TY - JOUR
T1 - Fluorine-18 labelled Ruppert-Prakash reagent ([18F]Me3SiCF3) for the synthesis of 18F-trifluoromethylated compounds
AU - Pees, Anna
AU - Vosjan, Maria J. W. D.
AU - Vasdev, Neil
AU - Windhorst, Albert D.
AU - Vugts, Danielle J.
N1 - Funding Information: The project is financially supported by the Dutch Research Council (NWO) grant no. 731.015.413 and BV Cyclotron VU. We also thank the Azrieli Foundation, Canada Foundation for Innovation, Ontario Research Fund and the Canada Research Chairs Program as well as members of the CAMH Brain Health Imaging Centre for support. Publisher Copyright: © The Royal Society of Chemistry. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/28
Y1 - 2021/5/28
N2 - This article describes the first synthesis and application of fluorine-18 labelled Ruppert-Prakash reagent [18F]Me3SiCF3. [18F]Me3SiCF3 was synthesized from [18F]fluoroform with radiochemical yields of 85-95% and radiochemical purities of >95% within 20 minutes. 18F-trifluoromethylated compounds were successfully prepared by reaction of [18F]Me3SiCF3 with benzaldehydes, acetophenones and benzophenones. This journal is
AB - This article describes the first synthesis and application of fluorine-18 labelled Ruppert-Prakash reagent [18F]Me3SiCF3. [18F]Me3SiCF3 was synthesized from [18F]fluoroform with radiochemical yields of 85-95% and radiochemical purities of >95% within 20 minutes. 18F-trifluoromethylated compounds were successfully prepared by reaction of [18F]Me3SiCF3 with benzaldehydes, acetophenones and benzophenones. This journal is
UR - http://www.scopus.com/inward/record.url?scp=85106995987&partnerID=8YFLogxK
U2 - https://doi.org/10.1039/d1cc01789f
DO - https://doi.org/10.1039/d1cc01789f
M3 - Article
C2 - 33942818
SN - 1359-7345
VL - 57
SP - 5286
EP - 5289
JO - Chemical Communications
JF - Chemical Communications
IS - 43
M1 - 01789
ER -