HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

J Ilonen; S Koskinen; S Nejentsev; M Sjöroos; M Knip; E I Schwartz; B Adojaan; L Kovalchuk; A Sochnevs

HLA-DQB10304-DRB10408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

J Ilonen, S Koskinen, S Nejentsev, M Sjöroos, M Knip, E I Schwartz, B Adojaan, L Kovalchuk, A Sochnevs

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

Original language	English
Pages (from-to)	532-4
Number of pages	3
Journal	Tissue Antigens
Volume	49
Issue number	5
Publication status	Published - May 1997
Externally published	Yes

Keywords

Baltic States
Diabetes Mellitus, Type 1/epidemiology
Gene Frequency
HLA-DQ Antigens/genetics
HLA-DQ beta-Chains
Haplotypes
Humans

Cite this

@article{be13ef69827843f784743e0b5cd26f2a,

title = "HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region",

abstract = "The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.",

keywords = "Baltic States, Diabetes Mellitus, Type 1/epidemiology, Gene Frequency, HLA-DQ Antigens/genetics, HLA-DQ beta-Chains, Haplotypes, Humans",

author = "J Ilonen and S Koskinen and S Nejentsev and M Sj{\"o}roos and M Knip and Schwartz, {E I} and B Adojaan and L Kovalchuk and A Sochnevs",

year = "1997",

month = may,

language = "English",

volume = "49",

pages = "532--4",

journal = "Tissue Antigens",

issn = "0001-2815",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

AU - Ilonen, J

AU - Koskinen, S

AU - Nejentsev, S

AU - Sjöroos, M

AU - Knip, M

AU - Schwartz, E I

AU - Adojaan, B

AU - Kovalchuk, L

AU - Sochnevs, A

PY - 1997/5

Y1 - 1997/5

N2 - The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

AB - The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

KW - Baltic States

KW - Diabetes Mellitus, Type 1/epidemiology

KW - Gene Frequency

KW - HLA-DQ Antigens/genetics

KW - HLA-DQ beta-Chains

KW - Haplotypes

KW - Humans

M3 - Article

C2 - 9174152

SN - 0001-2815

VL - 49

SP - 532

EP - 534

JO - Tissue Antigens

JF - Tissue Antigens

IS - 5

ER -