Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography

Bieneke Janssen; Danielle J. Vugts; Uta Funke; Ger T. Molenaar; Perry S. Kruijer; Bart N. M. van Berckel; Adriaan A. Lammertsma; Albert D. Windhorst

doi:https://doi.org/10.1016/j.bbadis.2015.11.011

Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography

Bieneke Janssen, Danielle J. Vugts, Uta Funke, Ger T. Molenaar, Perry S. Kruijer, Bart N. M. van Berckel, Adriaan A. Lammertsma, Albert D. Windhorst

Research output: Contribution to journal › Article › Academic › peer-review

65 Citations (Scopus)

Abstract

Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain, including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is characterised predominantly by microglial activation, which can be visualised using positron emission tomography (PET). Traditionally, translocator protein 18 kDa (TSPO) is the target for imaging of neuroinflammation using PET. In this review, recent preclinical and clinical research using PET in Alzheimer's disease, multiple sclerosis and stroke is summarised. In addition, new molecular targets for imaging of neuroinflammation, such as monoamine oxidases, adenosine receptors and cannabinoid receptor type 2, are discussed.

Original language	English
Pages (from-to)	425-441
Journal	Biochimica et Biophysica Acta. Molecular Basis of Disease
Volume	1862
Issue number	3
DOIs	https://doi.org/10.1016/j.bbadis.2015.11.011
Publication status	Published - Mar 2016

Keywords

Alzheimer's disease
Microglia
Multiple sclerosis
Neuroinflammation
Positron emission tomography
Stroke

Access to Document

https://doi.org/10.1016/j.bbadis.2015.11.011

Cite this

Janssen, B., Vugts, D. J., Funke, U., Molenaar, G. T., Kruijer, P. S., van Berckel, B. N. M., Lammertsma, A. A., & Windhorst, A. D. (2016). Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1862(3), 425-441. https://doi.org/10.1016/j.bbadis.2015.11.011

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abstract = "Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain, including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is characterised predominantly by microglial activation, which can be visualised using positron emission tomography (PET). Traditionally, translocator protein 18 kDa (TSPO) is the target for imaging of neuroinflammation using PET. In this review, recent preclinical and clinical research using PET in Alzheimer's disease, multiple sclerosis and stroke is summarised. In addition, new molecular targets for imaging of neuroinflammation, such as monoamine oxidases, adenosine receptors and cannabinoid receptor type 2, are discussed.",

keywords = "Alzheimer's disease, Microglia, Multiple sclerosis, Neuroinflammation, Positron emission tomography, Stroke",

author = "Bieneke Janssen and Vugts, {Danielle J.} and Uta Funke and Molenaar, {Ger T.} and Kruijer, {Perry S.} and {van Berckel}, {Bart N. M.} and Lammertsma, {Adriaan A.} and Windhorst, {Albert D.}",

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Janssen, B , Vugts, DJ, Funke, U, Molenaar, GT, Kruijer, PS, van Berckel, BNM , Lammertsma, AA & Windhorst, AD 2016, 'Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography', Biochimica et Biophysica Acta. Molecular Basis of Disease, vol. 1862, no. 3, pp. 425-441. https://doi.org/10.1016/j.bbadis.2015.11.011

Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography. / Janssen, Bieneke ; Vugts, Danielle J.; Funke, Uta et al.
In: Biochimica et Biophysica Acta. Molecular Basis of Disease, Vol. 1862, No. 3, 03.2016, p. 425-441.

Research output: Contribution to journal › Article › Academic › peer-review

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