TY - JOUR
T1 - Fluticasone furoate nasal spray reduces symptoms of uncomplicated acute rhinosinusitis: a randomised placebo-controlled study
AU - Keith, Paul K.
AU - Dymek, Andrzej
AU - Pfaar, Oliver
AU - Fokkens, Wytske
AU - Yun Kirby, Suyong
AU - Wu, Wei
AU - Garris, Cindy
AU - Topors, Nazli
AU - Lee, Laurie A.
PY - 2012
Y1 - 2012
N2 - Background: Uncomplicated acute rhinosinusitis (ARS) is usually a self-limiting inflammatory condition often treated with antibiotics. Aims: To assess the safety and efficacy of fluticasone furoate nasal spray (FFNS) compared with placebo for symptomatic relief of uncomplicated ARS. Methods: A randomised, double-blind, placebo-controlled, parallel-group, multicentre, 2-week treatment study of FFNS 110 mu g once and twice daily was undertaken in adults/adolescents. Results: A statistically significant reduction was seen in the daily major symptoms score, a composite score of three individual symptoms (nasal congestion/stuffiness, sinus headache/pressure or facial pain/pressure, and postnasal drip on a 0-3 scale) by both FFNS doses compared with placebo (least square mean differences vs. placebo of -0.386 (p=0.008) and -0.357 (p=0.014) for once daily and twice daily FFNS, respectively). The differences in median times to symptom improvement were not statistically significant between each dose of FFNS (7 days) and placebo (8 days). There were no treatment differences in antibiotic use for possible fulminant bacterial rhinosinusitis (3% in each group). The safety profile of FFNS was similar to placebo. Conclusions: FFNS reduces symptoms of uncomplicated ARS compared with placebo and is well tolerated, providing support for withholding antibiotics in selected patients. (C) 2012 Primary Care Respiratory Society UK. All rights reserved. PK Keith et al. Prim Care Respir J 2012; 21(3): 267-275 http://dx.doi.org/10.4104/pcrj.2012.00039
AB - Background: Uncomplicated acute rhinosinusitis (ARS) is usually a self-limiting inflammatory condition often treated with antibiotics. Aims: To assess the safety and efficacy of fluticasone furoate nasal spray (FFNS) compared with placebo for symptomatic relief of uncomplicated ARS. Methods: A randomised, double-blind, placebo-controlled, parallel-group, multicentre, 2-week treatment study of FFNS 110 mu g once and twice daily was undertaken in adults/adolescents. Results: A statistically significant reduction was seen in the daily major symptoms score, a composite score of three individual symptoms (nasal congestion/stuffiness, sinus headache/pressure or facial pain/pressure, and postnasal drip on a 0-3 scale) by both FFNS doses compared with placebo (least square mean differences vs. placebo of -0.386 (p=0.008) and -0.357 (p=0.014) for once daily and twice daily FFNS, respectively). The differences in median times to symptom improvement were not statistically significant between each dose of FFNS (7 days) and placebo (8 days). There were no treatment differences in antibiotic use for possible fulminant bacterial rhinosinusitis (3% in each group). The safety profile of FFNS was similar to placebo. Conclusions: FFNS reduces symptoms of uncomplicated ARS compared with placebo and is well tolerated, providing support for withholding antibiotics in selected patients. (C) 2012 Primary Care Respiratory Society UK. All rights reserved. PK Keith et al. Prim Care Respir J 2012; 21(3): 267-275 http://dx.doi.org/10.4104/pcrj.2012.00039
U2 - https://doi.org/10.4104/pcrj.2012.00039
DO - https://doi.org/10.4104/pcrj.2012.00039
M3 - Article
C2 - 22614920
SN - 1471-4418
VL - 21
SP - 267
EP - 275
JO - Primary care respiratory journal
JF - Primary care respiratory journal
IS - 3
ER -