TY - JOUR
T1 - Gender-related neuroanatomical differences in alcohol dependence
T2 - findings from the ENIGMA Addiction Working Group
AU - Rossetti, Maria Gloria
AU - Patalay, Praveetha
AU - Mackey, Scott
AU - Allen, Nicholas B
AU - Batalla, Albert
AU - Bellani, Marcella
AU - Chye, Yann
AU - Cousijn, Janna
AU - Goudriaan, Anna E
AU - Hester, Robert
AU - Hutchison, Kent
AU - Li, Chiang-Shan R
AU - Martin-Santos, Rocio
AU - Momenan, Reza
AU - Sinha, Rajita
AU - Schmaal, Lianne
AU - Sjoerds, Zsuzsika
AU - Solowij, Nadia
AU - Suo, Chao
AU - van Holst, Ruth J
AU - Veltman, Dick J
AU - Yücel, Murat
AU - Thompson, Paul M
AU - Conrod, Patricia
AU - Garavan, Hugh
AU - Brambilla, Paolo
AU - Lorenzetti, Valentina
N1 - Funding Information: Data collection: Drs. Sjoerds and Veltman received funding from Netherlands Organization for Health Research and Development (ZonMW) grant 31160004 from NWO. Drs. Goudriaan and van Holst received funding from ZonMW grant 91676084 from NWO. Drs. Cousijn and Goudriaan received funding for the Cannabis Prospective study from ZonMW grant 31180002 from NWO. Dr. Momenan was supported by the Intramural Clinical and Biological Research Program of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Dr. Sinha received funds from NIDA (PL30-1DA024859-01), the NIH National Center for Research Resources (UL1-RR24925-01), and NIAAA (R01-AA013892). Dr. Solowij received funding from the Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council Project grant 459111 and was supported by Australian Research Council Future Fellowship FT110100752. Prof. Yücel was supported by National Health and Medical Research Council Fellowship 1117188 and the David Winston Turner Endowment Fund. Dr Lorenzetti was supported by The Australian Catholic University through a competitive scheme. Funding Information: P.T. received partial grant support from Biogen, Inc. (Boston, USA) for research unrelated to this manuscript. M.Y. has received funding from several law firms in relation to expert witness reports. Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/3/22
Y1 - 2021/3/22
N2 - Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3-9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence.
AB - Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3-9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence.
UR - http://www.scopus.com/inward/record.url?scp=85104072431&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.nicl.2021.102636
DO - https://doi.org/10.1016/j.nicl.2021.102636
M3 - Article
C2 - 33857771
SN - 2213-1582
VL - 30
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 102636
ER -