Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice

Ingrid Stroo; Jack Yang; Adam A. Anas; J. Daan de Boer; Gerard van Mierlo; Dorina Roem; Diana Wouters; Ruchira Engel; Joris J. T. H. Roelofs; Cornelis van 't Veer; Tom van der Poll; Sacha Zeerleder

doi:https://doi.org/10.1371/journal.pone.0186652

Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice

Ingrid Stroo, Jack Yang, Adam A. Anas, J. Daan de Boer, Gerard van Mierlo, Dorina Roem, Diana Wouters, Ruchira Engel, Joris J. T. H. Roelofs, Cornelis van 't Veer, Tom van der Poll, Sacha Zeerleder

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

C1 esterase inhibitor (C1-INH) can inhibit multiple pathways (complement, contact-kinin, coagulation, and fibrinolysis) that are all implicated in the pathophysiology of asthma. We explored the effect of human plasma-derived C1-INH on allergic lung inflammation in a house dust mite (HDM) induced asthma mouse model by daily administration of C1-INH (15 U) during the challenge phase. NaCl and HDM exposed mice had comparable plasma C1-INH levels, while bronchoalveolar lavage fluid (BALF) levels were increased in HDM exposed mice coinciding with slightly reduced activation of complement (C5a). C1-INH treatment reduced Th2 response and enhanced HDM-specific IgG1. Influx of eosinophils in BALF or lung, pulmonary damage, mucus production, procoagulant response or plasma leakage in BALF was similar in both groups. In conclusion, C1-INH dampens Th2 responses during HDM induced allergic lung inflammation

Original language	English
Pages (from-to)	e0186652
Journal	PLOS ONE
Volume	12
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0186652
Publication status	Published - 2017

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https://doi.org/10.1371/journal.pone.0186652

Cite this

Stroo, I., Yang, J., Anas, A. A., de Boer, J. D., van Mierlo, G., Roem, D., Wouters, D., Engel, R., Roelofs, J. J. T. H., van 't Veer, C., van der Poll, T., & Zeerleder, S. (2017). Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice. PLOS ONE, 12(10), e0186652. https://doi.org/10.1371/journal.pone.0186652

@article{20b1039fba4b4ad581d093b989644b76,

title = "Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice",

abstract = "C1 esterase inhibitor (C1-INH) can inhibit multiple pathways (complement, contact-kinin, coagulation, and fibrinolysis) that are all implicated in the pathophysiology of asthma. We explored the effect of human plasma-derived C1-INH on allergic lung inflammation in a house dust mite (HDM) induced asthma mouse model by daily administration of C1-INH (15 U) during the challenge phase. NaCl and HDM exposed mice had comparable plasma C1-INH levels, while bronchoalveolar lavage fluid (BALF) levels were increased in HDM exposed mice coinciding with slightly reduced activation of complement (C5a). C1-INH treatment reduced Th2 response and enhanced HDM-specific IgG1. Influx of eosinophils in BALF or lung, pulmonary damage, mucus production, procoagulant response or plasma leakage in BALF was similar in both groups. In conclusion, C1-INH dampens Th2 responses during HDM induced allergic lung inflammation",

author = "Ingrid Stroo and Jack Yang and Anas, {Adam A.} and {de Boer}, {J. Daan} and {van Mierlo}, Gerard and Dorina Roem and Diana Wouters and Ruchira Engel and Roelofs, {Joris J. T. H.} and {van 't Veer}, Cornelis and {van der Poll}, Tom and Sacha Zeerleder",

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Stroo, I, Yang, J, Anas, AA, de Boer, JD, van Mierlo, G, Roem, D, Wouters, D, Engel, R, Roelofs, JJTH , van 't Veer, C , van der Poll, T & Zeerleder, S 2017, 'Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice', PLOS ONE, vol. 12, no. 10, pp. e0186652. https://doi.org/10.1371/journal.pone.0186652

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T1 - Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice

AU - Stroo, Ingrid

AU - Yang, Jack

AU - Anas, Adam A.

AU - de Boer, J. Daan

AU - van Mierlo, Gerard

AU - Roem, Dorina

AU - Wouters, Diana

AU - Engel, Ruchira

AU - Roelofs, Joris J. T. H.

AU - van 't Veer, Cornelis

AU - van der Poll, Tom

AU - Zeerleder, Sacha

PY - 2017

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AB - C1 esterase inhibitor (C1-INH) can inhibit multiple pathways (complement, contact-kinin, coagulation, and fibrinolysis) that are all implicated in the pathophysiology of asthma. We explored the effect of human plasma-derived C1-INH on allergic lung inflammation in a house dust mite (HDM) induced asthma mouse model by daily administration of C1-INH (15 U) during the challenge phase. NaCl and HDM exposed mice had comparable plasma C1-INH levels, while bronchoalveolar lavage fluid (BALF) levels were increased in HDM exposed mice coinciding with slightly reduced activation of complement (C5a). C1-INH treatment reduced Th2 response and enhanced HDM-specific IgG1. Influx of eosinophils in BALF or lung, pulmonary damage, mucus production, procoagulant response or plasma leakage in BALF was similar in both groups. In conclusion, C1-INH dampens Th2 responses during HDM induced allergic lung inflammation

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DO - https://doi.org/10.1371/journal.pone.0186652

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