TY - JOUR
T1 - Endoscopic intermuscular dissection for deep submucosal invasive cancer in the rectum
T2 - A new endoscopic approach
AU - Moons, Leon M. G.
AU - Bastiaansen, Barbara A. J.
AU - Richir, Milan C.
AU - Hazen, Wouter L.
AU - Tuynman, Jurriaan
AU - Elias, Sjoerd G.
AU - Schrauwen, Ruud W. M.
AU - Vleggaar, Frank P.
AU - Dekker, Evelien
AU - Bos, Philip
AU - Fariña Sarasqueta, Arantza
AU - Lacle, Miangela
AU - Hompes, Roel
AU - Didden, Paul
N1 - Publisher Copyright: © 2022 Georg Thieme Verlag. All rights reserved.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Background The risk of lymph node metastasis associated with deep submucosal invasion should be balanced against the mortality and morbidity of total mesorectal excision (TME). Dissection through the submucosa hinders radical deep resection, and full-thickness resection may influence the outcome of completion TME. Endoscopic intermuscular dissection (EID) in between the circular and longitudinal part of the muscularis propria could potentially provide an R0 resection while leaving the rectal wall intact. Methods In this prospective cohort study, the data of patients treated with EID for suspected deep submucosal invasive rectal cancer between 2018 and 2020 were analyzed. Study outcomes were the percentages of technical success, R0 resection, curative resection, and adverse events. Results 67 patients (median age 67 years; 73% men) were included. The median lesion size was 25mm (interquartile range 20-33mm). The rates of overall technical success, R0 resection, and curative resection were 96% (95%CI 89%-99%), 81% (95%CI 70%-89%), and 45% (95%CI 33%-57%). Only minor adverse events occurred in eight patients (12%). Conclusion EID for deep invasive T1 rectal cancer appears to be feasible and safe, and the high R0 resection rate creates the potential of rectal preserving therapy in 45% of patients.
AB - Background The risk of lymph node metastasis associated with deep submucosal invasion should be balanced against the mortality and morbidity of total mesorectal excision (TME). Dissection through the submucosa hinders radical deep resection, and full-thickness resection may influence the outcome of completion TME. Endoscopic intermuscular dissection (EID) in between the circular and longitudinal part of the muscularis propria could potentially provide an R0 resection while leaving the rectal wall intact. Methods In this prospective cohort study, the data of patients treated with EID for suspected deep submucosal invasive rectal cancer between 2018 and 2020 were analyzed. Study outcomes were the percentages of technical success, R0 resection, curative resection, and adverse events. Results 67 patients (median age 67 years; 73% men) were included. The median lesion size was 25mm (interquartile range 20-33mm). The rates of overall technical success, R0 resection, and curative resection were 96% (95%CI 89%-99%), 81% (95%CI 70%-89%), and 45% (95%CI 33%-57%). Only minor adverse events occurred in eight patients (12%). Conclusion EID for deep invasive T1 rectal cancer appears to be feasible and safe, and the high R0 resection rate creates the potential of rectal preserving therapy in 45% of patients.
UR - http://www.scopus.com/inward/record.url?scp=85130358447&partnerID=8YFLogxK
U2 - https://doi.org/10.1055/a-1748-8573
DO - https://doi.org/10.1055/a-1748-8573
M3 - Article
C2 - 35073588
SN - 0013-726X
VL - 54
SP - 993
EP - 998
JO - Endoscopy
JF - Endoscopy
IS - 10
ER -