientific Research), Den Haag, The Netherlands, project number 843002625. Publisher Copyright: © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.
PY - 2022/1/21
Y1 - 2022/1/21
N2 - UNLABELLED: Critically ill patients often undergo central venous catheter placement during thrombocytopenia and/or coagulopathy. It is unclear whether severe coagulopathy increases the risk of postprocedural bleeding in critically ill patients with severe thrombocytopenia.DESIGN: Single-center retrospective cohort study.SETTING: Academic mixed ICU in Amsterdam, the Netherlands.PATIENTS: Consecutive severely thrombocytopenic (platelet count ≤ 50 × 109/L) patients who underwent central venous catheter placement between February 2016 and February 2020.INTERVENTIONS: Central venous catheter placement in patients with both severe thrombocytopenia and severe coagulopathy (international normalized ratio > 1.5 and/or activated partial thromboplastin time > 45 s) versus patients with severe thrombocytopenia and normal or mildly prolonged international normalized ratio and activated partial thromboplastin time.MEASUREMENTS AND MAIN RESULTS: We included 289 central venous catheter placements in 175 patients, 112 in patients with and 172 in patients without severe coagulopathy. Median (interquartile range) platelet count was 27 (16-38) and equal for both groups. There were 44 bleeding episodes at the central venous catheter insertion site (15.5%), of which four (1.4%) were grade 2 and two (0.7%) were grade 3. There were 19 bleeding episodes (17.0%) versus 25 bleeding episodes (14.5%) in the coagulopathy and noncoagulopathy groups, of which one and five were of grade 2 or higher, respectively. After correction for confounders, coagulopathy had no effect on bleeding: odds ratio (95% CI) 0.96 (0.24-3.88). Before central venous catheter placement, 116 (40.8%) patients received platelet transfusion. Bleeding at the central venous catheter insertion site occurred in 19 of 116 patients (16.4%) and 25 of 168 patients (14.9%) who did and did not receive platelet transfusion. After correction for confounders, platelet transfusion had no effect on bleeding: odds ratio (95% CI) 0.73 (0.18-2.83).CONCLUSIONS: Coagulopathy was not associated with an increased bleeding risk in severely thrombocytopenic ICU patients undergoing ultrasound guided central venous catheter placement. Prophylactic platelet transfusion in patients with severe thrombocytopenia was not associated with a reduced risk of bleeding.
AB - UNLABELLED: Critically ill patients often undergo central venous catheter placement during thrombocytopenia and/or coagulopathy. It is unclear whether severe coagulopathy increases the risk of postprocedural bleeding in critically ill patients with severe thrombocytopenia.DESIGN: Single-center retrospective cohort study.SETTING: Academic mixed ICU in Amsterdam, the Netherlands.PATIENTS: Consecutive severely thrombocytopenic (platelet count ≤ 50 × 109/L) patients who underwent central venous catheter placement between February 2016 and February 2020.INTERVENTIONS: Central venous catheter placement in patients with both severe thrombocytopenia and severe coagulopathy (international normalized ratio > 1.5 and/or activated partial thromboplastin time > 45 s) versus patients with severe thrombocytopenia and normal or mildly prolonged international normalized ratio and activated partial thromboplastin time.MEASUREMENTS AND MAIN RESULTS: We included 289 central venous catheter placements in 175 patients, 112 in patients with and 172 in patients without severe coagulopathy. Median (interquartile range) platelet count was 27 (16-38) and equal for both groups. There were 44 bleeding episodes at the central venous catheter insertion site (15.5%), of which four (1.4%) were grade 2 and two (0.7%) were grade 3. There were 19 bleeding episodes (17.0%) versus 25 bleeding episodes (14.5%) in the coagulopathy and noncoagulopathy groups, of which one and five were of grade 2 or higher, respectively. After correction for confounders, coagulopathy had no effect on bleeding: odds ratio (95% CI) 0.96 (0.24-3.88). Before central venous catheter placement, 116 (40.8%) patients received platelet transfusion. Bleeding at the central venous catheter insertion site occurred in 19 of 116 patients (16.4%) and 25 of 168 patients (14.9%) who did and did not receive platelet transfusion. After correction for confounders, platelet transfusion had no effect on bleeding: odds ratio (95% CI) 0.73 (0.18-2.83).CONCLUSIONS: Coagulopathy was not associated with an increased bleeding risk in severely thrombocytopenic ICU patients undergoing ultrasound guided central venous catheter placement. Prophylactic platelet transfusion in patients with severe thrombocytopenia was not associated with a reduced risk of bleeding.
KW - central venous catheter
KW - coagulopathy
KW - critical illness
KW - hemorrhage
KW - platelet transfusion
KW - thrombocytopenia
UR - http://www.scopus.com/inward/record.url?scp=85138416620&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/CCE.0000000000000621
DO - https://doi.org/10.1097/CCE.0000000000000621
M3 - Article
C2 - 35083436
SN - 2639-8028
VL - 4
SP - E0621
JO - Critical Care Explorations
JF - Critical Care Explorations
IS - 1
ER -