TY - JOUR
T1 - Endoscopic ultrasonography as additional preoperative workup is valuable in half of the patients with a pancreatic body or tail lesion
AU - Janssen, Quisette P.
AU - Gorris, Myrte
AU - van den Broek, Bram L. J.
AU - Besselink, Marc G.
AU - Busch, Olivier R.
AU - van Eijck, Casper H. J.
AU - Groot Koerkamp, Bas
AU - van Hooft, Jeanin E.
AU - van Driel, Lydi M. J. W.
N1 - Funding Information: This study is supported by the Dutch Cancer Society (10955) and by ZonMw (843004108). No funding agency was involved in the design of the study, or the collection, analysis, and interpretation of data. The authors are solely responsible for the content of the study and do not necessarily represent the viewpoint of the Dutch Cancer Society or ZonMw. Funding Information: This study is supported by the Dutch Cancer Society ( 10955 ) and by ZonMw ( 843004108 ). No funding agency was involved in the design of the study, or the collection, analysis, and interpretation of data. The authors are solely responsible for the content of the study and do not necessarily represent the viewpoint of the Dutch Cancer Society or ZonMw. Funding Information: We would like to acknowledge T. Mungroop for the coordination of the prospective patient selection that formed the basis for this study, and the Dutch Cancer Society and ZonMw for their financial support. Publisher Copyright: © 2021 The Author(s)
PY - 2021
Y1 - 2021
N2 - Background: The management of pancreatic body and tail lesions is underexposed. It remains unclear whether endoscopic ultrasonography (EUS) increases the accuracy of the preoperative workup. This study assessed the diagnostic value and safety of EUS in addition to cross-sectional imaging in a surgical cohort of patients with pancreatic body or tail lesions. Methods: A multicenter retrospective cohort study was performed of patients who underwent distal pancreatectomy from 2010 to 2017. The composite primary outcome was the additional value of EUS, defined as: (a) EUS confirmed an uncertain diagnosis on cross-sectional imaging, (b) EUS was correct in case of discrepancy with cross-sectional imaging, or (c) EUS provided tissue diagnosis for neoadjuvant treatment. Furthermore, serious adverse events and needle tract seeding were assessed. Results: In total, 181 patients were included, of whom 123 (68%) underwent EUS besides cross-sectional imaging. Postoperative pathology was heterogeneous: 91 was malignant, 49 premalignant, 41 benign. Most lesions were solid (n = 117). EUS had additional value in 59/123 (48%) patients; 27/50 (54%) of cystic and 32/73 (44%) of solid lesions. No serious adverse event or needle tract seeding following EUS occurred. Conclusion: EUS had additional value besides cross-sectional imaging in half of the patients and showed low associated risks.
AB - Background: The management of pancreatic body and tail lesions is underexposed. It remains unclear whether endoscopic ultrasonography (EUS) increases the accuracy of the preoperative workup. This study assessed the diagnostic value and safety of EUS in addition to cross-sectional imaging in a surgical cohort of patients with pancreatic body or tail lesions. Methods: A multicenter retrospective cohort study was performed of patients who underwent distal pancreatectomy from 2010 to 2017. The composite primary outcome was the additional value of EUS, defined as: (a) EUS confirmed an uncertain diagnosis on cross-sectional imaging, (b) EUS was correct in case of discrepancy with cross-sectional imaging, or (c) EUS provided tissue diagnosis for neoadjuvant treatment. Furthermore, serious adverse events and needle tract seeding were assessed. Results: In total, 181 patients were included, of whom 123 (68%) underwent EUS besides cross-sectional imaging. Postoperative pathology was heterogeneous: 91 was malignant, 49 premalignant, 41 benign. Most lesions were solid (n = 117). EUS had additional value in 59/123 (48%) patients; 27/50 (54%) of cystic and 32/73 (44%) of solid lesions. No serious adverse event or needle tract seeding following EUS occurred. Conclusion: EUS had additional value besides cross-sectional imaging in half of the patients and showed low associated risks.
UR - http://www.scopus.com/inward/record.url?scp=85118663598&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.hpb.2021.10.005
DO - https://doi.org/10.1016/j.hpb.2021.10.005
M3 - Article
C2 - 34732301
SN - 1365-182X
JO - HPB
JF - HPB
ER -