Inflammation at the blood-brain barrier: The role of liver X receptors

N. M. de Wit; J. Vanmol; A. Kamermans; J. J.A. Hendriks; H. E. de Vries

doi:https://doi.org/10.1016/j.nbd.2016.09.015

Inflammation at the blood-brain barrier: The role of liver X receptors

N. M. de Wit, J. Vanmol, A. Kamermans, J. J.A. Hendriks, H. E. de Vries

Research output: Contribution to journal › Review article › Academic › peer-review

20 Citations (Scopus)

Abstract

The blood-brain barrier (BBB) is indispensable for the maintenance of brain homeostasis and proper neuronal functioning. Dysfunction of the BBB significantly contributes to the pathogenesis of neuroinflammatory and neurodegenerative diseases like stroke, multiple sclerosis (MS), and Alzheimer's disease (AD). The neuroinflammatory environment that characterizes these disorders propagates chronic impaired function of the BBB, processes that will be discussed in this review. Limiting dysfunction of the BBB may be an attractive target for treatment of neurological disorders. To date, no current treatments are directly targeting the function of the BBB. In this review, we will specifically discuss the potential protective role of nuclear liver X receptors (LXRs) as a promising therapeutic target to reverse or prevent BBB impairment in neurological diseases.

Original language	English
Pages (from-to)	57-65
Number of pages	9
Journal	Neurobiology of Disease
Volume	107
DOIs	https://doi.org/10.1016/j.nbd.2016.09.015
Publication status	Published - 1 Nov 2017

Keywords

Blood-brain barrier
Liver X receptor
Neurodegenerative disease
Neuroinflammation
Tight junction

Access to Document

https://doi.org/10.1016/j.nbd.2016.09.015

Cite this

@article{aa55cc4f254e4f8a95cf6981a130daa9,

title = "Inflammation at the blood-brain barrier: The role of liver X receptors",

abstract = "The blood-brain barrier (BBB) is indispensable for the maintenance of brain homeostasis and proper neuronal functioning. Dysfunction of the BBB significantly contributes to the pathogenesis of neuroinflammatory and neurodegenerative diseases like stroke, multiple sclerosis (MS), and Alzheimer's disease (AD). The neuroinflammatory environment that characterizes these disorders propagates chronic impaired function of the BBB, processes that will be discussed in this review. Limiting dysfunction of the BBB may be an attractive target for treatment of neurological disorders. To date, no current treatments are directly targeting the function of the BBB. In this review, we will specifically discuss the potential protective role of nuclear liver X receptors (LXRs) as a promising therapeutic target to reverse or prevent BBB impairment in neurological diseases.",

keywords = "Blood-brain barrier, Liver X receptor, Neurodegenerative disease, Neuroinflammation, Tight junction",

author = "{de Wit}, {N. M.} and J. Vanmol and A. Kamermans and Hendriks, {J. J.A.} and {de Vries}, {H. E.}",

year = "2017",

month = nov,

day = "1",

doi = "https://doi.org/10.1016/j.nbd.2016.09.015",

language = "English",

volume = "107",

pages = "57--65",

journal = "Neurobiology of Disease",

issn = "0969-9961",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Inflammation at the blood-brain barrier

T2 - The role of liver X receptors

AU - de Wit, N. M.

AU - Vanmol, J.

AU - Kamermans, A.

AU - Hendriks, J. J.A.

AU - de Vries, H. E.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - The blood-brain barrier (BBB) is indispensable for the maintenance of brain homeostasis and proper neuronal functioning. Dysfunction of the BBB significantly contributes to the pathogenesis of neuroinflammatory and neurodegenerative diseases like stroke, multiple sclerosis (MS), and Alzheimer's disease (AD). The neuroinflammatory environment that characterizes these disorders propagates chronic impaired function of the BBB, processes that will be discussed in this review. Limiting dysfunction of the BBB may be an attractive target for treatment of neurological disorders. To date, no current treatments are directly targeting the function of the BBB. In this review, we will specifically discuss the potential protective role of nuclear liver X receptors (LXRs) as a promising therapeutic target to reverse or prevent BBB impairment in neurological diseases.

AB - The blood-brain barrier (BBB) is indispensable for the maintenance of brain homeostasis and proper neuronal functioning. Dysfunction of the BBB significantly contributes to the pathogenesis of neuroinflammatory and neurodegenerative diseases like stroke, multiple sclerosis (MS), and Alzheimer's disease (AD). The neuroinflammatory environment that characterizes these disorders propagates chronic impaired function of the BBB, processes that will be discussed in this review. Limiting dysfunction of the BBB may be an attractive target for treatment of neurological disorders. To date, no current treatments are directly targeting the function of the BBB. In this review, we will specifically discuss the potential protective role of nuclear liver X receptors (LXRs) as a promising therapeutic target to reverse or prevent BBB impairment in neurological diseases.

KW - Blood-brain barrier

KW - Liver X receptor

KW - Neurodegenerative disease

KW - Neuroinflammation

KW - Tight junction

UR - http://www.scopus.com/inward/record.url?scp=84995680323&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.nbd.2016.09.015

DO - https://doi.org/10.1016/j.nbd.2016.09.015

M3 - Review article

C2 - 27659108

SN - 0969-9961

VL - 107

SP - 57

EP - 65

JO - Neurobiology of Disease

JF - Neurobiology of Disease

ER -

Inflammation at the blood-brain barrier: The role of liver X receptors

Abstract

Keywords

Access to Document

Other files and links

Cite this