Abstract
Background: The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. Methods: Anonymized data from an international collaboration were analysed. Criteria for inclusion were patients younger than 50 years diagnosed with stage I-III colonic cancer that was surgically resected. Clinicopathological features, microsatellite status, and disease-specific outcomes were evaluated. Results: A total of 650 patients fulfilled the criteria for inclusion. Microsatellite instability (MSI) was identified in 170 (26.2 per cent), whereas 480 had microsatellite-stable (MSS) tumours (relative risk of MSI 2.5 compared with older patients). MSI was associated with a family history of colorectal cancer and lesions in the proximal colon. The proportions with pathological node-positive disease (45.9 versus 45.6 per cent; P = 1.000) and tumour budding (20.3 versus 20.5 per cent; P = 1.000) were similar in the two groups. Patients with MSI tumours were more likely to have BRAF (22.5 versus 6.9 per cent; P < 0.001) and KRAS (40.0 versus 24.2 per cent; P = 0.006) mutations, and a hereditary cancer syndrome (30.0 versus 5.0 per cent; P < 0.001; relative risk 6). Five-year disease-free survival rates in the MSI group were 95.0, 92.0, and 80.0 per cent for patients with stage I, II, and III tumours, compared with 88.0, 88.0, and 65.0 per cent in the MSS group (P = 0.753, P = 0.487, and P = 0.105 respectively). Conclusion: Patients with early-onset colonic cancer have a high risk of MSI and defined genetic conditions. Those with MSI tumours have more adverse pathology (budding, KRAS/BRAF mutations, and nodal metastases) than older patients with MSI cancers.
Original language | English |
---|---|
Pages (from-to) | 632-636 |
Number of pages | 5 |
Journal | British Journal of Surgery |
Volume | 109 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Jul 2022 |
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In: British Journal of Surgery, Vol. 109, No. 7, 01.07.2022, p. 632-636.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Impact of microsatellite status in early-onset colonic cancer
AU - Zaborowski, Alexandra M.
AU - Adamina, Ahmed Abdile. Michel
AU - Aigner, Felix
AU - D'Allens, Laura
AU - Allmer, Caterina
AU - Álvarez, Andrea
AU - Anula, Rocio
AU - Andric, Mihailo
AU - Bach, Sam Atallah Simon
AU - Bala, Miklosh
AU - Barussaud, Marie
AU - Bausys, Augustinas
AU - Beggs, Andrew
AU - Bellolio, Felipe
AU - Bennett, Melissa-Rose
AU - Berdinskikh, Anton
AU - Bevan, Vicki
AU - Biondo, Sebastiano
AU - Bislenghi, Gabriele
AU - Bludau, Marc
AU - Brouwer, Nelleke
AU - Brown, Carl
AU - Bruns, Christiane
AU - Buchanan, Daniel D.
AU - Buchwald, Pamela
AU - Burger, Jacobus W. A.
AU - Burlov, Nikita
AU - Campanelli, Michela
AU - Capdepont, Maylis
AU - Carvello, Michele
AU - Chew, Hwee-Hoon
AU - Christoforidis, Dimitri
AU - Clark, David
AU - Climent, Marta
AU - Collinson, Rowan
AU - Cologne, Kyle G.
AU - Contreras, Tomas
AU - Croner, Roland
AU - Daniels, Ian R.
AU - Dapri, Giovanni
AU - Davies, Justin
AU - Delrio, Paolo
AU - Denost, Quentin
AU - Deutsch, Michael
AU - Dias, Andre
AU - D'Hoore, Andre
AU - Drozdov, Evgeniy
AU - Duek, Daniel
AU - Dunlop, Malcolm
AU - Dziki, Adam
AU - Edmundson, Aleksandra
AU - Efetov, Sergey
AU - el-Hussuna, Alaa
AU - Elliot, Brodie
AU - Emile, Sameh
AU - Espin, Eloy
AU - Evans, Martyn
AU - Faes, Seraina
AU - Faiz, Omar
AU - Figueiredo, Nuno
AU - Fleming, Fergal
AU - Foppa, Caterina
AU - Fowler, George
AU - Frasson, Matteo
AU - Forgan, Tim
AU - Frizelle, Frank
AU - Gadaev, Shamil
AU - Gellona, Jose
AU - Glyn, Tamara
AU - Goran, Barisic
AU - Greenwood, Emma
AU - Guren, Marianne G.
AU - Guillon, Stephanie
AU - Gutlic, Ida
AU - Hahnloser, Dieter
AU - Hampel, Heather
AU - Hanly, Ann
AU - Hasegawa, Hirotoshi
AU - Iversen, Lene Hjerrild
AU - Hill, Andrew
AU - Hill, James
AU - Hoch, Jiri
AU - Hompes, Roel
AU - Hurtado, Luis
AU - Iaquinandi, Fabiano
AU - Imbrasaite, Ugne
AU - Islam, Rumana
AU - Jafari, Mehrenah D.
AU - Salido, Andrea Jimenez
AU - Jimenez-Toscano, Marta
AU - Kanemitsu, Yukihide
AU - Karachun, Aleksei
AU - Karimuddin, Ahmer A.
AU - Keller, Deborah S.
AU - Kelly, Justin
AU - Kennelly, Rory
AU - Khrykov, Gleb
AU - Kocian, Peter
AU - Koh, Cherry
AU - Kok, Neils
AU - Knight, Katrina A.
AU - Knol, Joep
AU - Kontovounisios, Christos
AU - Korner, Hartwig
AU - Krivokapic, Zoran
AU - Kronberger, Irmgard
AU - Kroon, Hidde Maarten
AU - Kryzauskas, Marius
AU - Kural, Said
AU - Kusters, Miranda
AU - Lakkis, Zaher
AU - Lankov, Timur
AU - Larson, David
AU - Lázár, György
AU - Lee, Kai-Yin
AU - Lee, Suk Hwan
AU - Lefèvre, Jeremie H.
AU - Lepisto, Anna
AU - Lieu, Christopher
AU - Loi, Lynette
AU - Lynch, Craig
AU - Maillou-Martinaud, Helene
AU - Maroli, Annalisa
AU - Martin, Sean
AU - Martling, Anna
AU - Matzel, Klaus E.
AU - Mayol, Julio
AU - McDermott, Frank
AU - Meurette, Guillaume
AU - Millan, Monica
AU - Mitteregger, Martin
AU - Moiseenko, Andrei
AU - Monson, John Rt.
AU - Morarasu, Stefan
AU - Moritani, Konosuke
AU - Möslein, Gabriela
AU - Munini, Martino
AU - Nahas, Caio
AU - Nahas, Sergio
AU - Negoi, Ionut
AU - Novikova, Anastasia
AU - Ocares, Misael
AU - Okabayashi, Koji
AU - Olkina, Alexandra
AU - Oñate-Ocaña, Luis
AU - Otero, Jaime
AU - Ozen, Cihan
AU - Pace, Ugo
AU - Julião, Guilherme Pagin S. o
AU - Panaiotti, Lidiia
AU - Panis, Yves
AU - Papamichael, Demetris
AU - Patel, Swati
AU - Uriburu, Juan Carlos Patrón
AU - Peng, Sze-Lin
AU - Pera, Miguel
AU - Perez, Rodrigo O.
AU - Petrov, Alexei
AU - Pfeffer, Frank
AU - Phang, Terry P.
AU - Poskus, Tomas
AU - Pringle, Heather
AU - Proud, David
AU - Raguz, Ivana
AU - Rama, Nuno
AU - Rasheed, Shahnawaz
AU - Raval, Manoj J.
AU - Rega, Daniela
AU - Reissfelder, Christoph
AU - Meneses, Juan Carlos Reyes
AU - Ris, Frederic
AU - Riss, Stefan
AU - Rodriguez-Zentner, Homero
AU - Roxburgh, Campbell S.
AU - Saklani, Avanish
AU - Sammour, Tarik
AU - Saraste, Deborah
AU - Schneider, Martin
AU - Seishima, Ryo
AU - Sekulic, Aleksandar
AU - Seppala, Toni
AU - Sheahan, Kieran
AU - Shlomina, Alexandra
AU - Sigismondo, Guiseppe
AU - Singnomklao, Tongplaew
AU - Siragusa, Leandro
AU - Smart, Neil
AU - Solis-Peña, Alejandro
AU - Spinelli, Antonino
AU - Staiger, Roxane D.
AU - Stamos, Michael J.
AU - Steele, Scott
AU - Tan, Ker-Kan
AU - Tanis, Pieter J.
AU - Tekkis, Paris
AU - Teklay, Biniam
AU - Tengku, Sabrina
AU - Tsarkov, Petr
AU - Turina, Matthias
AU - Ulrich, Alexis
AU - Vailati, Bruna B.
AU - van Harten, Meike
AU - Verhoef, Cornelis
AU - Warrier, Satish
AU - Wexner, Steven
AU - de Wilt, Hans
AU - Weinberg, Benjamin A.
AU - Wells, Cameron
AU - Wolthuis, Albert
AU - Xynos, Evangelos
AU - You, Nancy
AU - Zakharenko, Alexander
AU - Zeballos, Justino
AU - Zhou, Jonathan
AU - Winter, Des C.
N1 - Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of BJS Society Ltd. All rights reserved.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Background: The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. Methods: Anonymized data from an international collaboration were analysed. Criteria for inclusion were patients younger than 50 years diagnosed with stage I-III colonic cancer that was surgically resected. Clinicopathological features, microsatellite status, and disease-specific outcomes were evaluated. Results: A total of 650 patients fulfilled the criteria for inclusion. Microsatellite instability (MSI) was identified in 170 (26.2 per cent), whereas 480 had microsatellite-stable (MSS) tumours (relative risk of MSI 2.5 compared with older patients). MSI was associated with a family history of colorectal cancer and lesions in the proximal colon. The proportions with pathological node-positive disease (45.9 versus 45.6 per cent; P = 1.000) and tumour budding (20.3 versus 20.5 per cent; P = 1.000) were similar in the two groups. Patients with MSI tumours were more likely to have BRAF (22.5 versus 6.9 per cent; P < 0.001) and KRAS (40.0 versus 24.2 per cent; P = 0.006) mutations, and a hereditary cancer syndrome (30.0 versus 5.0 per cent; P < 0.001; relative risk 6). Five-year disease-free survival rates in the MSI group were 95.0, 92.0, and 80.0 per cent for patients with stage I, II, and III tumours, compared with 88.0, 88.0, and 65.0 per cent in the MSS group (P = 0.753, P = 0.487, and P = 0.105 respectively). Conclusion: Patients with early-onset colonic cancer have a high risk of MSI and defined genetic conditions. Those with MSI tumours have more adverse pathology (budding, KRAS/BRAF mutations, and nodal metastases) than older patients with MSI cancers.
AB - Background: The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. Methods: Anonymized data from an international collaboration were analysed. Criteria for inclusion were patients younger than 50 years diagnosed with stage I-III colonic cancer that was surgically resected. Clinicopathological features, microsatellite status, and disease-specific outcomes were evaluated. Results: A total of 650 patients fulfilled the criteria for inclusion. Microsatellite instability (MSI) was identified in 170 (26.2 per cent), whereas 480 had microsatellite-stable (MSS) tumours (relative risk of MSI 2.5 compared with older patients). MSI was associated with a family history of colorectal cancer and lesions in the proximal colon. The proportions with pathological node-positive disease (45.9 versus 45.6 per cent; P = 1.000) and tumour budding (20.3 versus 20.5 per cent; P = 1.000) were similar in the two groups. Patients with MSI tumours were more likely to have BRAF (22.5 versus 6.9 per cent; P < 0.001) and KRAS (40.0 versus 24.2 per cent; P = 0.006) mutations, and a hereditary cancer syndrome (30.0 versus 5.0 per cent; P < 0.001; relative risk 6). Five-year disease-free survival rates in the MSI group were 95.0, 92.0, and 80.0 per cent for patients with stage I, II, and III tumours, compared with 88.0, 88.0, and 65.0 per cent in the MSS group (P = 0.753, P = 0.487, and P = 0.105 respectively). Conclusion: Patients with early-onset colonic cancer have a high risk of MSI and defined genetic conditions. Those with MSI tumours have more adverse pathology (budding, KRAS/BRAF mutations, and nodal metastases) than older patients with MSI cancers.
UR - http://www.scopus.com/inward/record.url?scp=85132452889&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/bjs/znac108
DO - https://doi.org/10.1093/bjs/znac108
M3 - Article
C2 - 35522613
SN - 0007-1323
VL - 109
SP - 632
EP - 636
JO - British Journal of Surgery
JF - British Journal of Surgery
IS - 7
ER -