Fluorine-18 labelled Ruppert-Prakash reagent ([18F]Me3SiCF3) for the synthesis of 18F-trifluoromethylated compounds

Anna Pees, Maria J. W. D. Vosjan, Neil Vasdev, Albert D. Windhorst, Danielle J. Vugts

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7 Citations (Scopus)


This article describes the first synthesis and application of fluorine-18 labelled Ruppert-Prakash reagent [18F]Me3SiCF3. [18F]Me3SiCF3 was synthesized from [18F]fluoroform with radiochemical yields of 85-95% and radiochemical purities of >95% within 20 minutes. 18F-trifluoromethylated compounds were successfully prepared by reaction of [18F]Me3SiCF3 with benzaldehydes, acetophenones and benzophenones. This journal is
Original languageEnglish
Article number01789
Pages (from-to)5286-5289
Number of pages4
JournalChemical Communications
Issue number43
Publication statusPublished - 28 May 2021

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