TY - JOUR
T1 - Identification and validation of a 3-gene methylation classifier for HPV-based cervical screening on self-samples
AU - Verlaat, Wina
AU - Snoek, Barbara C
AU - Heideman, Daniëlle A.M.
AU - Wilting, Saskia M
AU - Snijders, Peter J.F.
AU - Novianti, Putri W.
AU - van Splunter, Annina P.
AU - Peeters, Carel F.W.
AU - van Trommel, Nienke E
AU - Massuger, Leon F.A.G.
AU - Bekkers, Ruud L.M.
AU - Melchers, Willem JG
AU - van Kemenade, Folkert J.
AU - Berkhof, Johannes
AU - van de Wiel, Mark A.
AU - Meijer, Chris J.L.M.
AU - Steenbergen, Renske D.M.
PY - 2018/4/9
Y1 - 2018/4/9
N2 - Offering self-sampling of cervico-vaginal material for high-risk human papillomavirus (hrHPV) testing is an effective method to increase the coverage in cervical screening programs. Molecular triage directly on hrHPV-positive self-samples for colposcopy referral opens the way to full molecular cervical screening. Here, we set out to identify a DNA methylation classifier for detection of cervical precancer (CIN3) and cancer, applicable to lavage and brush self-samples.
AB - Offering self-sampling of cervico-vaginal material for high-risk human papillomavirus (hrHPV) testing is an effective method to increase the coverage in cervical screening programs. Molecular triage directly on hrHPV-positive self-samples for colposcopy referral opens the way to full molecular cervical screening. Here, we set out to identify a DNA methylation classifier for detection of cervical precancer (CIN3) and cancer, applicable to lavage and brush self-samples.
U2 - https://doi.org/10.1158/1078-0432.CCR-17-3615
DO - https://doi.org/10.1158/1078-0432.CCR-17-3615
M3 - Article
C2 - 29632006
SN - 1078-0432
SP - clincanres.3615.2017
JO - Clinical Cancer Research
JF - Clinical Cancer Research
ER -