TY - JOUR
T1 - HIV-1 RNAs: sense and antisense, large mRNAs and small siRNAs and miRNAs
AU - Harwig, Alex
AU - Das, Atze T.
AU - Berkhout, Ben
PY - 2015
Y1 - 2015
N2 - Purpose of review This review summarizes recent findings concerning the ever-growing HIV-1 RNA population. Recent findings The retrovirus HIV-1 has an RNA genome that is converted into DNA and is integrated into the genome of the infected host cell. Transcription from the long terminal repeat-encoded promoter results in the production of a full-length genomic RNA and multiple spliced mRNAs. Recent experiments, mainly based on next-generation sequencing, provided evidence for several additional HIV-encoded RNAs, including antisense RNAs and virus-encoded microRNAs. Summary We will survey recent findings related to HIV-1 RNA biosynthesis, especially regulatory mechanisms that control initiation of transcription, capping and polyadenylation. We zoom in on the diversity of HIV-1 derived RNA transcripts, their mode of synthesis and proposed functions in the infected cell. Special attention is paid to the viral transacting responsive RNA hairpin motif that has been suggested to encode microRNAs
AB - Purpose of review This review summarizes recent findings concerning the ever-growing HIV-1 RNA population. Recent findings The retrovirus HIV-1 has an RNA genome that is converted into DNA and is integrated into the genome of the infected host cell. Transcription from the long terminal repeat-encoded promoter results in the production of a full-length genomic RNA and multiple spliced mRNAs. Recent experiments, mainly based on next-generation sequencing, provided evidence for several additional HIV-encoded RNAs, including antisense RNAs and virus-encoded microRNAs. Summary We will survey recent findings related to HIV-1 RNA biosynthesis, especially regulatory mechanisms that control initiation of transcription, capping and polyadenylation. We zoom in on the diversity of HIV-1 derived RNA transcripts, their mode of synthesis and proposed functions in the infected cell. Special attention is paid to the viral transacting responsive RNA hairpin motif that has been suggested to encode microRNAs
U2 - https://doi.org/10.1097/COH.0000000000000135
DO - https://doi.org/10.1097/COH.0000000000000135
M3 - Review article
C2 - 25565176
SN - 1746-630X
VL - 10
SP - 103
EP - 109
JO - Current opinion in HIV and AIDS
JF - Current opinion in HIV and AIDS
IS - 2
ER -