Drug transport to the brain: in vitro versus in vivo approaches

A. G. de Boer, H. E. de Vries, E. C.M. de Lange, M. Danhof, J. Kuiper, D. D. Breimer

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This paper summarizes the applicability of in vitro and in vivo methods to assess drug transport to the brain. In vitro methods: culture of confluent monolayers of bovine brain endothelial cells which represent the blood-brain barrier (BBB) and confocal laser scanning microscopy. In vivo methods: BBB-clearance model and microdialysis in rats. Ascertaining selectivity in BBB-transport in disease states is emphasized.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalJournal of controlled release
Issue number1-3
Publication statusPublished - Jan 1994


  • BBB-clearance model
  • Blood-brain barrier
  • Bovine brain endothelial cell
  • Confocal laser scanning microscopy
  • In vitro/in vivo method
  • Microdialysis

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