Evidence of innate lymphoid cell redundancy in humans

Frédéric Vély; Vincent Barlogis; Blandine Vallentin; Bénédicte Neven; Christelle Piperoglou; Mikael Ebbo; Thibaut Perchet; Maxime Petit; Nadia Yessaad; Fabien Touzot; Julie Bruneau; Nizar Mahlaoui; Nicolas Zucchini; Catherine Farnarier; Gérard Michel; Despina Moshous; Stéphane Blanche; Arnaud Dujardin; Hergen Spits; Jörg H. W. Distler; Andreas Ramming; Capucine Picard; Rachel Golub; Alain Fischer; Eric Vivier

doi:https://doi.org/10.1038/ni.3553

Evidence of innate lymphoid cell redundancy in humans

Frédéric Vély, Vincent Barlogis, Blandine Vallentin, Bénédicte Neven, Christelle Piperoglou, Mikael Ebbo, Thibaut Perchet, Maxime Petit, Nadia Yessaad, Fabien Touzot, Julie Bruneau, Nizar Mahlaoui, Nicolas Zucchini, Catherine Farnarier, Gérard Michel, Despina Moshous, Stéphane Blanche, Arnaud Dujardin, Hergen Spits, Jörg H. W. DistlerAndreas Ramming, Capucine Picard, Rachel Golub, Alain Fischer, Eric Vivier

Research output: Contribution to journal › Article › Academic › peer-review

247 Citations (Scopus)

Abstract

Innate lymphoid cells (ILCs) have potent immunological functions in experimental conditions in mice, but their contributions to immunity in natural conditions in humans have remained unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in patients with SCID who had mutation of the gene encoding the common γ-chain cytokine receptor subunit IL-2Rγ or the gene encoding the tyrosine kinase JAK3. T cell reconstitution was observed in patients with SCID after hematopoietic stem cell transplantation (HSCT), but the patients still had considerably fewer ILCs in the absence of myeloablation than did healthy control subjects, with the exception of rare cases of reconstitution of the ILC1 subset of ILCs. Notably, the ILC deficiencies observed were not associated with any particular susceptibility to disease, with follow-up extending from 7 years to 39 years after HSCT. We thus report here selective ILC deficiency in humans and show that ILCs might be dispensable in natural conditions, if T cells are present and B cell function is preserved

Original language	English
Pages (from-to)	1291-1299
Journal	Nature immunology
Volume	17
Issue number	11
DOIs	https://doi.org/10.1038/ni.3553
Publication status	Published - 2016

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Vély, F., Barlogis, V., Vallentin, B., Neven, B., Piperoglou, C., Ebbo, M., Perchet, T., Petit, M., Yessaad, N., Touzot, F., Bruneau, J., Mahlaoui, N., Zucchini, N., Farnarier, C., Michel, G., Moshous, D., Blanche, S., Dujardin, A., Spits, H., ... Vivier, E. (2016). Evidence of innate lymphoid cell redundancy in humans. Nature immunology, 17(11), 1291-1299. https://doi.org/10.1038/ni.3553

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title = "Evidence of innate lymphoid cell redundancy in humans",

abstract = "Innate lymphoid cells (ILCs) have potent immunological functions in experimental conditions in mice, but their contributions to immunity in natural conditions in humans have remained unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in patients with SCID who had mutation of the gene encoding the common γ-chain cytokine receptor subunit IL-2Rγ or the gene encoding the tyrosine kinase JAK3. T cell reconstitution was observed in patients with SCID after hematopoietic stem cell transplantation (HSCT), but the patients still had considerably fewer ILCs in the absence of myeloablation than did healthy control subjects, with the exception of rare cases of reconstitution of the ILC1 subset of ILCs. Notably, the ILC deficiencies observed were not associated with any particular susceptibility to disease, with follow-up extending from 7 years to 39 years after HSCT. We thus report here selective ILC deficiency in humans and show that ILCs might be dispensable in natural conditions, if T cells are present and B cell function is preserved",

author = "Fr{\'e}d{\'e}ric V{\'e}ly and Vincent Barlogis and Blandine Vallentin and B{\'e}n{\'e}dicte Neven and Christelle Piperoglou and Mikael Ebbo and Thibaut Perchet and Maxime Petit and Nadia Yessaad and Fabien Touzot and Julie Bruneau and Nizar Mahlaoui and Nicolas Zucchini and Catherine Farnarier and G{\'e}rard Michel and Despina Moshous and St{\'e}phane Blanche and Arnaud Dujardin and Hergen Spits and Distler, {J{\"o}rg H. W.} and Andreas Ramming and Capucine Picard and Rachel Golub and Alain Fischer and Eric Vivier",

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doi = "https://doi.org/10.1038/ni.3553",

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Vély, F, Barlogis, V, Vallentin, B, Neven, B, Piperoglou, C, Ebbo, M, Perchet, T, Petit, M, Yessaad, N, Touzot, F, Bruneau, J, Mahlaoui, N, Zucchini, N, Farnarier, C, Michel, G, Moshous, D, Blanche, S, Dujardin, A, Spits, H, Distler, JHW, Ramming, A, Picard, C, Golub, R, Fischer, A & Vivier, E 2016, 'Evidence of innate lymphoid cell redundancy in humans', Nature immunology, vol. 17, no. 11, pp. 1291-1299. https://doi.org/10.1038/ni.3553

TY - JOUR

T1 - Evidence of innate lymphoid cell redundancy in humans

AU - Vély, Frédéric

AU - Barlogis, Vincent

AU - Vallentin, Blandine

AU - Neven, Bénédicte

AU - Piperoglou, Christelle

AU - Ebbo, Mikael

AU - Perchet, Thibaut

AU - Petit, Maxime

AU - Yessaad, Nadia

AU - Touzot, Fabien

AU - Bruneau, Julie

AU - Mahlaoui, Nizar

AU - Zucchini, Nicolas

AU - Farnarier, Catherine

AU - Michel, Gérard

AU - Moshous, Despina

AU - Blanche, Stéphane

AU - Dujardin, Arnaud

AU - Spits, Hergen

AU - Distler, Jörg H. W.

AU - Ramming, Andreas

AU - Picard, Capucine

AU - Golub, Rachel

AU - Fischer, Alain

AU - Vivier, Eric

PY - 2016

Y1 - 2016

N2 - Innate lymphoid cells (ILCs) have potent immunological functions in experimental conditions in mice, but their contributions to immunity in natural conditions in humans have remained unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in patients with SCID who had mutation of the gene encoding the common γ-chain cytokine receptor subunit IL-2Rγ or the gene encoding the tyrosine kinase JAK3. T cell reconstitution was observed in patients with SCID after hematopoietic stem cell transplantation (HSCT), but the patients still had considerably fewer ILCs in the absence of myeloablation than did healthy control subjects, with the exception of rare cases of reconstitution of the ILC1 subset of ILCs. Notably, the ILC deficiencies observed were not associated with any particular susceptibility to disease, with follow-up extending from 7 years to 39 years after HSCT. We thus report here selective ILC deficiency in humans and show that ILCs might be dispensable in natural conditions, if T cells are present and B cell function is preserved

AB - Innate lymphoid cells (ILCs) have potent immunological functions in experimental conditions in mice, but their contributions to immunity in natural conditions in humans have remained unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in patients with SCID who had mutation of the gene encoding the common γ-chain cytokine receptor subunit IL-2Rγ or the gene encoding the tyrosine kinase JAK3. T cell reconstitution was observed in patients with SCID after hematopoietic stem cell transplantation (HSCT), but the patients still had considerably fewer ILCs in the absence of myeloablation than did healthy control subjects, with the exception of rare cases of reconstitution of the ILC1 subset of ILCs. Notably, the ILC deficiencies observed were not associated with any particular susceptibility to disease, with follow-up extending from 7 years to 39 years after HSCT. We thus report here selective ILC deficiency in humans and show that ILCs might be dispensable in natural conditions, if T cells are present and B cell function is preserved

U2 - https://doi.org/10.1038/ni.3553

DO - https://doi.org/10.1038/ni.3553

M3 - Article

C2 - 27618553

SN - 1529-2908

VL - 17

SP - 1291

EP - 1299

JO - Nature immunology

JF - Nature immunology

IS - 11

ER -