TY - JOUR
T1 - Diagnostic tools for the study of vascular cognitive dysfunction in hypertension and antihypertensive drug research
AU - Semplicini, Andrea
AU - Amodio, Piero
AU - Leonetti, Gastone
AU - Cuspidi, Cesare
AU - Umiltà, Carlo
AU - Schiff, Sami
AU - Scheltens, Philip
AU - Barkhof, Frederik
AU - Emanueli, Costanza
AU - Cagnin, Annachiara
AU - Pizzolato, Gilberto
AU - Macchini, Luisa
AU - Realdi, Anna
AU - Royter, Vladimir
AU - Bornstein, Natan M.
AU - Madeddu, Paolo
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Arterial hypertension is one of the main risk factors for cerebrovascular diseases, and antihypertensive treatment has significantly reduced their associated mortality. However, morbidity has not been reduced to a similar extent and a still increasing number of patients suffers from recurring strokes and from the disabling consequences of cerebrovascular diseases and develops progressive cognitive impairment. It is still debated to what extent antihypertensive treatment may prevent the development of cognitive dysfunction, due to the lack of a focused approach to vascular cognitive impairment, to the lack of a systematic study of the early phases of dementia, and to the use of diagnostic tests that are not sensitive and specific for a slow onset clinical condition, such as dementia. The aim of the present expert consensus report is to enlist the diagnostic tools that are currently available to assess mild cognitive impairment (MCI) and early dementia and that are sensitive and specific enough to be used in observational, longitudinal, and interventional clinical research studies, aiming to investigate the impact of antihypertensive drugs on vascular dementia (VD).
AB - Arterial hypertension is one of the main risk factors for cerebrovascular diseases, and antihypertensive treatment has significantly reduced their associated mortality. However, morbidity has not been reduced to a similar extent and a still increasing number of patients suffers from recurring strokes and from the disabling consequences of cerebrovascular diseases and develops progressive cognitive impairment. It is still debated to what extent antihypertensive treatment may prevent the development of cognitive dysfunction, due to the lack of a focused approach to vascular cognitive impairment, to the lack of a systematic study of the early phases of dementia, and to the use of diagnostic tests that are not sensitive and specific for a slow onset clinical condition, such as dementia. The aim of the present expert consensus report is to enlist the diagnostic tools that are currently available to assess mild cognitive impairment (MCI) and early dementia and that are sensitive and specific enough to be used in observational, longitudinal, and interventional clinical research studies, aiming to investigate the impact of antihypertensive drugs on vascular dementia (VD).
KW - Antihypertensive drug therapy
KW - Arterial hypertension
KW - Clinical trials
KW - Cognitive impairment
KW - Vascular dementia
UR - http://www.scopus.com/inward/record.url?scp=28444487433&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.pharmthera.2005.08.010
DO - https://doi.org/10.1016/j.pharmthera.2005.08.010
M3 - Review article
C2 - 16202453
SN - 0163-7258
VL - 109
SP - 274
EP - 283
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
IS - 1-2
ER -