Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum

Marit J. van Gils; Diana Edo-Matas; Emma J. Bowles; Judith A. Burger; Guillaume B. Stewart-Jones; Hanneke Schuitemaker

doi:https://doi.org/10.1128/JVI.05214-11

Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum

Marit J. van Gils, Diana Edo-Matas, Emma J. Bowles, Judith A. Burger, Guillaume B. Stewart-Jones, Hanneke Schuitemaker

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

Analysis of longitudinally obtained HIV-1 env sequences from an individual with reported cross-reactive neutralizing activity revealed that the majority of viral variants obtained from serum between 4 and 7 years after seroconversion were unable to persist in peripheral blood. Here we show that these viral variants were more sensitive to autologous serum neutralization, had shorter envelopes with fewer potential N-linked glycosylation sites, and showed lower replication kinetics than successfully evolving HIV-1 variants. These data reflect the host selection pressures on phenotypic characteristics of HIV-1 and illustrate in detail the dynamic interaction between HIV-1 and its host's humoral immune responses

Original language	English
Pages (from-to)	8443-8448
Journal	Journal of Virology
Volume	85
Issue number	16
DOIs	https://doi.org/10.1128/JVI.05214-11
Publication status	Published - 2011

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https://doi.org/10.1128/JVI.05214-11

Cite this

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title = "Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum",

abstract = "Analysis of longitudinally obtained HIV-1 env sequences from an individual with reported cross-reactive neutralizing activity revealed that the majority of viral variants obtained from serum between 4 and 7 years after seroconversion were unable to persist in peripheral blood. Here we show that these viral variants were more sensitive to autologous serum neutralization, had shorter envelopes with fewer potential N-linked glycosylation sites, and showed lower replication kinetics than successfully evolving HIV-1 variants. These data reflect the host selection pressures on phenotypic characteristics of HIV-1 and illustrate in detail the dynamic interaction between HIV-1 and its host's humoral immune responses",

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AU - Burger, Judith A.

AU - Stewart-Jones, Guillaume B.

AU - Schuitemaker, Hanneke

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AB - Analysis of longitudinally obtained HIV-1 env sequences from an individual with reported cross-reactive neutralizing activity revealed that the majority of viral variants obtained from serum between 4 and 7 years after seroconversion were unable to persist in peripheral blood. Here we show that these viral variants were more sensitive to autologous serum neutralization, had shorter envelopes with fewer potential N-linked glycosylation sites, and showed lower replication kinetics than successfully evolving HIV-1 variants. These data reflect the host selection pressures on phenotypic characteristics of HIV-1 and illustrate in detail the dynamic interaction between HIV-1 and its host's humoral immune responses

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DO - https://doi.org/10.1128/JVI.05214-11

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