Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes

J.S. ten Kulve; D.J. Veltman; L. van Bloemendaal; F. Barkhof; C.F. Deacon; J.J. Holst; R.J. Konrad; J.H. Sloan; M.L. Drent; M. Diamant; R.G. IJzerman

doi:https://doi.org/10.1007/s00125-015-3754-x

Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes

J.S. ten Kulve, D.J. Veltman, L. van Bloemendaal, F. Barkhof, C.F. Deacon, J.J. Holst, R.J. Konrad, J.H. Sloan, M.L. Drent, M. Diamant, R.G. IJzerman

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Aims/hypothesis: The central nervous system (CNS) is a major player in the regulation of food intake. The gut hormone glucagon-like peptide-1 (GLP-1) has been proposed to have an important role in this regulation by relaying information about nutritional status to the CNS. We hypothesised that endogenous GLP-1 has effects on CNS reward and satiety circuits. Methods: This was a randomised, crossover, placebo-controlled intervention study, performed in a university medical centre in the Netherlands. We included patients with type 2 diabetes and healthy lean control subjects. Individuals were eligible if they were 40–65 years. Inclusion criteria for the healthy lean individuals included a BMI <25 kg/m

Original language	English
Pages (from-to)	2688-2698
Journal	Diabetologia
Volume	58
Issue number	12
DOIs	https://doi.org/10.1007/s00125-015-3754-x
Publication status	Published - 2015

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Cite this

ten Kulve, J. S., Veltman, D. J., van Bloemendaal, L., Barkhof, F., Deacon, C. F., Holst, J. J., Konrad, R. J., Sloan, J. H., Drent, M. L., Diamant, M., & IJzerman, R. G. (2015). Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes. Diabetologia, 58(12), 2688-2698. https://doi.org/10.1007/s00125-015-3754-x

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title = "Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes",

abstract = "Aims/hypothesis: The central nervous system (CNS) is a major player in the regulation of food intake. The gut hormone glucagon-like peptide-1 (GLP-1) has been proposed to have an important role in this regulation by relaying information about nutritional status to the CNS. We hypothesised that endogenous GLP-1 has effects on CNS reward and satiety circuits. Methods: This was a randomised, crossover, placebo-controlled intervention study, performed in a university medical centre in the Netherlands. We included patients with type 2 diabetes and healthy lean control subjects. Individuals were eligible if they were 40–65 years. Inclusion criteria for the healthy lean individuals included a BMI <25 kg/m",

author = "{ten Kulve}, J.S. and D.J. Veltman and {van Bloemendaal}, L. and F. Barkhof and C.F. Deacon and J.J. Holst and R.J. Konrad and J.H. Sloan and M.L. Drent and M. Diamant and R.G. IJzerman",

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ten Kulve, JS, Veltman, DJ , van Bloemendaal, L , Barkhof, F, Deacon, CF, Holst, JJ, Konrad, RJ, Sloan, JH, Drent, ML, Diamant, M & IJzerman, RG 2015, 'Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes', Diabetologia, vol. 58, no. 12, pp. 2688-2698. https://doi.org/10.1007/s00125-015-3754-x

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AU - ten Kulve, J.S.

AU - Veltman, D.J.

AU - van Bloemendaal, L.

AU - Barkhof, F.

AU - Deacon, C.F.

AU - Holst, J.J.

AU - Konrad, R.J.

AU - Sloan, J.H.

AU - Drent, M.L.

AU - Diamant, M.

AU - IJzerman, R.G.

PY - 2015

Y1 - 2015

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