Het belang van intramusculaire vitamine K-toediening bij pasgeborenen

Kevin Berendse; Tim G J de Meij; Joanne Verheij; Sebastiaan W R Nijmeijer; Harriët Heijboer; Vincent G M Geukers

Het belang van intramusculaire vitamine K-toediening bij pasgeborenen

Translated title of the contribution: The importance of administering vitamin K intramuscularly in neonates

Kevin Berendse, Tim G J de Meij, Joanne Verheij, Sebastiaan W R Nijmeijer, Harriët Heijboer, Vincent G M Geukers

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Infants who are born in The Netherlands receive oral vitamin K to prevent bleeding due to a vitamin K deficiency. However the incidence of such bleedings are higher compared to other European countries. Therefore, the Dutch Health Council advised in 2017 to change this guideline from oral to intramuscular administration.

CASE DESCRIPTION: A 2 months old girl presented with a fatal intracranial hemorrhage. A day before she developed a hematoma on her foot and orbit. Despite daily oral vitamin K, blood results revealed a severe vitamin K deficiency-related bleeding. Postmortem liver biopsy and genetic studies showed cholestasis as the most likely cause of malabsorption of fat soluble vitamins due to a heterozygous pathogenic variant in the ABCB11 gene, which could possibly be transient.

CONCLUSION: Our case illustrates the importance of revising the national guideline for vitamin K prophylaxis to intramuscular administration, according to the recommendation of the Dutch Health Council.

Translated title of the contribution	The importance of administering vitamin K intramuscularly in neonates
Original language	Dutch
Article number	D5736
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	165
Issue number	37
Publication status	Published - 26 Jul 2021

Keywords

Cholestasis
Female
Hemorrhage
Humans
Infant
Infant, Newborn
Intracranial Hemorrhages
Vitamin K
Vitamin K Deficiency Bleeding/drug therapy

Cite this

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title = "Het belang van intramusculaire vitamine K-toediening bij pasgeborenen",

abstract = "BACKGROUND: Infants who are born in The Netherlands receive oral vitamin K to prevent bleeding due to a vitamin K deficiency. However the incidence of such bleedings are higher compared to other European countries. Therefore, the Dutch Health Council advised in 2017 to change this guideline from oral to intramuscular administration.CASE DESCRIPTION: A 2 months old girl presented with a fatal intracranial hemorrhage. A day before she developed a hematoma on her foot and orbit. Despite daily oral vitamin K, blood results revealed a severe vitamin K deficiency-related bleeding. Postmortem liver biopsy and genetic studies showed cholestasis as the most likely cause of malabsorption of fat soluble vitamins due to a heterozygous pathogenic variant in the ABCB11 gene, which could possibly be transient.CONCLUSION: Our case illustrates the importance of revising the national guideline for vitamin K prophylaxis to intramuscular administration, according to the recommendation of the Dutch Health Council.",

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AU - de Meij, Tim G J

AU - Verheij, Joanne

AU - Nijmeijer, Sebastiaan W R

AU - Heijboer, Harriët

AU - Geukers, Vincent G M

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2021/7/26

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N2 - BACKGROUND: Infants who are born in The Netherlands receive oral vitamin K to prevent bleeding due to a vitamin K deficiency. However the incidence of such bleedings are higher compared to other European countries. Therefore, the Dutch Health Council advised in 2017 to change this guideline from oral to intramuscular administration.CASE DESCRIPTION: A 2 months old girl presented with a fatal intracranial hemorrhage. A day before she developed a hematoma on her foot and orbit. Despite daily oral vitamin K, blood results revealed a severe vitamin K deficiency-related bleeding. Postmortem liver biopsy and genetic studies showed cholestasis as the most likely cause of malabsorption of fat soluble vitamins due to a heterozygous pathogenic variant in the ABCB11 gene, which could possibly be transient.CONCLUSION: Our case illustrates the importance of revising the national guideline for vitamin K prophylaxis to intramuscular administration, according to the recommendation of the Dutch Health Council.

AB - BACKGROUND: Infants who are born in The Netherlands receive oral vitamin K to prevent bleeding due to a vitamin K deficiency. However the incidence of such bleedings are higher compared to other European countries. Therefore, the Dutch Health Council advised in 2017 to change this guideline from oral to intramuscular administration.CASE DESCRIPTION: A 2 months old girl presented with a fatal intracranial hemorrhage. A day before she developed a hematoma on her foot and orbit. Despite daily oral vitamin K, blood results revealed a severe vitamin K deficiency-related bleeding. Postmortem liver biopsy and genetic studies showed cholestasis as the most likely cause of malabsorption of fat soluble vitamins due to a heterozygous pathogenic variant in the ABCB11 gene, which could possibly be transient.CONCLUSION: Our case illustrates the importance of revising the national guideline for vitamin K prophylaxis to intramuscular administration, according to the recommendation of the Dutch Health Council.

KW - Cholestasis

KW - Female

KW - Hemorrhage

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Intracranial Hemorrhages

KW - Vitamin K

KW - Vitamin K Deficiency Bleeding/drug therapy

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SN - 0028-2162

VL - 165

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

IS - 37

M1 - D5736

ER -

Het belang van intramusculaire vitamine K-toediening bij pasgeborenen

Abstract

Keywords

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