Research output per year
Research output per year
Personal profile
specialisation
Angiogenesis
Radiobiology
Molecular Cell Biology
Glycobiology
Research interests
My group is interested in deciphering the molecular response mechanisms to clinical schedules of fractionated radiotherapy. The overarching goal is to understand how tumor cells and the tumor micro-environment respond during longer periods of fractionated radiotherapy in order to optimize dose-scheduling of combination therapies.
Over the last decade, we have used different approaches to determine the role of the tumor microenvironment in the response to radiotherapy and to monitor the cellular response(s) of the tumor microenvironment to radiotherapy. This includes studies in cultured cell in vitro, in tumor models in vivo as well as in tumor tissues derived from cancer patients.
Regarding the modulation of the tumor micro-environment, we are particularly interested in the role of galectins, a family of carbohydrate (sugar) binding proteins that are linked to blood vessel growth as well as to regulation of the immune response. We study how galectins contribute to tumor progression and how targeting galectins can be exploited for cancer therapy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Postdoc, Maastricht UMC
2002 → 2009
PhD student, Maastricht UMC
1997 → 2002
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Prediction of pathologic complete response after single-dose MR-guided partial breast irradiation in low-risk breast cancer patients: the ABLATIVE-2 trial—a study protocol
Civil, Y. A., Oei, A. L., Duvivier, K. M., Bijker, N., Meijnen, P., Donkers, L., Verheijen, S., van Kesteren, Z., Palacios, M. A., Schijf, L. J., Barbé, E., Konings, I. R. H. M., van der Houven van Oordt, C. W. M., Westhoff, P. G., Meijer, H. J. M., Diepenhorst, G. M. P., Thijssen, V., Mouliere, F., Slotman, B. J., van der Velde, S., & 1 others, 1 Dec 2023, In: BMC Cancer. 23, 1, 419.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy
Nowak-Sliwinska, P., van Beijnum, J. R., Griffioen, C. J., Huinen, Z. R., Sopesens, N. G., Schulz, R., Jenkins, S. V., Dings, R. P. M., Groenendijk, F. H., Huijbers, E. J. M., Thijssen, V. L. J. L., Jonasch, E., Vyth-Dreese, F. A., Jordanova, E. S., Bex, A., Bernards, R., de Gruijl, T. D. & Griffioen, A. W., May 2023, In: Angiogenesis. 26, 2, p. 279-293 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access13 Citations (Scopus) -
A phase Ib/II study of regorafenib and paclitaxel in patients with beyond first-line advanced esophagogastric carcinoma (REPEAT)
Stroes, C. I., Schokker, S., Khurshed, M., van der Woude, S. O., Mathôt, R. A. A., Slingerland, M., de Vos-Geelen, J., Zucchetti, M., Matteo, C., van Dijk, E., Ylstra, B., Thijssen, V., Derks, S., Godefa, T., Dijksterhuis, W., Breimer, G. E., van Delden, O. M., Verhoeven, R. H. A., Meijer, S. L., Bijlsma, M. F., & 1 others, 2022, In: Therapeutic advances in medical oncology. 14Research output: Contribution to journal › Article › Academic › peer-review
Open Access3 Citations (Scopus) -
C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration
Hartl, L., Maarschalkerweerd, P. A. F., Butler, J. M., Manz, X. D., Thijssen, V. L. J. L., Bijlsma, M. F., Duitman, J. & Spek, C. A., 1 Nov 2022, In: Cells. 11, 21, 3334.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
Correction to: Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden (Cancer Immunology, Immunotherapy, (2022), 71, 8, (2029-2040), 10.1007/s00262-021-03139-4)
Femel, J., van Hooren, L., Herre, M., Cedervall, J., Saupe, F., Huijbers, E. J. M., Verboogen, D. R. J., Reichel, M., Thijssen, V. L., Griffioen, A. W., Hellman, L., Dimberg, A. & Olsson, A-K., Oct 2022, In: Cancer Immunology, Immunotherapy. 71, 10, p. 2581 1 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic
Open Access2 Citations (Scopus)
Datasets
-
Additional file 2 of Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation
Goedegebuure, R. S. A. (Creator), Kleibeuker, E. A. (Creator), Buffa, F. M. (Creator), Castricum, K. C. M. (Creator), Haider, S. (Creator), Schulkens, I. A. (Creator), ten Kroode, L. (Contributor), van den Berg, J. (Contributor), Jacobs, M. (Creator), van Berkel, A. (Contributor), van Grieken, N. (Contributor), Derks, S. (Creator), Slotman, B. (Creator), Verheul, H. M. W. (Creator), Harris, A. L. (Creator) & Thijssen, V. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.14561378.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Interferon-_and_STING-independent_induction_of_type_I_interferon_stimulated_genes_during_fractionated_irradiation/14561378/1
Dataset
-
Additional file 2 of Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation
Goedegebuure, R. S. A. (Creator), Kleibeuker, E. A. (Creator), Buffa, F. M. (Creator), Castricum, K. C. M. (Creator), Haider, S. (Creator), Schulkens, I. A. (Creator), ten Kroode, L. (Contributor), van den Berg, J. (Contributor), Jacobs, M. (Creator), van Berkel, A. (Contributor), van Grieken, N. (Contributor), Derks, S. (Creator), Slotman, B. (Creator), Verheul, H. M. W. (Creator), Harris, A. L. (Creator) & Thijssen, V. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.14561378, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Interferon-_and_STING-independent_induction_of_type_I_interferon_stimulated_genes_during_fractionated_irradiation/14561378
Dataset
-
Painting proteins to study cardiovascular pathology
Victor Thijssen (Examiner)
24 Feb 2022Activity: PhD thesis Examination › Examination › Educational
-
Targeted chemoprevention of head and neck cancer
Victor Thijssen (Examiner)
25 Jan 2021Activity: PhD thesis Examination › Examination › Educational
-
Amsterdam UMC (Organisational unit)
Victor Thijssen (Chair)
2020 → 2022Activity: Membership › Membership of board › Academic
-
Tumor-associated glycan structures: friend or foe in immunity to cancer?
Victor Thijssen (Examiner)
2 Jul 2019Activity: PhD thesis Examination › Examination › Educational
-
Immunotherapy and combined treatment approaches to angiogenesis inhibition
Victor Thijssen (Examiner)
11 Jun 2019Activity: PhD thesis Examination › Examination › Educational