Marit van Gils

PhD, (Principal Investigator)

20052024

Research activity per year

Personal profile

Research interests

The van Gils lab is committed to make a lasting impact on the field of vaccine immunology. Our mission is to comprehend the underlying immunology behind vaccination, in particular the elicitation of antibody responses. These antibody responses are vital in the protection against infectious diseases and the major goal in vaccine research is to induce potent antibodies. We believe that the protective effects of antibody responses are to a major extent imprinted during the first encounters of B and T cells with vaccines. Therefore, gaining knowledge and control over the initial interactions of vaccine candidates with B and T cells and the formation of germinal center responses, will guide the development and improvement of vaccines against infectious diseases. Therefore, we focus on determining phenotypic characteristics of B and Tfh cells and the interactions between these cells correlated with lifelong immunity after common childhood vaccines and after experimental vaccines. We use different techniques such as RNA sequencing, T and B cell receptor analysis and monoclonal antibody isolation to characterize the phenotype, affinity, and specificity of the antigen-specific B and T cells. Through this, we will provide new insights directed towards improving vaccines with the ultimate goal to elicit durable protective immune responses against infectious diseases, such as HIV, SARS-CoV-2, Hepatitis C virus and Influenza virus.

specialisation

vaccine immunology with the focus on antibodies

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

PhD, Virology, Universiteit van Amsterdam

1 Jan 200731 Dec 2011

Award Date: 1 Apr 2011

Master, Medical Pharmaceutical Sciences, Rijks Universiteit Groningen: Faculteit der Medische wetenschappen

1 Sept 200431 Aug 2006

Bachelor, Medical Pharmaceutical Science, Rijks Universiteit Groningen: Faculteit der Medische wetenschappen

1 Sept 200031 Aug 2004

External positions

Associate Editor for NPJ Vaccines

1 Jun 2022 → …

Board Member, The Netherlands Conference on HIV Pathogenesis

1 Jan 202031 Dec 2026

Member, Amsterdam UMC Research strategy advisory board

1 Jan 201931 Dec 2020

Member, Amsterdam Young Academy (AYA)

1 Jan 201831 Dec 2022

Keywords

  • QR355 Virology
  • QR180 Immunology

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
  • BG505 SOSIP.v5.2 in complex with rabbit Fab 43A2

    Nogal, B. (Contributor), McCoy, L. E. (Contributor), van Gils, M. (Contributor), Cottrell, C. A. (Contributor), Voss, J. E. (Contributor), Andrabi, R. (Contributor), Pauthner, M. (Contributor), Pauthner, M. (Contributor), Liang, C. (Contributor), Liang, C. (Contributor), Liang, C. (Contributor), Messmer, T. (Contributor), Nedellec, R. (Contributor), Shin, M. (Contributor), Turner, H. L. (Contributor), Ozorowski, G. (Contributor), Sanders, R. (Contributor), Burton, D. R. (Contributor), Ward, A. B. (Contributor), Ward, A. B. (Contributor) & Ward, A. B. (Contributor), Protein Data Bank (PDB), 1 Jul 2020

    Dataset

  • HIV-1 Envelope Glycoprotein BG505 SOSIP.664 expressed in HEK293S cells in complex with RM20A3 Fab

    Berndsen, Z. T. (Contributor), Chakraborty, S. (Contributor), Wang, X. (Contributor), Cottrell, C. A. (Contributor), Torres, J. L. (Contributor), Diedrich, J. K. (Contributor), López, C. A. (Contributor), Yates, J. R. (Contributor), van Gils, M. (Contributor), Paulson, J. C. (Contributor), Gnanakaran, S. (Contributor) & Ward, A. B. (Contributor), Protein Data Bank (PDB), 4 Nov 2020

    Dataset

  • ACS122 Fab

    van Schooten, J. (Contributor), Schorcht, A. (Contributor), Farokhi, E. (Contributor), Umotoy, J. (Contributor), Gao, H. (Contributor), van den Kerkhof, T. L. G. M. (Contributor), Dorning, J. (Contributor), Rijkhold Meesters, T. G. (Contributor), van der Woude, P. (Contributor), Burger, J. (Contributor), Bijl, T. (Contributor), Ghalaiyini, R. (Contributor), de la Peña, A. T. (Contributor), Turner, H. L. (Contributor), Labranche, C. C. (Contributor), Stanfield, R. L. (Contributor), Sok, D. (Contributor), Schuitemaker, H. (Contributor), Montefiori, D. C. (Contributor), Burton, D. R. (Contributor), Ozorowski, G. (Contributor), Seaman, M. S. (Contributor), Wilson, I. A. (Contributor), Sanders, R. (Contributor), Ward, A. B. (Contributor) & van Gils, M. (Contributor), Protein Data Bank (PDB), 2 Nov 2022

    Dataset

  • AMC016 SOSIP.v4.2 in complex with PGV04 Fab

    Schorcht, A. (Contributor), Cottrell, C. A. (Contributor), Pugach, P. (Contributor), Ringe, R. P. (Contributor), Han, A. X. (Contributor), Allen, J. D. (Contributor), van den Kerkhof, T. L. G. M. (Contributor), Seabright, G. E. (Contributor), Schermer, E. E. (Contributor), Ketas, T. J. (Contributor), Burger, J. (Contributor), van Schooten, J. (Contributor), LaBranche, C. C. (Contributor), Ozorowski, G. (Contributor), de Val, N. (Contributor), Bader, D. L. V. (Contributor), Schuitemaker, H. (Contributor), Russell, C. A. (Contributor), Montefiori, D. C. (Contributor), van Gils, M. (Contributor), Crispin, M. (Contributor), Klasse, P. J. (Contributor), Ward, A. B. (Contributor), Moore, J. P. (Contributor) & Sanders, R. (Contributor), Protein Data Bank (PDB), 15 Sept 2021

    Dataset

  • Trimeric SARS-CoV-2 spike ectodomain in complex with biliverdin (closed conformation)

    Rosa, A. (Contributor), Pye, V. E. (Contributor), Graham, C. (Contributor), Muir, L. (Contributor), Seow, J. (Contributor), Ng, K. W. (Contributor), Cook, N. J. (Contributor), Rees-Spear, C. (Contributor), Parker, E. (Contributor), dos Santos, M. S. (Contributor), Rosadas, C. (Contributor), Susana, A. (Contributor), Rhys, H. (Contributor), Nans, A. (Contributor), Masino, L. (Contributor), Roustan, C. (Contributor), Christodoulou, E. (Contributor), Ulferts, R. (Contributor), Wrobel, A. G. (Contributor), Short, C. (Contributor), Fertleman, M. (Contributor), Sanders, R. (Contributor), Heaney, J. (Contributor), Spyer, M. (Contributor), Kjær, S. (Contributor), Riddell, A. (Contributor), Malim, M. H. (Contributor), Beale, R. (Contributor), MacRae, J. I. (Contributor), Taylor, G. P. (Contributor), Nastouli, E. (Contributor), van Gils, M. (Contributor), Rosenthal, P. B. (Contributor), Pizzato, M. (Contributor), McClure, M. O. (Contributor), Tedder, R. S. (Contributor), Kassiotis, G. (Contributor), McCoy, L. E. (Contributor), Doores, K. J. (Contributor) & Cherepanov, P. (Contributor), Protein Data Bank (PDB), 28 Apr 2021

    Dataset