TY - JOUR
T1 - Impairment in complex activities of daily living is related to neurodegeneration in Alzheimer's disease-specific regions
AU - Jutten, Roos J
AU - Dicks, Ellen
AU - Vermaat, Lieke
AU - Barkhof, Frederik
AU - Scheltens, Philip
AU - Tijms, Betty M
AU - Sikkes, Sietske A M
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Impairment in instrumental activities of daily living (IADL) is an early clinical feature of Alzheimer's disease (AD). The neurobiology underlying IADL disruptions is still unclear. We aimed to investigate the relationship between IADL functioning and cortical atrophy across the AD spectrum. We selected 162 memory-clinic subjects with subjective cognitive decline (n = 49), mild cognitive impairment (n = 26) or AD dementia (n = 87), and an available structural MRI acquired at 3.0 Tesla and Amsterdam IADL Questionnaire (A-IADL-Q) assessment. We used linear regression correcting for age, sex, education, vascular injuries, and total intracranial volume to investigate the association between gray matter volume and A-IADL-Q score, and voxel-based morphometry to investigate whether any associations were specific for distinct regions. Less gray matter volume was associated with lower A-IADL-Q scores (β = 0.346, 95% CI = [0.185-0.507], p < 0.001), specifically in cortical regions covering the medial temporal lobes, cingulate cortex, and precuneus (all p(familywise error-corrected) < 0.05). Results were similar when repeating the analyses in amyloid-positive subjects (n = 78). Our findings illustrate that the A-IADL-Q detects functional impairment related to AD-specific neurodegeneration.
AB - Impairment in instrumental activities of daily living (IADL) is an early clinical feature of Alzheimer's disease (AD). The neurobiology underlying IADL disruptions is still unclear. We aimed to investigate the relationship between IADL functioning and cortical atrophy across the AD spectrum. We selected 162 memory-clinic subjects with subjective cognitive decline (n = 49), mild cognitive impairment (n = 26) or AD dementia (n = 87), and an available structural MRI acquired at 3.0 Tesla and Amsterdam IADL Questionnaire (A-IADL-Q) assessment. We used linear regression correcting for age, sex, education, vascular injuries, and total intracranial volume to investigate the association between gray matter volume and A-IADL-Q score, and voxel-based morphometry to investigate whether any associations were specific for distinct regions. Less gray matter volume was associated with lower A-IADL-Q scores (β = 0.346, 95% CI = [0.185-0.507], p < 0.001), specifically in cortical regions covering the medial temporal lobes, cingulate cortex, and precuneus (all p(familywise error-corrected) < 0.05). Results were similar when repeating the analyses in amyloid-positive subjects (n = 78). Our findings illustrate that the A-IADL-Q detects functional impairment related to AD-specific neurodegeneration.
KW - Alzheimer's disease
KW - Atrophy
KW - Dementia
KW - Instrumental activities of daily living
KW - Neurodegeneration
UR - http://www.scopus.com/inward/record.url?scp=85058394129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058394129&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neurobiolaging.2018.11.018
DO - https://doi.org/10.1016/j.neurobiolaging.2018.11.018
M3 - Article
C2 - 30557769
SN - 0197-4580
VL - 75
SP - 109
EP - 116
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -
