Functional Outcomes and Health-Related Quality of Life Following Glioma Surgery

Philip C De Witt Hamer, Philip C De Witt Hamer, Martin Klein, Shawn L Hervey-Jumper, Jeffrey S Wefel, Mitchel S Berger

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)


Functional outcome following glioma surgery is defined as how the patient functions or feels. Functional outcome is a coprimary end point of surgery in patients with diffuse glioma, together with oncological outcome. In this review, we structure the functional outcome measurements following glioma surgery as reported in the last 5 yr. We review various perspectives on functional outcome of glioma surgery with available measures, and offer suggestions for their use. From the recent neurosurgical literature, 160 publications were retrieved fulfilling the selection criteria. In these publications, neurological outcomes were reported most often, followed by activities of daily living, seizure outcomes, neurocognitive outcomes, and health-related quality of life or well-being. In more than a quarter of these publications functional outcome was not reported. A minimum essential consensus set of functional outcome measurements would benefit comparison across neurosurgical reports. The consensus set should be based on a combination of clinician- and patient-reported outcomes, assessed at a predefined time before and after surgery. The selected measurements should have psychometric properties supporting the intended use including validity-related evidence, reliability, and sensitivity to detect meaningful change with minimal burden to ensure compliance. We circulate a short survey as a start towards reporting guidelines. Many questions remain to better understand, report, and improve functional outcome following glioma surgery.

Original languageEnglish
Pages (from-to)720-732
Number of pages13
Issue number4
Early online date30 Jan 2021
Publication statusPublished - 1 Apr 2021


  • Craniotomy
  • Glioma
  • Neurosurgical procedures
  • Patient outcome assessment
  • Patient-reported outcome measures
  • Quality of life
  • Treatment outcome

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