HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group

H Reijonen; S Nejentsev; J Tuokko; S Koskinen; E Tuomilehto-Wolf; H K Akerblom; J Ilonen

HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group

H Reijonen, S Nejentsev, J Tuokko, S Koskinen, E Tuomilehto-Wolf, H K Akerblom, J Ilonen

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

Abstract

We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.

Original language	English
Pages (from-to)	357-63
Number of pages	7
Journal	European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics
Volume	24
Issue number	5
Publication status	Published - Oct 1997
Externally published	Yes

Keywords

Adolescent
Alleles
Child
Child, Preschool
Diabetes Mellitus, Type 1/epidemiology
Disease Susceptibility
Finland/epidemiology
Gene Frequency
Genetic Linkage
HLA-B Antigens/analysis
HLA-DQ Antigens/genetics
HLA-DQ beta-Chains
HLA-DR Antigens/analysis
HLA-DR4 Antigen/analysis
HLA-DRB1 Chains
Haplotypes/genetics
Humans
Risk Factors

Cite this

Reijonen, H., Nejentsev, S., Tuokko, J., Koskinen, S., Tuomilehto-Wolf, E., Akerblom, H. K., & Ilonen, J. (1997). HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group. European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics, 24(5), 357-63.

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title = "HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group",

abstract = "We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.",

keywords = "Adolescent, Alleles, Child, Child, Preschool, Diabetes Mellitus, Type 1/epidemiology, Disease Susceptibility, Finland/epidemiology, Gene Frequency, Genetic Linkage, HLA-B Antigens/analysis, HLA-DQ Antigens/genetics, HLA-DQ beta-Chains, HLA-DR Antigens/analysis, HLA-DR4 Antigen/analysis, HLA-DRB1 Chains, Haplotypes/genetics, Humans, Risk Factors",

author = "H Reijonen and S Nejentsev and J Tuokko and S Koskinen and E Tuomilehto-Wolf and Akerblom, {H K} and J Ilonen",

year = "1997",

month = oct,

language = "English",

volume = "24",

pages = "357--63",

journal = "European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics",

issn = "0960-7420",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "5",

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Reijonen, H, Nejentsev, S, Tuokko, J, Koskinen, S, Tuomilehto-Wolf, E, Akerblom, HK & Ilonen, J 1997, 'HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group', European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics, vol. 24, no. 5, pp. 357-63.

HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group. / Reijonen, H; Nejentsev, S; Tuokko, J et al.
In: European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics, Vol. 24, No. 5, 10.1997, p. 357-63.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group

AU - Reijonen, H

AU - Nejentsev, S

AU - Tuokko, J

AU - Koskinen, S

AU - Tuomilehto-Wolf, E

AU - Akerblom, H K

AU - Ilonen, J

PY - 1997/10

Y1 - 1997/10

N2 - We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.

AB - We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.

KW - Adolescent

KW - Alleles

KW - Child

KW - Child, Preschool

KW - Diabetes Mellitus, Type 1/epidemiology

KW - Disease Susceptibility

KW - Finland/epidemiology

KW - Gene Frequency

KW - Genetic Linkage

KW - HLA-B Antigens/analysis

KW - HLA-DQ Antigens/genetics

KW - HLA-DQ beta-Chains

KW - HLA-DR Antigens/analysis

KW - HLA-DR4 Antigen/analysis

KW - HLA-DRB1 Chains

KW - Haplotypes/genetics

KW - Humans

KW - Risk Factors

M3 - Article

C2 - 9442803

SN - 0960-7420

VL - 24

SP - 357

EP - 363

JO - European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics

JF - European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics

IS - 5

ER -