TY - JOUR
T1 - Cortical and subcortical changes in resting-state neuronal activity and connectivity in early symptomatic ALS and advanced frontotemporal dementia
AU - Govaarts, Rosanne
AU - Beeldman, Emma
AU - Fraschini, Matteo
AU - Griffa, Alessandra
AU - Engels, Marjolein M. A.
AU - van Es, Michael A.
AU - Veldink, Jan H.
AU - van den Berg, Leonard H.
AU - van der Kooi, Anneke J.
AU - Pijnenburg, Yolande A. L.
AU - de Visser, Marianne
AU - Stam, Cornelis J.
AU - Raaphorst, Joost
AU - Hillebrand, Arjan
N1 - Funding Information: The authors would like to acknowledge all patients and their caregivers for participating. We would also like to thank Nico Akemann, Karin Plugge, Marieke Alting Siberg and Marlous van den Hoek for the MEG acquisitions, and Ndedi Sijsma for the MEG acquisitions and visual epoch inspection. Several authors of this publication are members of the Netherlands Neuromuscular Center (NL-NMD) and the European Reference Network for rare neuromuscular diseases ERN-EURO-NMD. This study was funded by the ALS Foundation Netherlands project number 2013-19 and supported by the Dutch Research Council (NWO) project number 023.012.055. Funding Information: This study was funded by the ALS Foundation Netherlands project number 2013-19 and supported by the Dutch Research Council (NWO) project number 023.012.055 . Publisher Copyright: © 2022 The Author(s)
PY - 2022/1/1
Y1 - 2022/1/1
N2 - The objective of this study was to examine if patterns of resting-state brain activity and functional connectivity in cortical and subcortical regions in patients with early symptomatic amyotrophic lateral sclerosis (ALS) resemble those of behavioural variant frontotemporal dementia (bvFTD). In a cross-sectional design, eyes-closed resting-state magnetoencephalography (MEG) data of 34 ALS patients, 18 bvFTD patients and 18 age- and gender-matched healthy controls (HCs) were projected to source-space using an atlas-based beamformer. Group differences in peak frequency, band-specific oscillatory activity and functional connectivity (corrected amplitude envelope correlation) in 78 cortical regions and 12 subcortical regions were determined. False discovery rate was used to correct for multiple comparisons. BvFTD patients, as compared to ALS and HCs, showed lower relative beta power in parietal, occipital, temporal and nearly all subcortical regions. Compared to HCs, patients with ALS and patients with bvFTD had a higher delta (0.5–4 Hz) and gamma (30–48 Hz) band resting-state functional connectivity in a high number of overlapping regions in the frontal lobe and in limbic and subcortical regions. Higher delta band connectivity was widespread in the bvFTD patients compared to HCs. ALS showed a more widespread higher gamma band functional connectivity compared to bvFTD. In conclusion, MEG in early symptomatic ALS patients shows resting-state functional connectivity changes in frontal, limbic and subcortical regions that overlap considerably with bvFTD. The findings show the potential of MEG to detect brain changes in early symptomatic phases of ALS and contribute to our understanding of the disease spectrum, with ALS and bvFTD at the two extreme ends.
AB - The objective of this study was to examine if patterns of resting-state brain activity and functional connectivity in cortical and subcortical regions in patients with early symptomatic amyotrophic lateral sclerosis (ALS) resemble those of behavioural variant frontotemporal dementia (bvFTD). In a cross-sectional design, eyes-closed resting-state magnetoencephalography (MEG) data of 34 ALS patients, 18 bvFTD patients and 18 age- and gender-matched healthy controls (HCs) were projected to source-space using an atlas-based beamformer. Group differences in peak frequency, band-specific oscillatory activity and functional connectivity (corrected amplitude envelope correlation) in 78 cortical regions and 12 subcortical regions were determined. False discovery rate was used to correct for multiple comparisons. BvFTD patients, as compared to ALS and HCs, showed lower relative beta power in parietal, occipital, temporal and nearly all subcortical regions. Compared to HCs, patients with ALS and patients with bvFTD had a higher delta (0.5–4 Hz) and gamma (30–48 Hz) band resting-state functional connectivity in a high number of overlapping regions in the frontal lobe and in limbic and subcortical regions. Higher delta band connectivity was widespread in the bvFTD patients compared to HCs. ALS showed a more widespread higher gamma band functional connectivity compared to bvFTD. In conclusion, MEG in early symptomatic ALS patients shows resting-state functional connectivity changes in frontal, limbic and subcortical regions that overlap considerably with bvFTD. The findings show the potential of MEG to detect brain changes in early symptomatic phases of ALS and contribute to our understanding of the disease spectrum, with ALS and bvFTD at the two extreme ends.
KW - Amyotrophic lateral sclerosis
KW - Behavioural variant frontotemporal dementia
KW - Functional connectivity
KW - Magnetoencephalography
KW - Oscillatory brain activity
KW - Resting-state
UR - http://www.scopus.com/inward/record.url?scp=85125498817&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.nicl.2022.102965
DO - https://doi.org/10.1016/j.nicl.2022.102965
M3 - Article
C2 - 35217500
SN - 2213-1582
VL - 34
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 102965
ER -