TY - JOUR
T1 - Elevated plasma inflammatory mediators in post-polio syndrome: No association with long-term functional decline
AU - Bickerstaffe, A.
AU - Beelen, A.
AU - Lutter, R.
AU - Nollet, F.
PY - 2015
Y1 - 2015
N2 - A key feature of post-polio syndrome (PPS) is progressive loss of muscle strength. In other chronic diseases systemic inflammation has been linked to muscle wasting. In this study plasma TNF-α, IL-6, IL-8, and leptin levels were significantly increased in PPS-patients compared to healthy controls. There was however no association between these raised systemic levels of inflammatory mediators and long-term decline in quadriceps strength or other clinical parameters. In conclusion, there is evidence for systemic inflammation in PPS, yet the relationship with clinical deterioration remains tenuous
AB - A key feature of post-polio syndrome (PPS) is progressive loss of muscle strength. In other chronic diseases systemic inflammation has been linked to muscle wasting. In this study plasma TNF-α, IL-6, IL-8, and leptin levels were significantly increased in PPS-patients compared to healthy controls. There was however no association between these raised systemic levels of inflammatory mediators and long-term decline in quadriceps strength or other clinical parameters. In conclusion, there is evidence for systemic inflammation in PPS, yet the relationship with clinical deterioration remains tenuous
U2 - https://doi.org/10.1016/j.jneuroim.2015.10.019
DO - https://doi.org/10.1016/j.jneuroim.2015.10.019
M3 - Article
C2 - 26616886
SN - 0165-5728
VL - 289
SP - 162
EP - 167
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -