TY - JOUR
T1 - Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence
AU - Hamann, Jörg
AU - Kwakkenbos, Mark J.
AU - de Jong, Esther C.
AU - Heus, Henk
AU - Olsen, Anne S.
AU - van Lier, René A. W.
PY - 2003
Y1 - 2003
N2 - We here report on the identification of a novel human EGF-TM7 receptor, designated EMR4. Like most EGF-TM7 receptor genes, EMR4 is localized on the short arm of chromosome 19, in close proximity to EMR1. Remarkably, due to a one-nucleotide deletion in exon 8, translation of human EMR4 would result in a truncated 232-amino acid protein lacking the entire seven-span transmembrane region. This deletion is not present in nonhuman primates, including chimpanzees, suggesting that EMR4 became nonfunctional only after human speciation, about five million years ago. Thus, EMR4 surprisingly accounts for a genetic difference between humans and primates related to immunity
AB - We here report on the identification of a novel human EGF-TM7 receptor, designated EMR4. Like most EGF-TM7 receptor genes, EMR4 is localized on the short arm of chromosome 19, in close proximity to EMR1. Remarkably, due to a one-nucleotide deletion in exon 8, translation of human EMR4 would result in a truncated 232-amino acid protein lacking the entire seven-span transmembrane region. This deletion is not present in nonhuman primates, including chimpanzees, suggesting that EMR4 became nonfunctional only after human speciation, about five million years ago. Thus, EMR4 surprisingly accounts for a genetic difference between humans and primates related to immunity
U2 - https://doi.org/10.1002/eji.200323881
DO - https://doi.org/10.1002/eji.200323881
M3 - Article
C2 - 12731063
SN - 0014-2980
VL - 33
SP - 1365
EP - 1371
JO - European journal of immunology
JF - European journal of immunology
IS - 5
ER -