Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

Victor L J L Thijssen; Ruben Postel; Ricardo J M G E Brandwijk; Ruud P M Dings; Irina Nesmelova; Sietske Satijn; Nicole Verhofstad; Yusaku Nakabeppu; Linda G Baum; Jeroen Bakkers; Kevin H Mayo; Françoise Poirier; Arjan W Griffioen

doi:https://doi.org/10.1073/pnas.0603883103

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

Victor L J L Thijssen, Ruben Postel, Ricardo J M G E Brandwijk, Ruud P M Dings, Irina Nesmelova, Sietske Satijn, Nicole Verhofstad, Yusaku Nakabeppu, Linda G Baum, Jeroen Bakkers, Kevin H Mayo, Françoise Poirier, Arjan W Griffioen

Research output: Contribution to journal › Article › Academic › peer-review

410 Citations (Scopus)

Abstract

We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.

Original language	English
Pages (from-to)	15975-80
Number of pages	6
Journal	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume	103
Issue number	43
DOIs	https://doi.org/10.1073/pnas.0603883103
Publication status	Published - 24 Oct 2006
Externally published	Yes

Keywords

Animals
Cell Movement
Cell Proliferation
Cells, Cultured
Disease Progression
Endothelial Cells/metabolism
Galectin 1/deficiency
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Knockout
Neoplasm Transplantation
Neoplasms/blood supply
Protein Binding
Proteins/metabolism
Zebrafish

Access to Document

https://doi.org/10.1073/pnas.0603883103

Cite this

Thijssen, V. L. J. L., Postel, R., Brandwijk, R. J. M. G. E., Dings, R. P. M., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L. G., Bakkers, J., Mayo, K. H., Poirier, F., & Griffioen, A. W. (2006). Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(43), 15975-80. https://doi.org/10.1073/pnas.0603883103

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title = "Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy",

abstract = "We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.",

keywords = "Animals, Cell Movement, Cell Proliferation, Cells, Cultured, Disease Progression, Endothelial Cells/metabolism, Galectin 1/deficiency, Gene Expression Regulation, Neoplastic, Humans, Mice, Mice, Knockout, Neoplasm Transplantation, Neoplasms/blood supply, Protein Binding, Proteins/metabolism, Zebrafish",

author = "Thijssen, {Victor L J L} and Ruben Postel and Brandwijk, {Ricardo J M G E} and Dings, {Ruud P M} and Irina Nesmelova and Sietske Satijn and Nicole Verhofstad and Yusaku Nakabeppu and Baum, {Linda G} and Jeroen Bakkers and Mayo, {Kevin H} and Fran{\c c}oise Poirier and Griffioen, {Arjan W}",

year = "2006",

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doi = "https://doi.org/10.1073/pnas.0603883103",

language = "English",

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Thijssen, VLJL, Postel, R, Brandwijk, RJMGE, Dings, RPM, Nesmelova, I, Satijn, S, Verhofstad, N, Nakabeppu, Y, Baum, LG, Bakkers, J, Mayo, KH, Poirier, F & Griffioen, AW 2006, 'Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103, no. 43, pp. 15975-80. https://doi.org/10.1073/pnas.0603883103

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. / Thijssen, Victor L J L; Postel, Ruben; Brandwijk, Ricardo J M G E et al.
In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 103, No. 43, 24.10.2006, p. 15975-80.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

AU - Thijssen, Victor L J L

AU - Postel, Ruben

AU - Brandwijk, Ricardo J M G E

AU - Dings, Ruud P M

AU - Nesmelova, Irina

AU - Satijn, Sietske

AU - Verhofstad, Nicole

AU - Nakabeppu, Yusaku

AU - Baum, Linda G

AU - Bakkers, Jeroen

AU - Mayo, Kevin H

AU - Poirier, Françoise

AU - Griffioen, Arjan W

PY - 2006/10/24

Y1 - 2006/10/24

N2 - We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.

AB - We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.

KW - Animals

KW - Cell Movement

KW - Cell Proliferation

KW - Cells, Cultured

KW - Disease Progression

KW - Endothelial Cells/metabolism

KW - Galectin 1/deficiency

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Mice

KW - Mice, Knockout

KW - Neoplasm Transplantation

KW - Neoplasms/blood supply

KW - Protein Binding

KW - Proteins/metabolism

KW - Zebrafish

U2 - https://doi.org/10.1073/pnas.0603883103

DO - https://doi.org/10.1073/pnas.0603883103

M3 - Article

C2 - 17043243

SN - 0027-8424

VL - 103

SP - 15975

EP - 15980

JO - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IS - 43

ER -