High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4(+) T cells in human melanoma

Carsten Linnemann; Marit M. van Buuren; Laura Bies; Els M. E. Verdegaal; Remko Schotte; Jorg J. A. Calis; Sam Behjati; Arno Velds; Henk Hilkmann; Dris El Atmioui; Marten Visser; Michael R. Stratton; John B. A. G. Haanen; Hergen Spits; Sjoerd H. van der Burg; Ton N. M. Schumacher

doi:https://doi.org/10.1038/nm.3773

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4(+) T cells in human melanoma

Carsten Linnemann, Marit M. van Buuren, Laura Bies, Els M. E. Verdegaal, Remko Schotte, Jorg J. A. Calis, Sam Behjati, Arno Velds, Henk Hilkmann, Dris El Atmioui, Marten Visser, Michael R. Stratton, John B. A. G. Haanen, Hergen Spits, Sjoerd H. van der Burg, Ton N. M. Schumacher

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Abstract

Tumor-specific neo-antigens that arise as a consequence of mutations(1,2) are thought to be important for the therapeutic efficacy of cancer immunotherapies(3-5). Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8(+) T cells(3-7), but it is unclear whether neoantigen-specific CD4(+) T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4(+) T-cell responses in tumor control(8-10), we addressed whether neo-antigen-specific CD4(+) T-cell reactivity is a common property in human melanoma

Original language	English
Pages (from-to)	81-85
Journal	Nature medicine
Volume	21
Issue number	1
DOIs	https://doi.org/10.1038/nm.3773
Publication status	Published - 2015

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https://doi.org/10.1038/nm.3773

Cite this

Linnemann, C., van Buuren, M. M., Bies, L., Verdegaal, E. M. E., Schotte, R., Calis, J. J. A., Behjati, S., Velds, A., Hilkmann, H., Atmioui, D. E., Visser, M., Stratton, M. R., Haanen, J. B. A. G., Spits, H., van der Burg, S. H., & Schumacher, T. N. M. (2015). High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4(+) T cells in human melanoma. Nature medicine, 21(1), 81-85. https://doi.org/10.1038/nm.3773

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title = "High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4(+) T cells in human melanoma",

abstract = "Tumor-specific neo-antigens that arise as a consequence of mutations(1,2) are thought to be important for the therapeutic efficacy of cancer immunotherapies(3-5). Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8(+) T cells(3-7), but it is unclear whether neoantigen-specific CD4(+) T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4(+) T-cell responses in tumor control(8-10), we addressed whether neo-antigen-specific CD4(+) T-cell reactivity is a common property in human melanoma",

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Linnemann, C, van Buuren, MM, Bies, L, Verdegaal, EME, Schotte, R, Calis, JJA, Behjati, S, Velds, A, Hilkmann, H, Atmioui, DE, Visser, M, Stratton, MR, Haanen, JBAG, Spits, H, van der Burg, SH & Schumacher, TNM 2015, 'High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4(+) T cells in human melanoma', Nature medicine, vol. 21, no. 1, pp. 81-85. https://doi.org/10.1038/nm.3773

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AU - Hilkmann, Henk

AU - Atmioui, Dris El

AU - Visser, Marten

AU - Stratton, Michael R.

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AU - Schumacher, Ton N. M.

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