Histone modifications: From genome-wide maps to functional insights

Fred van Leeuwen; Bas van Steensel

doi:https://doi.org/10.1186/gb-2005-6-6-113

Histone modifications: From genome-wide maps to functional insights

Fred van Leeuwen, Bas van Steensel

Research output: Contribution to journal › Article › Academic › peer-review

37 Citations (Scopus)

Abstract

A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward. © 2005 BioMed Central Ltd.

Original language	English
Article number	113
Journal	Genome Biology
Volume	6
Issue number	6
DOIs	https://doi.org/10.1186/gb-2005-6-6-113
Publication status	Published - 2005
Externally published	Yes

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https://doi.org/10.1186/gb-2005-6-6-113

Cite this

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title = "Histone modifications: From genome-wide maps to functional insights",

abstract = "A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward. {\textcopyright} 2005 BioMed Central Ltd.",

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AB - A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward. © 2005 BioMed Central Ltd.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/15960810

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JO - Genome Biology

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Histone modifications: From genome-wide maps to functional insights

Abstract

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