Cost-utility analysis of meaning-centered group psychotherapy for cancer survivors

Nadia van der Spek, Femke Jansen, Karen Holtmaat, Joël Vos, William Breitbart, Cornelia F. van Uden-Kraan, Rob A.E.M. Tollenaar, Pim Cuijpers, Veerle M.H. Coupé, Irma M. Verdonck-de Leeuw

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11 Citations (Scopus)


Background: Meaning-centered group psychotherapy for cancer survivors (MCGP-CS) improves meaning, psychological well-being, and mental adjustment to cancer and reduces psychological distress. This randomized controlled trial was conducted to investigate the cost-utility of MCGP-CS compared with supportive group psychotherapy (SGP) and care-as-usual (CAU). Methods: In total, 170 patients were randomized to MCGP-CS, SGP, or CAU. Intervention costs, direct medical and nonmedical costs, productivity losses, and health-related quality of life were measured until 6 months follow-up, using the TIC-P, PRODISQ, data from the hospital information system, and the EQ-5D. The cost-utility was calculated by comparing mean cumulative costs and quality-adjusted life years (QALYs). Results: Mean total costs ranged from €4492 (MCGP-CS) to €5304 (CAU). Mean QALYs ranged.507 (CAU) to.540 (MCGP-CS). MCGP-CS had a probability of 74% to be both less costly and more effective than CAU, and 49% compared with SGP. Sensitivity analyses showed these findings are robust. If society is willing to pay €0 for one gained QALY, MCGP-CS has a 78% probability of being cost-effective compared with CAU. This increases to 85% and 92% at willingness-to-pay thresholds of €10 000 and €30 000, which are commonly accepted thresholds. Conclusions: MCGP-CS is highly likely a cost-effective intervention, meaning that there is a positive balance between the costs and gains of MCGP-CS, in comparison with SGP and CAU.

Original languageEnglish
Pages (from-to)1772-1779
Number of pages8
Issue number7
Early online date6 Apr 2018
Publication statusPublished - 1 Jul 2018


  • MCGP
  • cancer
  • cost-effectiveness
  • cost-utility analysis
  • existential
  • group psychotherapy
  • meaning
  • meaning-centered psychotherapy
  • oncology
  • psychotherapy

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