Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice

Yasunori Omata; Michael Frech; Tatjana Primbs; S. bastien Lucas; Darja Andreev; Carina Scholtysek; Kerstin Sarter; Markus Kindermann; Nataliya Yeremenko; Dominique L. Baeten; Nico Andreas; Thomas Kamradt; Aline Bozec; Andreas Ramming; Gerhard Krönke; Stefan Wirtz; Georg Schett; Mario M. Zaiss

doi:https://doi.org/10.1016/j.celrep.2018.06.005

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice

Yasunori Omata, Michael Frech, Tatjana Primbs, S. bastien Lucas, Darja Andreev, Carina Scholtysek, Kerstin Sarter, Markus Kindermann, Nataliya Yeremenko, Dominique L. Baeten, Nico Andreas, Thomas Kamradt, Aline Bozec, Andreas Ramming, Gerhard Krönke, Stefan Wirtz, Georg Schett, Mario M. Zaiss

Research output: Contribution to journal › Article › Academic › peer-review

59 Citations (Scopus)

Abstract

Group 2 innate lymphoid cells (ILC2s) were detected in the peripheral blood and the joints of rheumatoid arthritis (RA) patients, serum-induced arthritis (SIA), and collagen-induced arthritis (CIA) using flow cytometry. Circulating ILC2s were significantly increased in RA patients compared with healthy controls and inversely correlated with disease activity. Induction of arthritis in mice led to a fast increase in ILC2 number. To elucidate the role of ILC2 in arthritis, loss- and gain-of-function mouse models for ILC2 were subjected to arthritis. Reduction of ILC2 numbers in RORαcre/GATA3fl/fl and Tie2cre/RORαfl/fl mice significantly exacerbated arthritis. Increasing ILC2 numbers in mice by IL-25/IL-33 mini-circles or IL-2/IL-2 antibody complex and the adoptive transfer of wild-type (WT) ILC2s significantly attenuated arthritis by affecting the initiation phase. In addition, adoptive transfer of IL-4/13-competent WT but not IL-4/13−/− ILC2s and decreased cytokine secretion by macrophages. These data show that ILC2s have immune-regulatory functions in arthritis.

Original language	English
Pages (from-to)	169-180
Journal	Cell reports
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2018.06.005
Publication status	Published - 2018

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Omata, Y., Frech, M., Primbs, T., Lucas, S. B., Andreev, D., Scholtysek, C., Sarter, K., Kindermann, M., Yeremenko, N., Baeten, D. L., Andreas, N., Kamradt, T., Bozec, A., Ramming, A., Krönke, G., Wirtz, S., Schett, G., & Zaiss, M. M. (2018). Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Cell reports, 24(1), 169-180. https://doi.org/10.1016/j.celrep.2018.06.005

@article{072611f2bb1a40dd88a44b31e1c671d1,

title = "Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice",

abstract = "Group 2 innate lymphoid cells (ILC2s) were detected in the peripheral blood and the joints of rheumatoid arthritis (RA) patients, serum-induced arthritis (SIA), and collagen-induced arthritis (CIA) using flow cytometry. Circulating ILC2s were significantly increased in RA patients compared with healthy controls and inversely correlated with disease activity. Induction of arthritis in mice led to a fast increase in ILC2 number. To elucidate the role of ILC2 in arthritis, loss- and gain-of-function mouse models for ILC2 were subjected to arthritis. Reduction of ILC2 numbers in RORαcre/GATA3fl/fl and Tie2cre/RORαfl/fl mice significantly exacerbated arthritis. Increasing ILC2 numbers in mice by IL-25/IL-33 mini-circles or IL-2/IL-2 antibody complex and the adoptive transfer of wild-type (WT) ILC2s significantly attenuated arthritis by affecting the initiation phase. In addition, adoptive transfer of IL-4/13-competent WT but not IL-4/13−/− ILC2s and decreased cytokine secretion by macrophages. These data show that ILC2s have immune-regulatory functions in arthritis.",

author = "Yasunori Omata and Michael Frech and Tatjana Primbs and Lucas, {S. bastien} and Darja Andreev and Carina Scholtysek and Kerstin Sarter and Markus Kindermann and Nataliya Yeremenko and Baeten, {Dominique L.} and Nico Andreas and Thomas Kamradt and Aline Bozec and Andreas Ramming and Gerhard Kr{\"o}nke and Stefan Wirtz and Georg Schett and Zaiss, {Mario M.}",

year = "2018",

doi = "https://doi.org/10.1016/j.celrep.2018.06.005",

language = "English",

volume = "24",

pages = "169--180",

journal = "Cell reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "1",

}

Omata, Y, Frech, M, Primbs, T, Lucas, SB, Andreev, D, Scholtysek, C, Sarter, K, Kindermann, M, Yeremenko, N , Baeten, DL, Andreas, N, Kamradt, T, Bozec, A, Ramming, A, Krönke, G, Wirtz, S, Schett, G & Zaiss, MM 2018, 'Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice', Cell reports, vol. 24, no. 1, pp. 169-180. https://doi.org/10.1016/j.celrep.2018.06.005

TY - JOUR

T1 - Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice

AU - Omata, Yasunori

AU - Frech, Michael

AU - Primbs, Tatjana

AU - Lucas, S. bastien

AU - Andreev, Darja

AU - Scholtysek, Carina

AU - Sarter, Kerstin

AU - Kindermann, Markus

AU - Yeremenko, Nataliya

AU - Baeten, Dominique L.

AU - Andreas, Nico

AU - Kamradt, Thomas

AU - Bozec, Aline

AU - Ramming, Andreas

AU - Krönke, Gerhard

AU - Wirtz, Stefan

AU - Schett, Georg

AU - Zaiss, Mario M.

PY - 2018

Y1 - 2018

N2 - Group 2 innate lymphoid cells (ILC2s) were detected in the peripheral blood and the joints of rheumatoid arthritis (RA) patients, serum-induced arthritis (SIA), and collagen-induced arthritis (CIA) using flow cytometry. Circulating ILC2s were significantly increased in RA patients compared with healthy controls and inversely correlated with disease activity. Induction of arthritis in mice led to a fast increase in ILC2 number. To elucidate the role of ILC2 in arthritis, loss- and gain-of-function mouse models for ILC2 were subjected to arthritis. Reduction of ILC2 numbers in RORαcre/GATA3fl/fl and Tie2cre/RORαfl/fl mice significantly exacerbated arthritis. Increasing ILC2 numbers in mice by IL-25/IL-33 mini-circles or IL-2/IL-2 antibody complex and the adoptive transfer of wild-type (WT) ILC2s significantly attenuated arthritis by affecting the initiation phase. In addition, adoptive transfer of IL-4/13-competent WT but not IL-4/13−/− ILC2s and decreased cytokine secretion by macrophages. These data show that ILC2s have immune-regulatory functions in arthritis.

AB - Group 2 innate lymphoid cells (ILC2s) were detected in the peripheral blood and the joints of rheumatoid arthritis (RA) patients, serum-induced arthritis (SIA), and collagen-induced arthritis (CIA) using flow cytometry. Circulating ILC2s were significantly increased in RA patients compared with healthy controls and inversely correlated with disease activity. Induction of arthritis in mice led to a fast increase in ILC2 number. To elucidate the role of ILC2 in arthritis, loss- and gain-of-function mouse models for ILC2 were subjected to arthritis. Reduction of ILC2 numbers in RORαcre/GATA3fl/fl and Tie2cre/RORαfl/fl mice significantly exacerbated arthritis. Increasing ILC2 numbers in mice by IL-25/IL-33 mini-circles or IL-2/IL-2 antibody complex and the adoptive transfer of wild-type (WT) ILC2s significantly attenuated arthritis by affecting the initiation phase. In addition, adoptive transfer of IL-4/13-competent WT but not IL-4/13−/− ILC2s and decreased cytokine secretion by macrophages. These data show that ILC2s have immune-regulatory functions in arthritis.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049113653&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/29972778

U2 - https://doi.org/10.1016/j.celrep.2018.06.005

DO - https://doi.org/10.1016/j.celrep.2018.06.005

M3 - Article

C2 - 29972778

SN - 2211-1247

VL - 24

SP - 169

EP - 180

JO - Cell reports

JF - Cell reports

IS - 1

ER -

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice

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