TY - JOUR
T1 - Frontostriatal system in planning complexity
T2 - A parametric functional magnetic resonance version of Tower of London task
AU - Van Den Heuvel, Odile A.
AU - Groenewegen, Henk J.
AU - Barkhof, Frederik
AU - Lazeron, Richard H.C.
AU - Van Dyck, Richard
AU - Veltman, Dick J.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - In the present study, we sought to investigate which brain structures are recruited in planning tasks of increasing complexity. For this purpose, a parametric self-paced pseudo-randomized event-related functional MRI version of the Tower of London task was designed. We tested 22 healthy subjects, enabling assessment of imaging results at a second (random effects) level of analysis. Compared with baseline, planning activity was correlated with increased blood oxygenation level-dependent (BOLD) signal in the dorsolateral prefrontal cortex, striatum, premotor cortex, supplementary motor area, and visuospatial system (precuneus and inferior parietal cortex). Task load was associated with increased activity in these same regions. In addition, increasing task complexity was correlated with activity in the left anterior prefrontal cortex, a region supposed to be specifically involved in third-order higher cognitive functioning.
AB - In the present study, we sought to investigate which brain structures are recruited in planning tasks of increasing complexity. For this purpose, a parametric self-paced pseudo-randomized event-related functional MRI version of the Tower of London task was designed. We tested 22 healthy subjects, enabling assessment of imaging results at a second (random effects) level of analysis. Compared with baseline, planning activity was correlated with increased blood oxygenation level-dependent (BOLD) signal in the dorsolateral prefrontal cortex, striatum, premotor cortex, supplementary motor area, and visuospatial system (precuneus and inferior parietal cortex). Task load was associated with increased activity in these same regions. In addition, increasing task complexity was correlated with activity in the left anterior prefrontal cortex, a region supposed to be specifically involved in third-order higher cognitive functioning.
KW - Basal ganglia
KW - Functional magnetic resonance imaging
KW - Parametric
KW - Planning
KW - Prefrontal cortex
KW - Tower of London
UR - http://www.scopus.com/inward/record.url?scp=0037330725&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/S1053-8119(02)00010-1
DO - https://doi.org/10.1016/S1053-8119(02)00010-1
M3 - Article
C2 - 12595190
SN - 1053-8119
VL - 18
SP - 367
EP - 374
JO - NEUROIMAGE
JF - NEUROIMAGE
IS - 2
ER -