Deficiency of protease-activated receptor-1 limits bacterial dissemination during severe Gram-negative sepsis (melioidosis)

Liesbeth M. Kager; W. Joost Wiersinga; Joris J. T. H. Roelofs; Cornelis van 't Veer; Tom van der Poll

doi:https://doi.org/10.1016/j.micinf.2013.11.001

Deficiency of protease-activated receptor-1 limits bacterial dissemination during severe Gram-negative sepsis (melioidosis)

Liesbeth M. Kager, W. Joost Wiersinga, Joris J. T. H. Roelofs, Cornelis van 't Veer, Tom van der Poll

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

Protease-activated receptor-1 (PAR-1) is a G-coupled transmembrane receptor expressed by multiple cell types present in the lungs that can be activated by various proteases generated during acute inflammation. In this study we aimed to investigate the role of PAR-1 during melioidosis, a common cause of (pneumo)sepsis in Southeast Asia in a murine model of intranasal inoculation of the causative pathogen Burkholderia (B.) pseudomallei. Our results show that endogenous PAR-1 facilitates bacterial growth and dissemination during murine melioidosis, which is associated with increased cell influxes. However, these observations have no impact on survival. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved

Original language	English
Pages (from-to)	171-174
Journal	Microbes and infection / Institut Pasteur
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.micinf.2013.11.001
Publication status	Published - 2014

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https://doi.org/10.1016/j.micinf.2013.11.001

Cite this

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title = "Deficiency of protease-activated receptor-1 limits bacterial dissemination during severe Gram-negative sepsis (melioidosis)",

abstract = "Protease-activated receptor-1 (PAR-1) is a G-coupled transmembrane receptor expressed by multiple cell types present in the lungs that can be activated by various proteases generated during acute inflammation. In this study we aimed to investigate the role of PAR-1 during melioidosis, a common cause of (pneumo)sepsis in Southeast Asia in a murine model of intranasal inoculation of the causative pathogen Burkholderia (B.) pseudomallei. Our results show that endogenous PAR-1 facilitates bacterial growth and dissemination during murine melioidosis, which is associated with increased cell influxes. However, these observations have no impact on survival. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved",

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T1 - Deficiency of protease-activated receptor-1 limits bacterial dissemination during severe Gram-negative sepsis (melioidosis)

AU - Kager, Liesbeth M.

AU - Wiersinga, W. Joost

AU - Roelofs, Joris J. T. H.

AU - van 't Veer, Cornelis

AU - van der Poll, Tom

PY - 2014

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AB - Protease-activated receptor-1 (PAR-1) is a G-coupled transmembrane receptor expressed by multiple cell types present in the lungs that can be activated by various proteases generated during acute inflammation. In this study we aimed to investigate the role of PAR-1 during melioidosis, a common cause of (pneumo)sepsis in Southeast Asia in a murine model of intranasal inoculation of the causative pathogen Burkholderia (B.) pseudomallei. Our results show that endogenous PAR-1 facilitates bacterial growth and dissemination during murine melioidosis, which is associated with increased cell influxes. However, these observations have no impact on survival. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved

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