Fatal Scedosporium prolificans infection in a leukemic patient

M. C. Feltkamp; M. J. Kersten; J. van der Lelie; J. D. Burggraaf; G. S. de Hoog; E. J. Kuijper

doi:https://doi.org/10.1007/BF02471912

Fatal Scedosporium prolificans infection in a leukemic patient

M. C. Feltkamp, M. J. Kersten, J. van der Lelie, J. D. Burggraaf, G. S. de Hoog, E. J. Kuijper

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Abstract

The case is described of a 42-year-old patient with acute myeloid leukemia who received two courses of chemotherapy complicated by prolonged bone marrow depression. He was admitted to hospital with fever, hepatosplenomegaly and bilateral nodular pulmonary infiltrates. After admission diffuse cutaneous skin nodules, and hypodense lesions in the hemispheres and cerebellum developed. Cultures of cerebrospinal fluid, bronchoalveolar lavage fluid, skin biopsy specimens and blood revealed Scedosporium prolificans, indicative of disseminated mycosis. Treatment with amphotericin B and fluconazole was unsuccessful and the patient died within five days after admission. Features that may enhance early recognition of Scedosporium prolificans infection by both clinicians and microbiologists, as well as options in the treatment of infection with this fungal agent are discussed

Original language	English
Pages (from-to)	460-464
Journal	European journal of clinical microbiology & infectious diseases
Volume	16
Issue number	6
DOIs	https://doi.org/10.1007/BF02471912
Publication status	Published - 1997

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https://doi.org/10.1007/BF02471912

Cite this

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title = "Fatal Scedosporium prolificans infection in a leukemic patient",

abstract = "The case is described of a 42-year-old patient with acute myeloid leukemia who received two courses of chemotherapy complicated by prolonged bone marrow depression. He was admitted to hospital with fever, hepatosplenomegaly and bilateral nodular pulmonary infiltrates. After admission diffuse cutaneous skin nodules, and hypodense lesions in the hemispheres and cerebellum developed. Cultures of cerebrospinal fluid, bronchoalveolar lavage fluid, skin biopsy specimens and blood revealed Scedosporium prolificans, indicative of disseminated mycosis. Treatment with amphotericin B and fluconazole was unsuccessful and the patient died within five days after admission. Features that may enhance early recognition of Scedosporium prolificans infection by both clinicians and microbiologists, as well as options in the treatment of infection with this fungal agent are discussed",

author = "Feltkamp, {M. C.} and Kersten, {M. J.} and {van der Lelie}, J. and Burggraaf, {J. D.} and {de Hoog}, {G. S.} and Kuijper, {E. J.}",

year = "1997",

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T1 - Fatal Scedosporium prolificans infection in a leukemic patient

AU - Feltkamp, M. C.

AU - Kersten, M. J.

AU - van der Lelie, J.

AU - Burggraaf, J. D.

AU - de Hoog, G. S.

AU - Kuijper, E. J.

PY - 1997

Y1 - 1997

N2 - The case is described of a 42-year-old patient with acute myeloid leukemia who received two courses of chemotherapy complicated by prolonged bone marrow depression. He was admitted to hospital with fever, hepatosplenomegaly and bilateral nodular pulmonary infiltrates. After admission diffuse cutaneous skin nodules, and hypodense lesions in the hemispheres and cerebellum developed. Cultures of cerebrospinal fluid, bronchoalveolar lavage fluid, skin biopsy specimens and blood revealed Scedosporium prolificans, indicative of disseminated mycosis. Treatment with amphotericin B and fluconazole was unsuccessful and the patient died within five days after admission. Features that may enhance early recognition of Scedosporium prolificans infection by both clinicians and microbiologists, as well as options in the treatment of infection with this fungal agent are discussed

AB - The case is described of a 42-year-old patient with acute myeloid leukemia who received two courses of chemotherapy complicated by prolonged bone marrow depression. He was admitted to hospital with fever, hepatosplenomegaly and bilateral nodular pulmonary infiltrates. After admission diffuse cutaneous skin nodules, and hypodense lesions in the hemispheres and cerebellum developed. Cultures of cerebrospinal fluid, bronchoalveolar lavage fluid, skin biopsy specimens and blood revealed Scedosporium prolificans, indicative of disseminated mycosis. Treatment with amphotericin B and fluconazole was unsuccessful and the patient died within five days after admission. Features that may enhance early recognition of Scedosporium prolificans infection by both clinicians and microbiologists, as well as options in the treatment of infection with this fungal agent are discussed

U2 - https://doi.org/10.1007/BF02471912

DO - https://doi.org/10.1007/BF02471912

M3 - Article

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JO - European journal of clinical microbiology & infectious diseases

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