TY - JOUR
T1 - Idiopathic pulmonary arterial hypertension in Dutch Caucasian patients is not associated with human herpes virus-8 infection
AU - Bresser, Paul
AU - Cornelissen, Marion I.
AU - van der Bij, Wim
AU - van Noesel, Carel J. M.
AU - Timens, Wim
PY - 2007
Y1 - 2007
N2 - Samples of lung tissue, taken at time of lung transplant, from 13 Dutch Caucasian patients with idiopathic pulmonary arterial hypertension (iPAH) and 14 patients with non-idiopathic PAH were studied for the presence of human herpes virus-8 (HHV-8). By immunohistochemical staining, in none of patients expression of HHV-8 latency-associated nuclear antigen 1 (LANA-1) was demonstrated. Using two nested polymerase chain reactions (PCR) to amplify part of the open reading frame (ORF) 65 and ORF 73, we failed to detect HHV-8 DNA in all samples studied. These results argue strongly against a role for HHV-8 in the pathogenesis of iPAH
AB - Samples of lung tissue, taken at time of lung transplant, from 13 Dutch Caucasian patients with idiopathic pulmonary arterial hypertension (iPAH) and 14 patients with non-idiopathic PAH were studied for the presence of human herpes virus-8 (HHV-8). By immunohistochemical staining, in none of patients expression of HHV-8 latency-associated nuclear antigen 1 (LANA-1) was demonstrated. Using two nested polymerase chain reactions (PCR) to amplify part of the open reading frame (ORF) 65 and ORF 73, we failed to detect HHV-8 DNA in all samples studied. These results argue strongly against a role for HHV-8 in the pathogenesis of iPAH
U2 - https://doi.org/10.1016/j.rmed.2006.08.015
DO - https://doi.org/10.1016/j.rmed.2006.08.015
M3 - Article
C2 - 17011770
SN - 0954-6111
VL - 101
SP - 854
EP - 856
JO - Respiratory medicine
JF - Respiratory medicine
IS - 4
ER -