TY - JOUR
T1 - Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery
T2 - A systematic review
AU - van der Meer, Rieneke
AU - Mohamed, Siham A.
AU - Monpellier, Valerie M.
AU - Liem, Ronald S. L.
AU - Hazebroek, Eric J.
AU - Franks, Paul W.
AU - Frayling, Timothy M.
AU - Janssen, Ignace M. C.
AU - Serlie, Mireille J.
N1 - Funding Information: The Nederlandse Obesitas Kliniek received funding from Medtronic (salary for PhD student R. van der Meer). Medtronic have no influence on the results or the writing of the manuscript. The other authors declare that they have no conflict of interest. Publisher Copyright: © 2023 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
PY - 2023/12
Y1 - 2023/12
N2 - The extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making. This review evaluates current evidence addressing the association of genetic variants with weight loss and changes in metabolic parameters after bariatric surgery. A search was conducted using Medline, Embase, Scopus, Web of Science, and Cochrane Library. Fifty-two eligible studies were identified. Single nucleotide polymorphisms (SNPs) at ADIPOQ (rs226729, rs1501299, rs3774261, and rs17300539) showed a positive association with postoperative change in measures of glucose homeostasis and lipid profiles (n = 4), but not with weight loss after surgery (n = 6). SNPs at FTO (rs11075986, rs16952482, rs8050136, rs9939609, rs9930506, and rs16945088) (n = 10) and MC4R (rs11152213, rs476828, rs2229616, rs9947255, rs17773430, rs5282087, and rs17782313) (n = 9) were inconsistently associated with weight loss and metabolic improvement. Four studies examining the UCP2 SNP rs660339 reported associations with postsurgical weight loss. In summary, there is limited evidence supporting a role for specific genetic variants in surgical outcomes after bariatric surgery. Most studies have adopted a candidate gene approach, limiting the scope for discovery, suggesting that the absence of compelling evidence is not evidence of absence.
AB - The extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making. This review evaluates current evidence addressing the association of genetic variants with weight loss and changes in metabolic parameters after bariatric surgery. A search was conducted using Medline, Embase, Scopus, Web of Science, and Cochrane Library. Fifty-two eligible studies were identified. Single nucleotide polymorphisms (SNPs) at ADIPOQ (rs226729, rs1501299, rs3774261, and rs17300539) showed a positive association with postoperative change in measures of glucose homeostasis and lipid profiles (n = 4), but not with weight loss after surgery (n = 6). SNPs at FTO (rs11075986, rs16952482, rs8050136, rs9939609, rs9930506, and rs16945088) (n = 10) and MC4R (rs11152213, rs476828, rs2229616, rs9947255, rs17773430, rs5282087, and rs17782313) (n = 9) were inconsistently associated with weight loss and metabolic improvement. Four studies examining the UCP2 SNP rs660339 reported associations with postsurgical weight loss. In summary, there is limited evidence supporting a role for specific genetic variants in surgical outcomes after bariatric surgery. Most studies have adopted a candidate gene approach, limiting the scope for discovery, suggesting that the absence of compelling evidence is not evidence of absence.
KW - SNPs
KW - bariatric surgery
KW - genetic variants
KW - surgery outcomes
UR - http://www.scopus.com/inward/record.url?scp=85168876923&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/obr.13626
DO - https://doi.org/10.1111/obr.13626
M3 - Review article
C2 - 37632325
SN - 1467-7881
VL - 24
JO - Obesity Reviews
JF - Obesity Reviews
IS - 12
M1 - e13626
ER -