TY - JOUR
T1 - Early stages in human and mouse T-cell development
AU - Spits, H.
PY - 1994
Y1 - 1994
N2 - One important question in lymphopoiesis is where stem cells commit to T-, B- and natural killer (NK)-cell lineages. Recent findings in human and mouse systems suggest that the thymus is seeded by a yet uncommitted progenitor cell. The earliest murine thymic progenitor cells have the capacity to develop into B, T and NK cells when introduced into the appropriate microenvironment. The mechanisms underlying T-cell commitment are unknown, but cytokines might be involved. The gamma-chain of the interleukin (IL)-2 receptor seems to play a role in development of T and NK cells, but the current data argue against a critical role for IL-2 in T- and NK-cell development. This suggests that the IL-2 receptor gamma-chain is part of a receptor for another cytokine, important for T- and NK-cell development. IL-7 might be involved in regulating T-cell receptor rearrangements and in proliferation of cells within the thymus
AB - One important question in lymphopoiesis is where stem cells commit to T-, B- and natural killer (NK)-cell lineages. Recent findings in human and mouse systems suggest that the thymus is seeded by a yet uncommitted progenitor cell. The earliest murine thymic progenitor cells have the capacity to develop into B, T and NK cells when introduced into the appropriate microenvironment. The mechanisms underlying T-cell commitment are unknown, but cytokines might be involved. The gamma-chain of the interleukin (IL)-2 receptor seems to play a role in development of T and NK cells, but the current data argue against a critical role for IL-2 in T- and NK-cell development. This suggests that the IL-2 receptor gamma-chain is part of a receptor for another cytokine, important for T- and NK-cell development. IL-7 might be involved in regulating T-cell receptor rearrangements and in proliferation of cells within the thymus
U2 - https://doi.org/10.1016/0952-7915(94)90094-9
DO - https://doi.org/10.1016/0952-7915(94)90094-9
M3 - Review article
C2 - 8011206
SN - 0952-7915
VL - 6
SP - 212
EP - 221
JO - Current opinion in immunology
JF - Current opinion in immunology
IS - 2
ER -