TY - CHAP
T1 - Examination of the Role of Galectins and Galectin Inhibitors in Endothelial Cell Biology
AU - Castricum, Kitty C.M.
AU - Thijssen, Victor L.J.L.
N1 - Publisher Copyright: © 2022, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022
Y1 - 2022
N2 - The growth of new blood vessels is a key event in many (patho) physiological processes, including embryogenesis, wound healing, inflammatory diseases, and cancer. Neovascularization requires different, well-coordinated actions of endothelial cells, i.e., the cells lining the luminal side of all blood vessels. Galectins are involved in several of these activities. In this chapter, we describe methods to study galectins in three key functions of endothelial cells during angiogenesis, i.e., endothelial cell migration, endothelial cell sprouting, and endothelial cell network formation.
AB - The growth of new blood vessels is a key event in many (patho) physiological processes, including embryogenesis, wound healing, inflammatory diseases, and cancer. Neovascularization requires different, well-coordinated actions of endothelial cells, i.e., the cells lining the luminal side of all blood vessels. Galectins are involved in several of these activities. In this chapter, we describe methods to study galectins in three key functions of endothelial cells during angiogenesis, i.e., endothelial cell migration, endothelial cell sprouting, and endothelial cell network formation.
KW - Angiogenesis
KW - Endothelial cell
KW - Galectin
KW - Migration
KW - Network formation
KW - Sprouting
UR - http://www.scopus.com/inward/record.url?scp=85126882892&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/978-1-0716-2055-7_35
DO - https://doi.org/10.1007/978-1-0716-2055-7_35
M3 - Chapter
C2 - 35320551
T3 - Methods in Molecular Biology
SP - 655
EP - 662
BT - Methods in Molecular Biology
PB - Humana Press Inc.
ER -