TY - JOUR
T1 - Free-Choice and No-Choice High-Fat Diets Affect Striatal Dopamine D-2/3 Receptor Availability, Caloric Intake, and Adiposity
AU - van de Giessen, Elsmarieke
AU - la Fleur, Susanne E.
AU - de Bruin, Kora
AU - van den Brink, Wim
AU - Booij, Jan
PY - 2012
Y1 - 2012
N2 - Different types of high-fat (HF) diets are used to study diet-induced obesity (DIO) in rodents and this has led to different phenotypes. This study assesses whether different HF diets differentially affect striatal dopamine D-2/3 receptor (DRD2/3) availability, as decreased striatal DRD2/3 availability has been implicated in obesity in relation to reward deficiency for food. Thirty rats were randomized to either a free-choice HF diet (HF-choice), a premixed HF diet (HF-no-choice), or a standard chow diet for 28 days. Striatal DRD2/3 was measured using 123I-IBZM storage phosphor imaging at day 29. DRD2/3 availability was significantly decreased in the dorsal striatum in the HF-choice rats compared to chow rats, but not in HF-no-choice rats. Additionally, caloric intake of the HF-choice rats was significantly higher than that of HF-no-choice rats and serum leptin and percentage abdominal fat store weight of total body weight were significantly higher in the HF-choice rats compared to chow rats. These preliminary results suggest that the choice element in HF diets, which is possibly related to the motivational aspects of eating, leads to overconsumption and to a distinct state of obesity. These results are relevant for future studies on DIO when considering choice of diet type
AB - Different types of high-fat (HF) diets are used to study diet-induced obesity (DIO) in rodents and this has led to different phenotypes. This study assesses whether different HF diets differentially affect striatal dopamine D-2/3 receptor (DRD2/3) availability, as decreased striatal DRD2/3 availability has been implicated in obesity in relation to reward deficiency for food. Thirty rats were randomized to either a free-choice HF diet (HF-choice), a premixed HF diet (HF-no-choice), or a standard chow diet for 28 days. Striatal DRD2/3 was measured using 123I-IBZM storage phosphor imaging at day 29. DRD2/3 availability was significantly decreased in the dorsal striatum in the HF-choice rats compared to chow rats, but not in HF-no-choice rats. Additionally, caloric intake of the HF-choice rats was significantly higher than that of HF-no-choice rats and serum leptin and percentage abdominal fat store weight of total body weight were significantly higher in the HF-choice rats compared to chow rats. These preliminary results suggest that the choice element in HF diets, which is possibly related to the motivational aspects of eating, leads to overconsumption and to a distinct state of obesity. These results are relevant for future studies on DIO when considering choice of diet type
U2 - https://doi.org/10.1038/oby.2012.17
DO - https://doi.org/10.1038/oby.2012.17
M3 - Article
C2 - 22307070
SN - 1930-7381
VL - 20
SP - 1738
EP - 1740
JO - Obesity (Silver Spring, Md.)
JF - Obesity (Silver Spring, Md.)
IS - 8
ER -