HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

J Ilonen, S Koskinen, S Nejentsev, M Sjöroos, M Knip, E I Schwartz, B Adojaan, L Kovalchuk, A Sochnevs

Research output: Contribution to journalArticleAcademicpeer-review


The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ beta-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

Original languageEnglish
Pages (from-to)532-4
Number of pages3
JournalTissue Antigens
Issue number5
Publication statusPublished - May 1997
Externally publishedYes


  • Baltic States
  • Diabetes Mellitus, Type 1/epidemiology
  • Gene Frequency
  • HLA-DQ Antigens/genetics
  • HLA-DQ beta-Chains
  • Haplotypes
  • Humans

Cite this