TY - JOUR
T1 - Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70
AU - Lens, S. M.
AU - Keehnen, R. M.
AU - van Oers, M. H.
AU - van Lier, R. A.
AU - Pals, S. T.
AU - Koopman, G.
PY - 1996
Y1 - 1996
N2 - CD27, which belongs to the tumor necrosis factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsils, CD70 is only expressed on part of the IgD-, CD38- B cell population, which have been described as memory B cells. However, in 10% of the tonsils tested, CD70+ IgD+ GC were found. The CD70+ GC B cells were small cells that also expressed CD44 and CD39, but were CD10- and CD38-, suggesting that they represent very recent immigrants that are in the process of forming a GC. The concordant expression of CD27 and its ligand CD70 on this primordial subset of GC B cells suggests an important role for CD27/CD70 interaction at this stage of GC formation
AB - CD27, which belongs to the tumor necrosis factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsils, CD70 is only expressed on part of the IgD-, CD38- B cell population, which have been described as memory B cells. However, in 10% of the tonsils tested, CD70+ IgD+ GC were found. The CD70+ GC B cells were small cells that also expressed CD44 and CD39, but were CD10- and CD38-, suggesting that they represent very recent immigrants that are in the process of forming a GC. The concordant expression of CD27 and its ligand CD70 on this primordial subset of GC B cells suggests an important role for CD27/CD70 interaction at this stage of GC formation
U2 - https://doi.org/10.1002/eji.1830260508
DO - https://doi.org/10.1002/eji.1830260508
M3 - Article
C2 - 8647160
SN - 0014-2980
VL - 26
SP - 1007
EP - 1011
JO - European journal of immunology
JF - European journal of immunology
IS - 5
ER -