HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group

H Reijonen, S Nejentsev, J Tuokko, S Koskinen, E Tuomilehto-Wolf, H K Akerblom, J Ilonen

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7 Citations (Scopus)


We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.

Original languageEnglish
Pages (from-to)357-63
Number of pages7
JournalEuropean journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics
Issue number5
Publication statusPublished - Oct 1997
Externally publishedYes


  • Adolescent
  • Alleles
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1/epidemiology
  • Disease Susceptibility
  • Finland/epidemiology
  • Gene Frequency
  • Genetic Linkage
  • HLA-B Antigens/analysis
  • HLA-DQ Antigens/genetics
  • HLA-DQ beta-Chains
  • HLA-DR Antigens/analysis
  • HLA-DR4 Antigen/analysis
  • HLA-DRB1 Chains
  • Haplotypes/genetics
  • Humans
  • Risk Factors

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