TY - JOUR
T1 - Impaired health-related quality of life in meningioma patients - A systematic review
AU - Zamanipoor Najafabadi, Amir H.
AU - Peeters, Marthe C.M.
AU - Dirven, Linda
AU - Lobatto, Daniel J.
AU - Groen, Justus L.
AU - Broekman, Marieke L.D.
AU - Peerdeman, Saskia M.
AU - Peul, Wilo C.
AU - Taphoorn, Martin J.B.
AU - Van Furth, Wouter R.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - While surgical and radiotherapeutic improvements increased life expectancy of meningioma patients, little is known about these patients' health-related quality of life (HRQoL). Therefore, the objectives of this systematic review were to assess HRQoL in meningioma patients, the methodological quality of the used questionnaires (COSMIN criteria), and the reporting level of patient-reported outcomes (PROs) in the included studies (International Society of Quality of Life Research criteria). Nineteen articles met our inclusion criteria. HRQoL was measured with 13 different questionnaires, 3 validated in meningioma patients. According to our predefined cutoff, HRQoL data were reported sufficiently in 5 out of 19 studies. Both findings hamper interpretation of the PRO results. In general, meningioma patients reported clinically worse HRQoL than healthy controls. Although meningioma patients had better HRQoL than glioma patients, this difference was not clinically relevant. Radiotherapy seemed to improve some domains of HRQoL in the short term, while HRQoL decreased to pre-radiotherapy levels in the long term. Tumor resection increased HRQoL, but long-term follow-up showed persistent reduced HRQoL compared with healthy controls. These results suggest an impaired HRQoL in meningioma patients, even years after anti-tumor treatment. Results of this systematic review warrant high quality prospective studies, better instruments to assess HRQoL, and improved level of reporting for this group of patients.
AB - While surgical and radiotherapeutic improvements increased life expectancy of meningioma patients, little is known about these patients' health-related quality of life (HRQoL). Therefore, the objectives of this systematic review were to assess HRQoL in meningioma patients, the methodological quality of the used questionnaires (COSMIN criteria), and the reporting level of patient-reported outcomes (PROs) in the included studies (International Society of Quality of Life Research criteria). Nineteen articles met our inclusion criteria. HRQoL was measured with 13 different questionnaires, 3 validated in meningioma patients. According to our predefined cutoff, HRQoL data were reported sufficiently in 5 out of 19 studies. Both findings hamper interpretation of the PRO results. In general, meningioma patients reported clinically worse HRQoL than healthy controls. Although meningioma patients had better HRQoL than glioma patients, this difference was not clinically relevant. Radiotherapy seemed to improve some domains of HRQoL in the short term, while HRQoL decreased to pre-radiotherapy levels in the long term. Tumor resection increased HRQoL, but long-term follow-up showed persistent reduced HRQoL compared with healthy controls. These results suggest an impaired HRQoL in meningioma patients, even years after anti-tumor treatment. Results of this systematic review warrant high quality prospective studies, better instruments to assess HRQoL, and improved level of reporting for this group of patients.
KW - health-related quality of life
KW - meningioma
KW - patient-reported outcome
KW - questionnaires
KW - reporting level
UR - http://www.scopus.com/inward/record.url?scp=85021785087&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/neuonc/now250
DO - https://doi.org/10.1093/neuonc/now250
M3 - Review article
C2 - 28039363
SN - 1522-8517
VL - 19
SP - 897
EP - 907
JO - Neuro-oncology
JF - Neuro-oncology
IS - 7
ER -