GWAS of 126559 Individuals Identifies Genetic Variants Associated with Educational Attainment

C.A. Rietveld, S.E. Medland, J. Derringer, J. Yang, T. Esko, N.W. Martin, H.J. Westra, K. Shakhbazov, A. Abdellaoui, A. Agrawal, E. Albrecht, BZ Alizadeh, N. Amin, J. Barnard, S.E. Baumeister, K.S. Benke, L.F. Bielak, J.A. Boatman, P.A. Boyle, G. DaviesC.A. de Leeuw, N. Eklund, D.S. Evans, R.S. Fehrmann, K. Fischer, C. Gieger, H.K. Gjessing, S. Hägg, J.R. Harris, C. Hayward, C. Holzapfel, C.A. Ibrahim-Verbaas, E. Ingelsson, B. Jacobsson, P.K. Joshi, A. Jugessur, M. Kaakinen, S. Kanoni, J. Karjalainen, I. Kolcic, K. Kristiansson, Z. Kutalik, J. Lahti, S.H. Lee, P. Lin, P.A. Lind, Y. Liu, K. Lohman, M. Loitfelder, G. McMahon, P.M. Vidal, O. Meirelles, L. Milani, R. Myhre, M.L. Nuotio, C.J. Oldmeadow, K.E. Petrovic, W.J. Peyrot, O. Polasek, L. Quaye, E. Reinmaa, J.P. Rice, T.S. Rizzi, H. Schmidt, R. Schmidt, A.V. Smith, J.A. Smith, T. Tanaka, A. Terracciano, M.J. van der Loos, V. Vitart, H. Völzke, J. Wellmann, L. Yu, W. Zhao, J. Allik, J.R. Attia, S. Bandinelli, F. Bastardot, J. Beauchamp, D.A. Bennett, K. Berger, L.J. Bierut, D.I. Boomsma, U. Bültmann, H. Campbell, C.F. Chabris, L. Cherkas, M.K. Chung, F. Cucca, M. de Andrade, P.L. Jager, J.E. de Neve, I.J. Deary, G.V. Dedoussis, P. Deloukas, M. Dimitriou, G. Eiriksdottir, M.F. Elderson, J.G. Eriksson, D.M. Evans, J.D. Faul, L. Ferrucci, M.E. Garcia, H. Grönberg, V. Gudnason, P. Hall, J.M. Harris, T.B. Harris, N.D. Hastie, A.C. Heath, D.G. Hernandez, W. Hoffmann, A. Hofman, R. Holle, E.G. Holliday, J.J. Hottenga, W.G. Iacono, T. Illig, M.R. Järvelin, M. Kähönen, J. Kaprio, R.M. Kirkpatrick, M. Kowgier, A. Latvala, L.J. Launer, D.A. Lawlor, T. Lehtimäki, J. Li, P. Lichtenstein, P. Lichtner, D.C. Liewald, P.A.F. Madden, P.K.E. Magnusson, T.E. Mäkinen, M. Masala, M. McGue, A. Metspalu, A. Mielck, M.B. Miller, G.W. Montgomery, S. Mukherjee, DR Nyholt, B.A. Oostra, L.J. Palmer, A. Palotie, B.W.J.H. Penninx, M. Perola, P.A. Peyser, M. Preisig, K. Räikkönen, O.T. Raitakari, A. Realo, S.M. Ring, S. Ripatti, F. Rivadeneira, I. Rudan, A. Rustichini, V. Salomaa, A.P. Sarin, D. Schlessinger, R.J. Scott, H. Snieder, B. St Pourcain, J.M. Starr, J.H. Sul, I. Surakka, R. Svento, A. Teumer, H. Tiemeier, F.J. van Rooij, D.R. Wagoner, E. Vartiainen, J. Viikari, P. Vollenweider, J.M. Vonk, G. Waeber, D.R. Weir, H.E. Wichmann, E. Widen, G. Willemsen, J.F. Wilson, A.F. Wright, D. Conley, G. Davey Smith, L. Franke, P.J.F. Groenen, M. Johannesson, S. Kardia, R.F. Krueger, D. Laibson, N.G. Martin, M.N. Meyer, D. Posthuma, A.R. Thurik, N.J. Timpson, A.G. Uitterlinden, C.M. van Duijn, P.M. Visscher, D.J. Benjamin, D. Cesarini, P.D. Koellinger, J. Bamard, O. Polašek, J. Welllmann, V. Guðnason, P.M. Kirkpatrick, J.F. Krueger, Behrooz Z. Alizadeh, Rudolf Ferhmann, Vilmundur Guonason

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Abstract

A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R
Original languageEnglish
Pages (from-to)1467-1471
JournalScience
Volume340
Issue number6139
DOIs
Publication statusPublished - 2013

Keywords

  • Cognition
  • Educational Status
  • Endophenotypes
  • Female
  • Genetic Loci
  • Genome-Wide Association Study
  • Humans
  • Male
  • Multifactorial Inheritance
  • Polymorphism, Single Nucleotide
  • class eco A

Cohort Studies

  • Netherlands Twin Register (NTR)

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