Genetic loci influencing kidney function and chronic kidney disease

J.C. Chambers; W.H. Zhang; G.M. Lord; P. van der Harst; D.A. Lawlor; J.S. Sehmi; D.P. Gale; M.N. Wass; K.R. Ahmadi; J. L. Bakker; J. Beckmann; H.J.G. Bilo; M. Bochud; M.J. Brown; M.J. Caulfield; J.M.C. Connell; H.T. Cook; I. Cotlarciuc; G.D. Smith; R. de Silva; G.H. Deng; O. Devuyst; L.D. Dikkeschei; N. Dimkovic; M. Dockrell; A. Dominiczak; S. Ebrahim; T. Eggermann; M. Farrall; L. Ferrucci; J. Floege; N.G. Forouhi; R.T. Gansevoort; X.J. Han; B. Hedblad; J.J.H. van der Heide; B.G. Hepkema; M. Hernandez-Fuentes; E. Hypponen; T. Johnson; P.E. de Jong; N. Kleefstra; V. Lagou; M. Lapsley; Y. Li; R.J.F. Loos; J. Luan; K. Luttropp; C. Marechal; O. Melander; P.B. Munroe; L. Nordfors; A. Parsa; L. Peltonen; B.W.J.H. Penninx; E. Perucha; A. Pouta; I. Prokopenko; P.J. Roderick; A. Ruokonen; N.J. Samani; S. Sanna; M. Schalling; D. Schlessinger; G. Schlieper; M.A.J. Seelen; A.R. Shuldiner; M. Sjogren; J.H. Smit; H. Snieder; N. Soranzo; T.D. Spector; P. Stenvinkel; M.J.E. Sternberg; R. Swaminathan; T. Tanaka; L.J. Ubink-Veltmaat; M. Uda; P. Vollenweider; C. Wallace; D. Waterworth; K. Zerres; G. Waeber; N.J. Wareham; P.H. Maxwell; M.I. McCarthy; M.R. Jarvelin; V. Mooser; G.R. Abecasis; L. Lightstone; J. Scott; G. Navis; P. Elliott; J.S. Kooner; Marketa Sjögren

doi:https://doi.org/10.1038/ng.566

Genetic loci influencing kidney function and chronic kidney disease

J.C. Chambers, W.H. Zhang, G.M. Lord, P. van der Harst, D.A. Lawlor, J.S. Sehmi, D.P. Gale, M.N. Wass, K.R. Ahmadi, J. L. Bakker, J. Beckmann, H.J.G. Bilo, M. Bochud, M.J. Brown, M.J. Caulfield, J.M.C. Connell, H.T. Cook, I. Cotlarciuc, G.D. Smith, R. de SilvaG.H. Deng, O. Devuyst, L.D. Dikkeschei, N. Dimkovic, M. Dockrell, A. Dominiczak, S. Ebrahim, T. Eggermann, M. Farrall, L. Ferrucci, J. Floege, N.G. Forouhi, R.T. Gansevoort, X.J. Han, B. Hedblad, J.J.H. van der Heide, B.G. Hepkema, M. Hernandez-Fuentes, E. Hypponen, T. Johnson, P.E. de Jong, N. Kleefstra, V. Lagou, M. Lapsley, Y. Li, R.J.F. Loos, J. Luan, K. Luttropp, C. Marechal, O. Melander, P.B. Munroe, L. Nordfors, A. Parsa, L. Peltonen, B.W.J.H. Penninx, E. Perucha, A. Pouta, I. Prokopenko, P.J. Roderick, A. Ruokonen, N.J. Samani, S. Sanna, M. Schalling, D. Schlessinger, G. Schlieper, M.A.J. Seelen, A.R. Shuldiner, M. Sjogren, J.H. Smit, H. Snieder, N. Soranzo, T.D. Spector, P. Stenvinkel, M.J.E. Sternberg, R. Swaminathan, T. Tanaka, L.J. Ubink-Veltmaat, M. Uda, P. Vollenweider, C. Wallace, D. Waterworth, K. Zerres, G. Waeber, N.J. Wareham, P.H. Maxwell, M.I. McCarthy, M.R. Jarvelin, V. Mooser, G.R. Abecasis, L. Lightstone, J. Scott, G. Navis, P. Elliott, J.S. Kooner, Marketa Sjögren

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234 Citations (Scopus)

Abstract

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease

Original language	English
Pages (from-to)	373-375
Journal	Nature Genetics
Volume	42
Issue number	5
DOIs	https://doi.org/10.1038/ng.566
Publication status	Published - 2010

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Chambers, J. C., Zhang, W. H., Lord, G. M., van der Harst, P., Lawlor, D. A., Sehmi, J. S., Gale, D. P., Wass, M. N., Ahmadi, K. R., Bakker, J. L., Beckmann, J., Bilo, H. J. G., Bochud, M., Brown, M. J., Caulfield, M. J., Connell, J. M. C., Cook, H. T., Cotlarciuc, I., Smith, G. D., ... Sjögren, M. (2010). Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42(5), 373-375. https://doi.org/10.1038/ng.566

@article{c5dedbf4d0c84a539a8db740a5a28514,

title = "Genetic loci influencing kidney function and chronic kidney disease",

abstract = "Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease",

author = "J.C. Chambers and W.H. Zhang and G.M. Lord and {van der Harst}, P. and D.A. Lawlor and J.S. Sehmi and D.P. Gale and M.N. Wass and K.R. Ahmadi and Bakker, {J. L.} and J. Beckmann and H.J.G. Bilo and M. Bochud and M.J. Brown and M.J. Caulfield and J.M.C. Connell and H.T. Cook and I. Cotlarciuc and G.D. Smith and {de Silva}, R. and G.H. Deng and O. Devuyst and L.D. Dikkeschei and N. Dimkovic and M. Dockrell and A. Dominiczak and S. Ebrahim and T. Eggermann and M. Farrall and L. Ferrucci and J. Floege and N.G. Forouhi and R.T. Gansevoort and X.J. Han and B. Hedblad and {van der Heide}, J.J.H. and B.G. Hepkema and M. Hernandez-Fuentes and E. Hypponen and T. Johnson and {de Jong}, P.E. and N. Kleefstra and V. Lagou and M. Lapsley and Y. Li and R.J.F. Loos and J. Luan and K. Luttropp and C. Marechal and O. Melander and P.B. Munroe and L. Nordfors and A. Parsa and L. Peltonen and B.W.J.H. Penninx and E. Perucha and A. Pouta and I. Prokopenko and P.J. Roderick and A. Ruokonen and N.J. Samani and S. Sanna and M. Schalling and D. Schlessinger and G. Schlieper and M.A.J. Seelen and A.R. Shuldiner and M. Sjogren and J.H. Smit and H. Snieder and N. Soranzo and T.D. Spector and P. Stenvinkel and M.J.E. Sternberg and R. Swaminathan and T. Tanaka and L.J. Ubink-Veltmaat and M. Uda and P. Vollenweider and C. Wallace and D. Waterworth and K. Zerres and G. Waeber and N.J. Wareham and P.H. Maxwell and M.I. McCarthy and M.R. Jarvelin and V. Mooser and G.R. Abecasis and L. Lightstone and J. Scott and G. Navis and P. Elliott and J.S. Kooner and Marketa Sj{\"o}gren",

year = "2010",

doi = "https://doi.org/10.1038/ng.566",

language = "English",

volume = "42",

pages = "373--375",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

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Chambers, JC, Zhang, WH, Lord, GM, van der Harst, P, Lawlor, DA, Sehmi, JS, Gale, DP, Wass, MN, Ahmadi, KR, Bakker, JL, Beckmann, J, Bilo, HJG, Bochud, M, Brown, MJ, Caulfield, MJ, Connell, JMC, Cook, HT, Cotlarciuc, I, Smith, GD, de Silva, R, Deng, GH, Devuyst, O, Dikkeschei, LD, Dimkovic, N, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Ferrucci, L, Floege, J, Forouhi, NG, Gansevoort, RT, Han, XJ, Hedblad, B, van der Heide, JJH, Hepkema, BG, Hernandez-Fuentes, M, Hypponen, E, Johnson, T, de Jong, PE, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, RJF, Luan, J, Luttropp, K, Marechal, C, Melander, O, Munroe, PB, Nordfors, L, Parsa, A, Peltonen, L, Penninx, BWJH, Perucha, E, Pouta, A, Prokopenko, I, Roderick, PJ, Ruokonen, A, Samani, NJ, Sanna, S, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, MAJ, Shuldiner, AR, Sjogren, M, Smit, JH, Snieder, H, Soranzo, N, Spector, TD, Stenvinkel, P, Sternberg, MJE, Swaminathan, R, Tanaka, T, Ubink-Veltmaat, LJ, Uda, M, Vollenweider, P, Wallace, C, Waterworth, D, Zerres, K, Waeber, G, Wareham, NJ, Maxwell, PH, McCarthy, MI, Jarvelin, MR, Mooser, V, Abecasis, GR, Lightstone, L, Scott, J, Navis, G, Elliott, P, Kooner, JS & Sjögren, M 2010, 'Genetic loci influencing kidney function and chronic kidney disease', Nature Genetics, vol. 42, no. 5, pp. 373-375. https://doi.org/10.1038/ng.566

TY - JOUR

T1 - Genetic loci influencing kidney function and chronic kidney disease

AU - Chambers, J.C.

AU - Zhang, W.H.

AU - Lord, G.M.

AU - van der Harst, P.

AU - Lawlor, D.A.

AU - Sehmi, J.S.

AU - Gale, D.P.

AU - Wass, M.N.

AU - Ahmadi, K.R.

AU - Bakker, J. L.

AU - Beckmann, J.

AU - Bilo, H.J.G.

AU - Bochud, M.

AU - Brown, M.J.

AU - Caulfield, M.J.

AU - Connell, J.M.C.

AU - Cook, H.T.

AU - Cotlarciuc, I.

AU - Smith, G.D.

AU - de Silva, R.

AU - Deng, G.H.

AU - Devuyst, O.

AU - Dikkeschei, L.D.

AU - Dimkovic, N.

AU - Dockrell, M.

AU - Dominiczak, A.

AU - Ebrahim, S.

AU - Eggermann, T.

AU - Farrall, M.

AU - Ferrucci, L.

AU - Floege, J.

AU - Forouhi, N.G.

AU - Gansevoort, R.T.

AU - Han, X.J.

AU - Hedblad, B.

AU - van der Heide, J.J.H.

AU - Hepkema, B.G.

AU - Hernandez-Fuentes, M.

AU - Hypponen, E.

AU - Johnson, T.

AU - de Jong, P.E.

AU - Kleefstra, N.

AU - Lagou, V.

AU - Lapsley, M.

AU - Li, Y.

AU - Loos, R.J.F.

AU - Luan, J.

AU - Luttropp, K.

AU - Marechal, C.

AU - Melander, O.

AU - Munroe, P.B.

AU - Nordfors, L.

AU - Parsa, A.

AU - Peltonen, L.

AU - Penninx, B.W.J.H.

AU - Perucha, E.

AU - Pouta, A.

AU - Prokopenko, I.

AU - Roderick, P.J.

AU - Ruokonen, A.

AU - Samani, N.J.

AU - Sanna, S.

AU - Schalling, M.

AU - Schlessinger, D.

AU - Schlieper, G.

AU - Seelen, M.A.J.

AU - Shuldiner, A.R.

AU - Sjogren, M.

AU - Smit, J.H.

AU - Snieder, H.

AU - Soranzo, N.

AU - Spector, T.D.

AU - Stenvinkel, P.

AU - Sternberg, M.J.E.

AU - Swaminathan, R.

AU - Tanaka, T.

AU - Ubink-Veltmaat, L.J.

AU - Uda, M.

AU - Vollenweider, P.

AU - Wallace, C.

AU - Waterworth, D.

AU - Zerres, K.

AU - Waeber, G.

AU - Wareham, N.J.

AU - Maxwell, P.H.

AU - McCarthy, M.I.

AU - Jarvelin, M.R.

AU - Mooser, V.

AU - Abecasis, G.R.

AU - Lightstone, L.

AU - Scott, J.

AU - Navis, G.

AU - Elliott, P.

AU - Kooner, J.S.

AU - Sjögren, Marketa

PY - 2010

Y1 - 2010

N2 - Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease

AB - Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease

U2 - https://doi.org/10.1038/ng.566

DO - https://doi.org/10.1038/ng.566

M3 - Article

C2 - 20383145

SN - 1061-4036

VL - 42

SP - 373

EP - 375

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -