TY - JOUR
T1 - Diseases of intramembranous lipid transport
AU - Paulusma, Coen C.
AU - Oude Elferink, Ronald P. J.
PY - 2006
Y1 - 2006
N2 - The maintenance of transbilayer distribution of phospholipids is crucial for proper cell function. Intramembrane transport of lipids is mediated by three activities termed floppases, flippases, and scramblases. Members of the ATP-binding cassette transporter family and P-type ATPase superfamily have been implicated in the translocation of lipids. The importance of these activities is exemplified by several severe human inherited disorders that are caused by defects in intramembranous transport of lipids. In order to elucidate the molecular mechanisms that underlie these disorders, the combination of in vivo, biochemical, and structural analyses on intramembrane transporters is crucial
AB - The maintenance of transbilayer distribution of phospholipids is crucial for proper cell function. Intramembrane transport of lipids is mediated by three activities termed floppases, flippases, and scramblases. Members of the ATP-binding cassette transporter family and P-type ATPase superfamily have been implicated in the translocation of lipids. The importance of these activities is exemplified by several severe human inherited disorders that are caused by defects in intramembranous transport of lipids. In order to elucidate the molecular mechanisms that underlie these disorders, the combination of in vivo, biochemical, and structural analyses on intramembrane transporters is crucial
U2 - https://doi.org/10.1016/j.febslet.2006.06.067
DO - https://doi.org/10.1016/j.febslet.2006.06.067
M3 - Review article
C2 - 16828084
SN - 0014-5793
VL - 580
SP - 5500
EP - 5509
JO - FEBS letters
JF - FEBS letters
IS - 23
ER -