TY - JOUR
T1 - Human CD8(+) T-cell differentiation in response to viruses
AU - van Lier, René A. W.
AU - ten Berge, Ineke J. M.
AU - Gamadia, Laila E.
PY - 2003
Y1 - 2003
N2 - CD8(+) T cells are essential in the defence against viruses. Recently, peptide-HLA class I tetramers have been used to study immune responses to viruses in humans. This approach has indicated consecutive stages of human CD8(+) T-cell development in acute viral infection and has illustrated the heterogeneity of CD8(+) T cells that are specific for latent viruses. Here, we summarize these findings and discuss their significance for our understanding of antigen-induced CD8(+) T-cell maturation in humans
AB - CD8(+) T cells are essential in the defence against viruses. Recently, peptide-HLA class I tetramers have been used to study immune responses to viruses in humans. This approach has indicated consecutive stages of human CD8(+) T-cell development in acute viral infection and has illustrated the heterogeneity of CD8(+) T cells that are specific for latent viruses. Here, we summarize these findings and discuss their significance for our understanding of antigen-induced CD8(+) T-cell maturation in humans
U2 - https://doi.org/10.1038/nri1254
DO - https://doi.org/10.1038/nri1254
M3 - Review article
C2 - 14647475
SN - 1474-1733
VL - 3
SP - 931
EP - 939
JO - Nature Reviews. Immunology
JF - Nature Reviews. Immunology
IS - 12
ER -