TY - JOUR
T1 - Induction and maintenance of CD8+ T cells specific for persistent viruses
AU - van Leeuwen, Ester M. M.
AU - ten Berge, Ineke J. M.
AU - van Lier, René A. W.
PY - 2007
Y1 - 2007
N2 - The development of immunological memory is a unique property of the adaptive immune system. Until recently most studies on the induction of virus-specific memory CD8(+) T cells have been performed in mice models of acute infection. Based on these studies, certain properties have been attributed to memory CD8(+) T cells concerning their responsiveness to antigenic stimulation and their ability to survive. However, many relevant human viruses are persistent and reach a latency stage in which
AB - The development of immunological memory is a unique property of the adaptive immune system. Until recently most studies on the induction of virus-specific memory CD8(+) T cells have been performed in mice models of acute infection. Based on these studies, certain properties have been attributed to memory CD8(+) T cells concerning their responsiveness to antigenic stimulation and their ability to survive. However, many relevant human viruses are persistent and reach a latency stage in which
U2 - https://doi.org/10.1007/978-0-387-34814-8_9
DO - https://doi.org/10.1007/978-0-387-34814-8_9
M3 - Article
C2 - 17191382
SN - 0065-2598
VL - 590
SP - 121
EP - 137
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -