TY - JOUR
T1 - Genotype by Environment Interactions in Cognitive Ability: A Survey of 14 Studies from Four Countries Covering Four Age Groups
AU - Molenaar, D.
AU - van der Sluis, S.
AU - Boomsma, D.I.
AU - Haworth, C.M.A.
AU - Hewitt, J.K.
AU - Martin, N.G.
AU - Plomin, R.
AU - Wright, M.J.
AU - Dolan, C.V.
PY - 2013
Y1 - 2013
N2 - A large part of the variation in cognitive ability is known to be due to genetic factors. Researchers have tried to identify modifiers that influence the heritability of cognitive ability, indicating a genotype by environment interaction (G×E). To date, such modifiers include measured variables like income and socioeconomic status. The present paper focuses on G×E in cognitive ability where the environmental variable is an unmeasured environmental factor that is uncorrelated in family members. We examined this type of G×E in the GHCA-database (Haworth et al., Behav Genet 39:359-370, 2009), which comprises data of 14 different cognition studies from four different countries including participants of different ages. Results indicate that for younger participants (4-13 years), the strength of E decreases across the additive genetic factor A, but that this effect reverts for older participants (17-34 years). However, a clear and general conclusion about the presence of a genuine G×E is hampered by differences between the individual studies with respect to environmental and genetic influences on cognitive ability. © 2013 Springer Science+Business Media New York.
AB - A large part of the variation in cognitive ability is known to be due to genetic factors. Researchers have tried to identify modifiers that influence the heritability of cognitive ability, indicating a genotype by environment interaction (G×E). To date, such modifiers include measured variables like income and socioeconomic status. The present paper focuses on G×E in cognitive ability where the environmental variable is an unmeasured environmental factor that is uncorrelated in family members. We examined this type of G×E in the GHCA-database (Haworth et al., Behav Genet 39:359-370, 2009), which comprises data of 14 different cognition studies from four different countries including participants of different ages. Results indicate that for younger participants (4-13 years), the strength of E decreases across the additive genetic factor A, but that this effect reverts for older participants (17-34 years). However, a clear and general conclusion about the presence of a genuine G×E is hampered by differences between the individual studies with respect to environmental and genetic influences on cognitive ability. © 2013 Springer Science+Business Media New York.
U2 - https://doi.org/10.1007/s10519-012-9581-7
DO - https://doi.org/10.1007/s10519-012-9581-7
M3 - Article
C2 - 23397253
SN - 0001-8244
VL - 43
SP - 208
EP - 219
JO - Behavior genetics
JF - Behavior genetics
IS - 3
ER -