Human CD8(+) T-cell differentiation in response to viruses

René A. W. van Lier, Ineke J. M. ten Berge, Laila E. Gamadia

Research output: Contribution to journalReview articleAcademicpeer-review

263 Citations (Scopus)

Abstract

CD8(+) T cells are essential in the defence against viruses. Recently, peptide-HLA class I tetramers have been used to study immune responses to viruses in humans. This approach has indicated consecutive stages of human CD8(+) T-cell development in acute viral infection and has illustrated the heterogeneity of CD8(+) T cells that are specific for latent viruses. Here, we summarize these findings and discuss their significance for our understanding of antigen-induced CD8(+) T-cell maturation in humans
Original languageEnglish
Pages (from-to)931-939
JournalNature Reviews. Immunology
Volume3
Issue number12
DOIs
Publication statusPublished - 2003

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