GWAS of 126559 Individuals Identifies Genetic Variants Associated with Educational Attainment

C.A. Rietveld; S.E. Medland; J. Derringer; J. Yang; T. Esko; N.W. Martin; H.J. Westra; K. Shakhbazov; A. Abdellaoui; A. Agrawal; E. Albrecht; BZ Alizadeh; N. Amin; J. Barnard; S.E. Baumeister; K.S. Benke; L.F. Bielak; J.A. Boatman; P.A. Boyle; G. Davies; C.A. de Leeuw; N. Eklund; D.S. Evans; R.S. Fehrmann; K. Fischer; C. Gieger; H.K. Gjessing; S. Hägg; J.R. Harris; C. Hayward; C. Holzapfel; C.A. Ibrahim-Verbaas; E. Ingelsson; B. Jacobsson; P.K. Joshi; A. Jugessur; M. Kaakinen; S. Kanoni; J. Karjalainen; I. Kolcic; K. Kristiansson; Z. Kutalik; J. Lahti; S.H. Lee; P. Lin; P.A. Lind; Y. Liu; K. Lohman; M. Loitfelder; G. McMahon; P.M. Vidal; O. Meirelles; L. Milani; R. Myhre; M.L. Nuotio; C.J. Oldmeadow; K.E. Petrovic; W.J. Peyrot; O. Polasek; L. Quaye; E. Reinmaa; J.P. Rice; T.S. Rizzi; H. Schmidt; R. Schmidt; A.V. Smith; J.A. Smith; T. Tanaka; A. Terracciano; M.J. van der Loos; V. Vitart; H. Völzke; J. Wellmann; L. Yu; W. Zhao; J. Allik; J.R. Attia; S. Bandinelli; F. Bastardot; J. Beauchamp; D.A. Bennett; K. Berger; L.J. Bierut; D.I. Boomsma; U. Bültmann; H. Campbell; C.F. Chabris; L. Cherkas; M.K. Chung; F. Cucca; M. de Andrade; P.L. Jager; J.E. de Neve; I.J. Deary; G.V. Dedoussis; P. Deloukas; M. Dimitriou; G. Eiriksdottir; M.F. Elderson; J.G. Eriksson; D.M. Evans; J.D. Faul; L. Ferrucci; M.E. Garcia; H. Grönberg; V. Gudnason; P. Hall; J.M. Harris; T.B. Harris; N.D. Hastie; A.C. Heath; D.G. Hernandez; W. Hoffmann; A. Hofman; R. Holle; E.G. Holliday; J.J. Hottenga; W.G. Iacono; T. Illig; M.R. Järvelin; M. Kähönen; J. Kaprio; R.M. Kirkpatrick; M. Kowgier; A. Latvala; L.J. Launer; D.A. Lawlor; T. Lehtimäki; J. Li; P. Lichtenstein; P. Lichtner; D.C. Liewald; P.A.F. Madden; P.K.E. Magnusson; T.E. Mäkinen; M. Masala; M. McGue; A. Metspalu; A. Mielck; M.B. Miller; G.W. Montgomery; S. Mukherjee; DR Nyholt; B.A. Oostra; L.J. Palmer; A. Palotie; B.W.J.H. Penninx; M. Perola; P.A. Peyser; M. Preisig; K. Räikkönen; O.T. Raitakari; A. Realo; S.M. Ring; S. Ripatti; F. Rivadeneira; I. Rudan; A. Rustichini; V. Salomaa; A.P. Sarin; D. Schlessinger; R.J. Scott; H. Snieder; B. St Pourcain; J.M. Starr; J.H. Sul; I. Surakka; R. Svento; A. Teumer; H. Tiemeier; F.J. van Rooij; D.R. Wagoner; E. Vartiainen; J. Viikari; P. Vollenweider; J.M. Vonk; G. Waeber; D.R. Weir; H.E. Wichmann; E. Widen; G. Willemsen; J.F. Wilson; A.F. Wright; D. Conley; G. Davey Smith; L. Franke; P.J.F. Groenen; M. Johannesson; S. Kardia; R.F. Krueger; D. Laibson; N.G. Martin; M.N. Meyer; D. Posthuma; A.R. Thurik; N.J. Timpson; A.G. Uitterlinden; C.M. van Duijn; P.M. Visscher; D.J. Benjamin; D. Cesarini; P.D. Koellinger; J. Bamard; O. Polašek; J. Welllmann; V. Guðnason; P.M. Kirkpatrick; J.F. Krueger; Behrooz Z. Alizadeh; Rudolf Ferhmann; Vilmundur Guonason

doi:https://doi.org/10.1126/science.1235488

GWAS of 126559 Individuals Identifies Genetic Variants Associated with Educational Attainment

C.A. Rietveld, S.E. Medland, J. Derringer, J. Yang, T. Esko, N.W. Martin, H.J. Westra, K. Shakhbazov, A. Abdellaoui, A. Agrawal, E. Albrecht, BZ Alizadeh, N. Amin, J. Barnard, S.E. Baumeister, K.S. Benke, L.F. Bielak, J.A. Boatman, P.A. Boyle, G. DaviesC.A. de Leeuw, N. Eklund, D.S. Evans, R.S. Fehrmann, K. Fischer, C. Gieger, H.K. Gjessing, S. Hägg, J.R. Harris, C. Hayward, C. Holzapfel, C.A. Ibrahim-Verbaas, E. Ingelsson, B. Jacobsson, P.K. Joshi, A. Jugessur, M. Kaakinen, S. Kanoni, J. Karjalainen, I. Kolcic, K. Kristiansson, Z. Kutalik, J. Lahti, S.H. Lee, P. Lin, P.A. Lind, Y. Liu, K. Lohman, M. Loitfelder, G. McMahon, P.M. Vidal, O. Meirelles, L. Milani, R. Myhre, M.L. Nuotio, C.J. Oldmeadow, K.E. Petrovic, W.J. Peyrot, O. Polasek, L. Quaye, E. Reinmaa, J.P. Rice, T.S. Rizzi, H. Schmidt, R. Schmidt, A.V. Smith, J.A. Smith, T. Tanaka, A. Terracciano, M.J. van der Loos, V. Vitart, H. Völzke, J. Wellmann, L. Yu, W. Zhao, J. Allik, J.R. Attia, S. Bandinelli, F. Bastardot, J. Beauchamp, D.A. Bennett, K. Berger, L.J. Bierut, D.I. Boomsma, U. Bültmann, H. Campbell, C.F. Chabris, L. Cherkas, M.K. Chung, F. Cucca, M. de Andrade, P.L. Jager, J.E. de Neve, I.J. Deary, G.V. Dedoussis, P. Deloukas, M. Dimitriou, G. Eiriksdottir, M.F. Elderson, J.G. Eriksson, D.M. Evans, J.D. Faul, L. Ferrucci, M.E. Garcia, H. Grönberg, V. Gudnason, P. Hall, J.M. Harris, T.B. Harris, N.D. Hastie, A.C. Heath, D.G. Hernandez, W. Hoffmann, A. Hofman, R. Holle, E.G. Holliday, J.J. Hottenga, W.G. Iacono, T. Illig, M.R. Järvelin, M. Kähönen, J. Kaprio, R.M. Kirkpatrick, M. Kowgier, A. Latvala, L.J. Launer, D.A. Lawlor, T. Lehtimäki, J. Li, P. Lichtenstein, P. Lichtner, D.C. Liewald, P.A.F. Madden, P.K.E. Magnusson, T.E. Mäkinen, M. Masala, M. McGue, A. Metspalu, A. Mielck, M.B. Miller, G.W. Montgomery, S. Mukherjee, DR Nyholt, B.A. Oostra, L.J. Palmer, A. Palotie, B.W.J.H. Penninx, M. Perola, P.A. Peyser, M. Preisig, K. Räikkönen, O.T. Raitakari, A. Realo, S.M. Ring, S. Ripatti, F. Rivadeneira, I. Rudan, A. Rustichini, V. Salomaa, A.P. Sarin, D. Schlessinger, R.J. Scott, H. Snieder, B. St Pourcain, J.M. Starr, J.H. Sul, I. Surakka, R. Svento, A. Teumer, H. Tiemeier, F.J. van Rooij, D.R. Wagoner, E. Vartiainen, J. Viikari, P. Vollenweider, J.M. Vonk, G. Waeber, D.R. Weir, H.E. Wichmann, E. Widen, G. Willemsen, J.F. Wilson, A.F. Wright, D. Conley, G. Davey Smith, L. Franke, P.J.F. Groenen, M. Johannesson, S. Kardia, R.F. Krueger, D. Laibson, N.G. Martin, M.N. Meyer, D. Posthuma, A.R. Thurik, N.J. Timpson, A.G. Uitterlinden, C.M. van Duijn, P.M. Visscher, D.J. Benjamin, D. Cesarini, P.D. Koellinger, J. Bamard, O. Polašek, J. Welllmann, V. Guðnason, P.M. Kirkpatrick, J.F. Krueger, Behrooz Z. Alizadeh, Rudolf Ferhmann, Vilmundur Guonason

Research output: Contribution to journal › Article › Academic › peer-review

567 Citations (Scopus)

Abstract

A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R

Original language	English
Pages (from-to)	1467-1471
Journal	Science
Volume	340
Issue number	6139
DOIs	https://doi.org/10.1126/science.1235488
Publication status	Published - 2013

Keywords

Cognition
Educational Status
Endophenotypes
Female
Genetic Loci
Genome-Wide Association Study
Humans
Male
Multifactorial Inheritance
Polymorphism, Single Nucleotide
class eco A

Cohort Studies

Netherlands Twin Register (NTR)

Access to Document

https://doi.org/10.1126/science.1235488

https://pure.uva.nl/ws/files/1550648/141364_410713.pdf

Cite this

Rietveld, C. A., Medland, S. E., Derringer, J., Yang, J., Esko, T., Martin, N. W., Westra, H. J., Shakhbazov, K., Abdellaoui, A., Agrawal, A., Albrecht, E., Alizadeh, BZ., Amin, N., Barnard, J., Baumeister, S. E., Benke, K. S., Bielak, L. F., Boatman, J. A., Boyle, P. A., ... Guonason, V. (2013). GWAS of 126559 Individuals Identifies Genetic Variants Associated with Educational Attainment. Science, 340(6139), 1467-1471. https://doi.org/10.1126/science.1235488

@article{9c0107d1c5c84800b5718aae23f43c03,

title = "GWAS of 126559 Individuals Identifies Genetic Variants Associated with Educational Attainment",

abstract = "A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R",

keywords = "Cognition, Educational Status, Endophenotypes, Female, Genetic Loci, Genome-Wide Association Study, Humans, Male, Multifactorial Inheritance, Polymorphism, Single Nucleotide, class eco A",

author = "C.A. Rietveld and S.E. Medland and J. Derringer and J. Yang and T. Esko and N.W. Martin and H.J. Westra and K. Shakhbazov and A. Abdellaoui and A. Agrawal and E. Albrecht and BZ Alizadeh and N. Amin and J. Barnard and S.E. Baumeister and K.S. Benke and L.F. Bielak and J.A. Boatman and P.A. Boyle and G. Davies and {de Leeuw}, C.A. and N. Eklund and D.S. Evans and R.S. Fehrmann and K. Fischer and C. Gieger and H.K. Gjessing and S. H{\"a}gg and J.R. Harris and C. Hayward and C. Holzapfel and C.A. Ibrahim-Verbaas and E. Ingelsson and B. Jacobsson and P.K. Joshi and A. Jugessur and M. Kaakinen and S. Kanoni and J. Karjalainen and I. Kolcic and K. Kristiansson and Z. Kutalik and J. Lahti and S.H. Lee and P. Lin and P.A. Lind and Y. Liu and K. Lohman and M. Loitfelder and G. McMahon and P.M. Vidal and O. Meirelles and L. Milani and R. Myhre and M.L. Nuotio and C.J. Oldmeadow and K.E. Petrovic and W.J. Peyrot and O. Polasek and L. Quaye and E. Reinmaa and J.P. Rice and T.S. Rizzi and H. Schmidt and R. Schmidt and A.V. Smith and J.A. Smith and T. Tanaka and A. Terracciano and {van der Loos}, M.J. and V. Vitart and H. V{\"o}lzke and J. Wellmann and L. Yu and W. Zhao and J. Allik and J.R. Attia and S. Bandinelli and F. Bastardot and J. Beauchamp and D.A. Bennett and K. Berger and L.J. Bierut and D.I. Boomsma and U. B{\"u}ltmann and H. Campbell and C.F. Chabris and L. Cherkas and M.K. Chung and F. Cucca and {de Andrade}, M. and P.L. Jager and {de Neve}, J.E. and I.J. Deary and G.V. Dedoussis and P. Deloukas and M. Dimitriou and G. Eiriksdottir and M.F. Elderson and J.G. Eriksson and D.M. Evans and J.D. Faul and L. Ferrucci and M.E. Garcia and H. Gr{\"o}nberg and V. Gudnason and P. Hall and J.M. Harris and T.B. Harris and N.D. Hastie and A.C. Heath and D.G. Hernandez and W. Hoffmann and A. Hofman and R. Holle and E.G. Holliday and J.J. Hottenga and W.G. Iacono and T. Illig and M.R. J{\"a}rvelin and M. K{\"a}h{\"o}nen and J. Kaprio and R.M. Kirkpatrick and M. Kowgier and A. Latvala and L.J. Launer and D.A. Lawlor and T. Lehtim{\"a}ki and J. Li and P. Lichtenstein and P. Lichtner and D.C. Liewald and P.A.F. Madden and P.K.E. Magnusson and T.E. M{\"a}kinen and M. Masala and M. McGue and A. Metspalu and A. Mielck and M.B. Miller and G.W. Montgomery and S. Mukherjee and DR Nyholt and B.A. Oostra and L.J. Palmer and A. Palotie and B.W.J.H. Penninx and M. Perola and P.A. Peyser and M. Preisig and K. R{\"a}ikk{\"o}nen and O.T. Raitakari and A. Realo and S.M. Ring and S. Ripatti and F. Rivadeneira and I. Rudan and A. Rustichini and V. Salomaa and A.P. Sarin and D. Schlessinger and R.J. Scott and H. Snieder and {St Pourcain}, B. and J.M. Starr and J.H. Sul and I. Surakka and R. Svento and A. Teumer and H. Tiemeier and {van Rooij}, F.J. and D.R. Wagoner and E. Vartiainen and J. Viikari and P. Vollenweider and J.M. Vonk and G. Waeber and D.R. Weir and H.E. Wichmann and E. Widen and G. Willemsen and J.F. Wilson and A.F. Wright and D. Conley and {Davey Smith}, G. and L. Franke and P.J.F. Groenen and M. Johannesson and S. Kardia and R.F. Krueger and D. Laibson and N.G. Martin and M.N. Meyer and D. Posthuma and A.R. Thurik and N.J. Timpson and A.G. Uitterlinden and {van Duijn}, C.M. and P.M. Visscher and D.J. Benjamin and D. Cesarini and P.D. Koellinger and J. Bamard and O. Pola{\v s}ek and J. Welllmann and V. Gu{\dh}nason and P.M. Kirkpatrick and J.F. Krueger and Alizadeh, {Behrooz Z.} and Rudolf Ferhmann and Vilmundur Guonason",

year = "2013",

doi = "https://doi.org/10.1126/science.1235488",

language = "English",

volume = "340",

pages = "1467--1471",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6139",

}

Rietveld, CA, Medland, SE, Derringer, J, Yang, J, Esko, T, Martin, NW, Westra, HJ, Shakhbazov, K, Abdellaoui, A, Agrawal, A, Albrecht, E, Alizadeh, BZ, Amin, N, Barnard, J, Baumeister, SE, Benke, KS, Bielak, LF, Boatman, JA, Boyle, PA, Davies, G, de Leeuw, CA, Eklund, N, Evans, DS, Fehrmann, RS, Fischer, K, Gieger, C, Gjessing, HK, Hägg, S, Harris, JR, Hayward, C, Holzapfel, C, Ibrahim-Verbaas, CA, Ingelsson, E, Jacobsson, B, Joshi, PK, Jugessur, A, Kaakinen, M, Kanoni, S, Karjalainen, J, Kolcic, I, Kristiansson, K, Kutalik, Z, Lahti, J, Lee, SH, Lin, P, Lind, PA, Liu, Y, Lohman, K, Loitfelder, M, McMahon, G, Vidal, PM, Meirelles, O, Milani, L, Myhre, R, Nuotio, ML, Oldmeadow, CJ, Petrovic, KE, Peyrot, WJ, Polasek, O, Quaye, L, Reinmaa, E, Rice, JP, Rizzi, TS, Schmidt, H, Schmidt, R, Smith, AV, Smith, JA, Tanaka, T, Terracciano, A, van der Loos, MJ, Vitart, V, Völzke, H, Wellmann, J, Yu, L, Zhao, W, Allik, J, Attia, JR, Bandinelli, S, Bastardot, F, Beauchamp, J, Bennett, DA, Berger, K, Bierut, LJ, Boomsma, DI, Bültmann, U, Campbell, H, Chabris, CF, Cherkas, L, Chung, MK, Cucca, F, de Andrade, M, Jager, PL, de Neve, JE, Deary, IJ, Dedoussis, GV, Deloukas, P, Dimitriou, M, Eiriksdottir, G, Elderson, MF, Eriksson, JG, Evans, DM, Faul, JD, Ferrucci, L, Garcia, ME, Grönberg, H, Gudnason, V, Hall, P, Harris, JM, Harris, TB, Hastie, ND, Heath, AC, Hernandez, DG, Hoffmann, W, Hofman, A, Holle, R, Holliday, EG, Hottenga, JJ, Iacono, WG, Illig, T, Järvelin, MR, Kähönen, M, Kaprio, J, Kirkpatrick, RM, Kowgier, M, Latvala, A, Launer, LJ, Lawlor, DA, Lehtimäki, T, Li, J, Lichtenstein, P, Lichtner, P, Liewald, DC, Madden, PAF, Magnusson, PKE, Mäkinen, TE, Masala, M, McGue, M, Metspalu, A, Mielck, A, Miller, MB, Montgomery, GW, Mukherjee, S, Nyholt, DR, Oostra, BA, Palmer, LJ, Palotie, A, Penninx, BWJH, Perola, M, Peyser, PA, Preisig, M, Räikkönen, K, Raitakari, OT, Realo, A, Ring, SM, Ripatti, S, Rivadeneira, F, Rudan, I, Rustichini, A, Salomaa, V, Sarin, AP, Schlessinger, D, Scott, RJ, Snieder, H, St Pourcain, B, Starr, JM, Sul, JH, Surakka, I, Svento, R, Teumer, A, Tiemeier, H, van Rooij, FJ, Wagoner, DR, Vartiainen, E, Viikari, J, Vollenweider, P, Vonk, JM, Waeber, G, Weir, DR, Wichmann, HE, Widen, E, Willemsen, G, Wilson, JF, Wright, AF, Conley, D, Davey Smith, G, Franke, L, Groenen, PJF, Johannesson, M, Kardia, S, Krueger, RF, Laibson, D, Martin, NG, Meyer, MN, Posthuma, D, Thurik, AR, Timpson, NJ, Uitterlinden, AG, van Duijn, CM, Visscher, PM, Benjamin, DJ, Cesarini, D, Koellinger, PD, Bamard, J, Polašek, O, Welllmann, J, Guðnason, V, Kirkpatrick, PM, Krueger, JF, Alizadeh, BZ, Ferhmann, R & Guonason, V 2013, 'GWAS of 126559 Individuals Identifies Genetic Variants Associated with Educational Attainment', Science, vol. 340, no. 6139, pp. 1467-1471. https://doi.org/10.1126/science.1235488

TY - JOUR

T1 - GWAS of 126559 Individuals Identifies Genetic Variants Associated with Educational Attainment

AU - Rietveld, C.A.

AU - Medland, S.E.

AU - Derringer, J.

AU - Yang, J.

AU - Esko, T.

AU - Martin, N.W.

AU - Westra, H.J.

AU - Shakhbazov, K.

AU - Abdellaoui, A.

AU - Agrawal, A.

AU - Albrecht, E.

AU - Alizadeh, BZ

AU - Amin, N.

AU - Barnard, J.

AU - Baumeister, S.E.

AU - Benke, K.S.

AU - Bielak, L.F.

AU - Boatman, J.A.

AU - Boyle, P.A.

AU - Davies, G.

AU - de Leeuw, C.A.

AU - Eklund, N.

AU - Evans, D.S.

AU - Fehrmann, R.S.

AU - Fischer, K.

AU - Gieger, C.

AU - Gjessing, H.K.

AU - Hägg, S.

AU - Harris, J.R.

AU - Hayward, C.

AU - Holzapfel, C.

AU - Ibrahim-Verbaas, C.A.

AU - Ingelsson, E.

AU - Jacobsson, B.

AU - Joshi, P.K.

AU - Jugessur, A.

AU - Kaakinen, M.

AU - Kanoni, S.

AU - Karjalainen, J.

AU - Kolcic, I.

AU - Kristiansson, K.

AU - Kutalik, Z.

AU - Lahti, J.

AU - Lee, S.H.

AU - Lin, P.

AU - Lind, P.A.

AU - Liu, Y.

AU - Lohman, K.

AU - Loitfelder, M.

AU - McMahon, G.

AU - Vidal, P.M.

AU - Meirelles, O.

AU - Milani, L.

AU - Myhre, R.

AU - Nuotio, M.L.

AU - Oldmeadow, C.J.

AU - Petrovic, K.E.

AU - Peyrot, W.J.

AU - Polasek, O.

AU - Quaye, L.

AU - Reinmaa, E.

AU - Rice, J.P.

AU - Rizzi, T.S.

AU - Schmidt, H.

AU - Schmidt, R.

AU - Smith, A.V.

AU - Smith, J.A.

AU - Tanaka, T.

AU - Terracciano, A.

AU - van der Loos, M.J.

AU - Vitart, V.

AU - Völzke, H.

AU - Wellmann, J.

AU - Yu, L.

AU - Zhao, W.

AU - Allik, J.

AU - Attia, J.R.

AU - Bandinelli, S.

AU - Bastardot, F.

AU - Beauchamp, J.

AU - Bennett, D.A.

AU - Berger, K.

AU - Bierut, L.J.

AU - Boomsma, D.I.

AU - Bültmann, U.

AU - Campbell, H.

AU - Chabris, C.F.

AU - Cherkas, L.

AU - Chung, M.K.

AU - Cucca, F.

AU - de Andrade, M.

AU - Jager, P.L.

AU - de Neve, J.E.

AU - Deary, I.J.

AU - Dedoussis, G.V.

AU - Deloukas, P.

AU - Dimitriou, M.

AU - Eiriksdottir, G.

AU - Elderson, M.F.

AU - Eriksson, J.G.

AU - Evans, D.M.

AU - Faul, J.D.

AU - Ferrucci, L.

AU - Garcia, M.E.

AU - Grönberg, H.

AU - Gudnason, V.

AU - Hall, P.

AU - Harris, J.M.

AU - Harris, T.B.

AU - Hastie, N.D.

AU - Heath, A.C.

AU - Hernandez, D.G.

AU - Hoffmann, W.

AU - Hofman, A.

AU - Holle, R.

AU - Holliday, E.G.

AU - Hottenga, J.J.

AU - Iacono, W.G.

AU - Illig, T.

AU - Järvelin, M.R.

AU - Kähönen, M.

AU - Kaprio, J.

AU - Kirkpatrick, R.M.

AU - Kowgier, M.

AU - Latvala, A.

AU - Launer, L.J.

AU - Lawlor, D.A.

AU - Lehtimäki, T.

AU - Li, J.

AU - Lichtenstein, P.

AU - Lichtner, P.

AU - Liewald, D.C.

AU - Madden, P.A.F.

AU - Magnusson, P.K.E.

AU - Mäkinen, T.E.

AU - Masala, M.

AU - McGue, M.

AU - Metspalu, A.

AU - Mielck, A.

AU - Miller, M.B.

AU - Montgomery, G.W.

AU - Mukherjee, S.

AU - Nyholt, DR

AU - Oostra, B.A.

AU - Palmer, L.J.

AU - Palotie, A.

AU - Penninx, B.W.J.H.

AU - Perola, M.

AU - Peyser, P.A.

AU - Preisig, M.

AU - Räikkönen, K.

AU - Raitakari, O.T.

AU - Realo, A.

AU - Ring, S.M.

AU - Ripatti, S.

AU - Rivadeneira, F.

AU - Rudan, I.

AU - Rustichini, A.

AU - Salomaa, V.

AU - Sarin, A.P.

AU - Schlessinger, D.

AU - Scott, R.J.

AU - Snieder, H.

AU - St Pourcain, B.

AU - Starr, J.M.

AU - Sul, J.H.

AU - Surakka, I.

AU - Svento, R.

AU - Teumer, A.

AU - Tiemeier, H.

AU - van Rooij, F.J.

AU - Wagoner, D.R.

AU - Vartiainen, E.

AU - Viikari, J.

AU - Vollenweider, P.

AU - Vonk, J.M.

AU - Waeber, G.

AU - Weir, D.R.

AU - Wichmann, H.E.

AU - Widen, E.

AU - Willemsen, G.

AU - Wilson, J.F.

AU - Wright, A.F.

AU - Conley, D.

AU - Davey Smith, G.

AU - Franke, L.

AU - Groenen, P.J.F.

AU - Johannesson, M.

AU - Kardia, S.

AU - Krueger, R.F.

AU - Laibson, D.

AU - Martin, N.G.

AU - Meyer, M.N.

AU - Posthuma, D.

AU - Thurik, A.R.

AU - Timpson, N.J.

AU - Uitterlinden, A.G.

AU - van Duijn, C.M.

AU - Visscher, P.M.

AU - Benjamin, D.J.

AU - Cesarini, D.

AU - Koellinger, P.D.

AU - Bamard, J.

AU - Polašek, O.

AU - Welllmann, J.

AU - Guðnason, V.

AU - Kirkpatrick, P.M.

AU - Krueger, J.F.

AU - Alizadeh, Behrooz Z.

AU - Ferhmann, Rudolf

AU - Guonason, Vilmundur

PY - 2013

Y1 - 2013

N2 - A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R

AB - A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R

KW - Cognition

KW - Educational Status

KW - Endophenotypes

KW - Female

KW - Genetic Loci

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Multifactorial Inheritance

KW - Polymorphism, Single Nucleotide

KW - class eco A

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879271608&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/23722424

U2 - https://doi.org/10.1126/science.1235488

DO - https://doi.org/10.1126/science.1235488

M3 - Article

C2 - 23722424

SN - 0036-8075

VL - 340

SP - 1467

EP - 1471

JO - Science

JF - Science

IS - 6139

ER -

GWAS of 126559 Individuals Identifies Genetic Variants Associated with Educational Attainment

Abstract

Keywords

Cohort Studies

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